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Cited by 465

The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.

Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products

Open access
Ibrahim, Mohamed, Ramadan, Eslam, Elsadek, Nehal E., Emam, Sherif E., Shimizu, Taro, Ando, Hidenori, Ishima, Yu, Elgarhy, Omar Helmy, Sarhan, Hatem A., Hussein, Amal K., Ishida, Tatsuhiro·2022·Journal of Controlled Release
DOI 10.1016/j.jconrel.2022.09.031
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Abstract

Polyethylene glycol (PEG) is a versatile polymer that is widely used as an additive in foods and cosmetics, and as a carrier in PEGylated therapeutics. Even though PEG is thought to be less immunogenic, or perhaps even non-immunogenic, with a variety of physicochemical properties, there is mounting evidence that PEG causes immunogenic responses when conjugated with other materials such as proteins and nanocarriers. Under these conditions, PEG with other materials can result in the production of anti-PEG antibodies after administration. The antibodies that are induced seem to have a deleterious impact on the therapeutic efficacy of subsequently administered PEGylated formulations. In addition, hypersensitivity to PEGylated formulations could be a significant barrier to the utility of PEGylated products. Several reports have linked the presence of anti-PEG antibodies to incidences of complement activation-related pseudoallergy (CARPA) following the administration of PEGylated formulations. The use of COVID-19 mRNA vaccines, which are composed mainly of PEGylated lipid nanoparticles (LNPs), has recently gained wide acceptance, although many cases of post-vaccination hypersensitivity have been documented. Therefore, our review focuses not only on the importance of PEGs and its great role in improving the therapeutic efficacy of various medications, but also on the hypersensitivity reactions attributed to the use of PEGylated products that include PEG-based mRNA COVID-19 vaccines.

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Metadata

Authors
Ibrahim, M., Ramadan, E., Elsadek, N. E., Emam, S. E., Shimizu, T., Ando, H., Ishima, Y., Elgarhy, O. H., Sarhan, H. A., Hussein, A. K., & Ishida, T.
Venue
Journal of Controlled Release
Publisher
Elsevier BV
Published
2022-11
Volume
351
Pages
215-230
ISSN
0168-3659 (ISSN-L)
DOI
10.1016/j.jconrel.2022.09.031
OpenAlex
W4296904320
Cited by
465
References
165
FWCI
19.11
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products. https://app.cochat.ai/papers/10.1016/j.jconrel.2022.09.031
The paper
Ibrahim, M., Ramadan, E., Elsadek, N. E., Emam, S. E., Shimizu, T., Ando, H., Ishima, Y., Elgarhy, O. H., Sarhan, H. A., Hussein, A. K., & Ishida, T. (2022). Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products. Journal of Controlled Release. https://doi.org/10.1016/j.jconrel.2022.09.031

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.