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Cited by 37Animal Virus Infections StudiesViral Infections and Immunology ResearchVirology and Viral Diseases

Pathogenesis of Experimental Encephalomyocarditis: A Histopathological, Immunohistochemical and Virological Study in Mice

Psalla, D., Psychas, V., Spyrou, V., Billinis, C., Papaioannou, N., Vlemmas, I.·2006·Journal of Comparative Pathology
DOI 10.1016/j.jcpa.2006.04.003
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Abstract

Mice (n=20) aged 8 weeks were infected, either by oronasal inoculation or by contact, with one of two different myocardial strains of encephalomyocarditis virus (EMCV), namely, the Greek strain 424/90 and the Belgian strain B279/95. The animals were killed at 18-59 days post-infection (dpi), except for two mice that died at 6 and 32 dpi, and samples of brain, heart, pancreas, kidney, Peyer's patches, spleen, lung and thymus were processed for virological, histopathological and immunohistochemical examination. Apart from the two deaths, the experimental infection was inapparent, but virus was invariably recovered from faeces and several organs. The main histopathological lesions were focal interstitial pancreatitis, depletion of thymus and Peyer's patches, and interstitial pneumonia. Additionally, in the two mice that died, multifocal interstitial myocarditis was observed. EMCV antigen was detected in the cytoplasm of pancreatic acinar cells and in macrophages of the lung and the thymus. Antigen was also detected in the cytoplasm of cardiac muscle cells from three animals, including the two that died. The results support the role of mice, in addition to rats, as reservoir hosts in the epidemiology of EMCV infections on pig farms.

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  • EMCV infection can be asymptomatic, but in mice generally induces encephalitis, member paralysis, myocarditis or type 1 diabetes.

    “EMCV infection can be asymptomatic,90 but in mice generally induces encephalitis,115 member paralysis,78,116-118 myocarditis119 or type 1 diabetes.120”

    From The encephalomyocarditis virus (2012) · cites this paper as [115]

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Authors
Psalla, D., Psychas, V., Spyrou, V., Billinis, C., Papaioannou, N., & Vlemmas, I.
Affiliations
  • Aristotle University of Thessaloniki (GR)
  • Technological Educational Institute of Thessaly (GR)
  • University of Thessaly (GR)
Corresponding author
Vlemmas, I.
ORCID
Venue
Journal of Comparative Pathology
Publisher
Elsevier BV
Published
2006-08
Volume
135
Issue
2-3
Pages
142-145
ISSN
0021-9975 (ISSN-L)
DOI
10.1016/j.jcpa.2006.04.003
OpenAlex
W2006346149
Cited by
37
References
44
Citations by year
2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 3
FWCI
1.59
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Comparative Pathology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Thessaly Institutional Repository (University of Thessaly) (submittedVersion)
Funders
European Commission
Topics
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
encephalomyocarditis virus, experimental infection in mice, pathogenesis, myocarditis, pancreatitis, Peyer's patches, interstitial lung disease, pigs
MeSH terms
Animals, Antigens, Viral, Disease Reservoirs, Encephalomyocarditis virus, Heart, Lung, Mice, Inbred BALB C, Myocarditis, Myocardium, Pancreatitis, Peyer's Patches, Swine, Swine Diseases, Thymus Gland, Lung Diseases, Interstitial, Cardiovirus Infections, Mice

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