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Preparation and application of pH-responsive drug delivery systems
Abstract
Microenvironment-responsive drug delivery systems (DDSs) can achieve targeted drug delivery, reduce drug side effects and improve drug efficacies. Among them, pH-responsive DDSs have gained popularity since the pH in the diseased tissues such as cancer, bacterial infection and inflammation differs from a physiological pH of 7.4 and this difference could be harnessed for DDSs to release encapsulated drugs specifically to these diseased tissues. A variety of synthetic approaches have been developed to prepare pH-sensitive DDSs, including introduction of a variety of pH-sensitive chemical bonds or protonated/deprotonated chemical groups. A myriad of nano DDSs have been explored to be pH-responsive, including liposomes, micelles, hydrogels, dendritic macromolecules and organic-inorganic hybrid nanoparticles, and micron level microspheres. The prodrugs from drug-loaded pH-sensitive nano DDSs have been applied in research on anticancer therapy and diagnosis of cancer, inflammation, antibacterial infection, and neurological diseases. We have systematically summarized synthesis strategies of pH-stimulating DDSs, illustrated commonly used and recently developed nanocarriers for these DDSs and covered their potential in different biomedical applications, which may spark new ideas for the development and application of pH-sensitive nano DDSs.
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“Cationic polymers like chitosan swell in pH media below pKb due to the protonation of cationic amine/imine group (Ding et al., 2022; Rehman et al., 2022).”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Ding et al., 2022
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Metadata
- Authors
- Ding, H., Tan, P., Fu, S., Tian, X., Zhang, H., Ma, X., Gu, Z., & Luo, K.
- Affiliations
- Sichuan University (CN)
- Amgen (United States) (US)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Ma, Xuelei
- Luo, Kui
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2022-08
- Volume
- 348
- Pages
- 206-238
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W4281865876
- Cited by
- 645
- References
- 340
- Citations by year
- 2026: 182 · 2025: 261 · 2024: 114 · 2023: 76 · 2022: 12
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (51873120, 52073193, 81621003, 82002692)
- Sichuan University
- Sichuan University West China Hospital (ZYJC21013)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- targeted drug delivery, prodrugs, liposomes, micelles, hydrogels, dendritic macromolecules, organic-inorganic hybrid nanoparticles, microspheres, cancer therapy, cancer diagnosis, inflammation, neurological disorders
- MeSH terms
- Drug Carriers, Humans, Hydrogen-Ion Concentration, Inflammation, Micelles, Neoplasms, Drug Delivery Systems, Nanoparticles, Tumor Microenvironment
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