The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.
Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects
Open accessAbstract
Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an ongoing research area that started before these versatile nanoparticles were successfully used as COVID-19 vaccines. Currently, efforts are underway to harness this platform for oncology therapeutics, mainly focusing on cancer vaccines targeting multiple neoantigens or direct intratumoural injections of mRNA–LNPs encoding pro-inflammatory cytokines. In this Review, we describe the opportunities of using mRNA–LNPs in oncology applications and discuss the challenges for successfully translating the findings of preclinical studies of these nanoparticles into the clinic. We critically appraise the potential of various mRNA–LNP targeting and delivery strategies, considering physiological, technological and manufacturing challenges. We explore these approaches in the context of the potential clinical applications best suited to each approach and highlight the obstacles that currently need to be addressed to achieve these applications. Finally, we provide insights from preclinical and clinical studies that are leading to this powerful platform being considered the next frontier in oncology treatment. In oncology, mRNA–lipid nanoparticles (LNPs) have been used either to achieve intratumoural expression of immune-stimulating cytokine combinations or as cancer vaccines, and new strategies are in development to enable the selective delivery of payloads into cancer cells previously considered unreachable. The authors of this Review present various approaches for delivering mRNA–LNPs to tumours and discuss improvements that will improve the selective targeting of cancer cells with mRNA–LNPs.
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Cites
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Cited by
Exosome for mRNA delivery: Strategies and therapeutic applications
Iqbal, Z., Rehman, K., Mahmood, A., Shabbir, M., Liang, Y., Duan, L., & Zeng, H. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02634-x · Cited by 144
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Metadata
- Authors
- Kon, E., Ad-El, N., Hazan-Halevy, I., Stotsky-Oterin, L., & Peer, D.
- Venue
- Nature Reviews Clinical Oncology
- Published
- 2023-08-16
- Volume
- 20
- Issue
- 11
- Pages
- 739-754
- ISSN
- 1759-4774 (ISSN-L)
- 1759-4782
- OpenAlex
- W4385879053
- Cited by
- 371
- References
- 180
- FWCI
- 9.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kon, E., Ad-El, N., Hazan-Halevy, I., Stotsky-Oterin, L., & Peer, D. (2023). Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects. Nature Reviews Clinical Oncology. https://doi.org/10.1038/s41571-023-00811-9
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