Microbial recognition by Toll-like receptors

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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A Toll-like receptor recognizes bacterial DNA

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Toll-Like Receptors

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

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Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

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Toll-like receptors: critical proteins linking innate and acquired immunity

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The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

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Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

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Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

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The Microbiota-Gut-Brain Axis

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Gut microbiome and health: mechanistic insights

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YERSINIA OUTER PROTEINS: Role in Modulation of Host Cell Signaling Responses and Pathogenesis

Viboud, G. I., & Bliska, J. B. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.030804.121320 · Cited by 600

Genomic Insights into Syntrophy: The Paradigm for Anaerobic Metabolic Cooperation

Sieber, J. R., McInerney, M. J., & Gunsalus, R. P. (2010) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090110-102844 · Cited by 541

The microbiome: a key regulator of stress and neuroinflammation

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Induction of Proinflammatory Responses in Macrophages by the Glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum: CELL SIGNALING RECEPTORS, GPI STRUCTURAL REQUIREMENT, AND REGULATION OF GPI ACTIVITY

Krishnegowda, G., Hajjar, A., Zhu, J., Douglass, E., Uematsu, S., Akira, S., Woods, A., & Gowda, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m413541200 · Cited by 36

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

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RAGE regulation and signaling in inflammation and beyond

Kierdorf, K., & Fritz, G. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1012519 · Cited by 451

Signaling pathways in obesity: mechanisms and therapeutic interventions

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Neutrophil apoptosis and the resolution of infection

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The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

Varnum, M. M., & Ikezu, T. (2012) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-012-0181-2 · Cited by 412

Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes

Nagy, I., Pivarcsi, A., Kis, K., Koreck, A., Bodai, L., McDowell, A., Seltmann, H., Patrick, S., Zouboulis, C. C., & Kemény, L. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2006.04.001 · Cited by 375

Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons

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The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway

Chen, C., Kao, C., & Liu, C.-M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092729 · Cited by 351

Distinct Strains of Propionibacterium acnes Induce Selective Human β-Defensin-2 and Interleukin-8 Expression in Human Keratinocytes Through Toll-Like Receptors

Nagy, I., Pivarcsi, A., Koreck, A., Széll, M., Urbán, E. Z., & Kemény, L. V. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23705.x · Cited by 336

Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors

Jo, E., Yang, C., Choi, C. H., & Harding, C. V. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.00914.x · Cited by 335

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20

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Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: Underlying mechanisms

Teeling, J. L., & Perry, V. H. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.031 · Cited by 259

Trigeminal Nociceptors Express TLR-4 and CD14: a Mechanism for Pain due to Infection

Wadachi, R., & Hargreaves, K. (2006) · Journal of Dental Research · doi:10.1177/154405910608500108 · Cited by 244

Antitumor Activity of the TLR-5 Ligand Flagellin in Mouse Models of Cancer

Sfondrini, L., Rossini, A., Besusso, D., Merlo, A. C., Tagliabue, E., Ménard, S., & Balsari, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.6624 · Cited by 194

Long-term activation of TLR3 by Poly(I:C) induces inflammation and impairs lung function in mice

Stowell, N. C., Seideman, J. H., Raymond, H. A., Smalley, K. A., Lamb, R. J., Egenolf, D., Bugelski, P. J., Murray, L. A., Marsters, P. A., Bunting, R. A., et al. (2009) · Respiratory Research · doi:10.1186/1465-9921-10-43 · Cited by 187

MicroRNAs as Molecular Switches in Macrophage Activation

Curtale, G., Rubino, M., & Locati, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00799 · Cited by 193

Pathogen Recognition and Activation of the Innate Immune Response in Zebrafish

van der Vaart, M., Spaink, H. P., & Meijer, A. H. (2012) · Advances in Hematology · doi:10.1155/2012/159807 · Cited by 184

Essential Role for Caspase-8 in Toll-like Receptors and NFκB Signaling

Lemmers, B., Salmena, L., Bidère, N., Su, H., Matysiak-Zablocki, E., Murakami, K., Ohashi, P. S., Jurisicova, A., Lenardo, M., Hakem, R., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m606721200 · Cited by 181

The expression and roles of Toll-like receptors in the biology of the human neutrophil

Parker, L. C., Whyte, M. K. B., Dower, S., & Sabroe, I. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1104636 · Cited by 175

Supernatant of Bifidobacterium breve induces dendritic cell maturation, activation, and survival through a Toll-like receptor 2 pathway

Hoarau, C., Lagaraine, C., Martin, L., Velge-Roussel, F., & Lebranchu, Y. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.10.043 · Cited by 171

Activation of Toll-Like Receptor (TLR)2, TLR4, and TLR9 in the Mammalian Cornea Induces MyD88-Dependent Corneal Inflammation

Johnson, A. C., Heinzel, F. P., Diaconu, E., Sun, Y., Hise, A. G., Golenbock, D. T., Lass, J. H., & Pearlman, E. M. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-1077 · Cited by 167

Immunohistochemical localization of Toll‐like receptors 1–10 in periodontitis

Beklen, A., Hukkanen, M., Rautemaa‐Richardson, R., & Konttinen, Y. T. (2008) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2008.00448.x · Cited by 165

Induction of Proinflammatory Responses in Macrophages by the Glycosylphosphatidylinositols of Plasmodium falciparum

Zhu, J., Gowda, K., & Gowda, D. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m413539200 · Cited by 166

Epstein-Barr Virus Induces MCP-1 Secretion by Human Monocytes via TLR2

Gaudreault, É., Fiola, S., Olivier, M., & Gosselin, J. (2007) · Journal of Virology · doi:10.1128/jvi.00403-07 · Cited by 170

1. Overview of the human immune response

Chaplin, D. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.09.034 · Cited by 169

Innate immunity mediated by epidermal keratinocytes promotes acquired immunity involving Langerhans cells and T cells in the skin

Sugita, K., Kabashima, K., Atarashi, K., Shimauchi, T., Kobayashi, M., & TOKURA, Y. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03258.x · Cited by 152

TLR SIGNALING PATHWAY IN PATIENTS WITH SEPSIS

Salomão, R., Martins, P. S., Brunialti, M. K. C., Fernandes, M. D. L., Martos, L., Mendes, M. E., Gomes, N. E., & Rigato, O. (2008) · Shock · doi:10.1097/shk.0b013e318181af2a · Cited by 148

Gut Microbiota: A Perspective for Psychiatrists

Rea, K., Dinan, T. G., & Cryan, J. F. (2019) · Neuropsychobiology · doi:10.1159/000504495 · Cited by 146

TLR9 Is Required for the Gut-Associated Lymphoid Tissue Response following Oral Infection of Toxoplasma gondii

Minns, L. A., Menard, L. C., Foureau, D., Darche, S., Ronet, C., Mielcarz, D. W., Buzoni–Gatel, D., & Kasper, L. H. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.12.7589 · Cited by 144

Anti-inflammatory effects of resveratrol occur via inhibition of lipopolysaccharide-induced NF-κB activation in Caco-2 and SW480 human colon cancer cells

Panaro, M. A., Carofiglio, V. E., Acquafredda, A., Cavallo, P., & Cianciulli, A. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511007227 · Cited by 139

MyD88 and TLR2, but not TLR4, are required for host defense against Cryptococcus neoformans

Biondo, C., Midiri, A., Messina, L., Tomasello, F. F., Garufi, G., Catania, M. R., Bombaci, M., Beninati, C., Teti, G., & Mancuso, G. (2005) · European Journal of Immunology · doi:10.1002/eji.200425799 · Cited by 139

Dendritic cell immunoreceptors: C-type lectin receptors for pattern-recognition and signaling on antigen-presenting cells

Kanazawa, N. (2007) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2006.09.001 · Cited by 141

Functional analysis of a zebrafishmyd88mutant identifies key transcriptional components of the innate immune system

van der Vaart, M., van Soest, J. J., Spaink, H. P., & Meijer, A. H. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.010843 · Cited by 134

Nontypeable Haemophilus influenzae Initiates Formation of Neutrophil Extracellular Traps

Juneau, R. A., Pang, B., Weimer, K. E. D., Armbruster, C. E., & Swords, W. E. (2010) · Infection and Immunity · doi:10.1128/iai.00660-10 · Cited by 141

Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens

Cecil, J. D., O’brien-simpson, N. M., Lenzo, J. C., Holden, J. A., Chen, Y.-Y., Singleton, W., Gause, K. T., Yan, Y., Caruso, F., & Reynolds, E. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151967 · Cited by 129

Toll-like Receptors in Tumor Immunotherapy

Paulos, C. M., Kaiser, A., Wrzesinski, C., Hinrichs, C. S., Cassard, L., Boni, A., Muranski, P. J., Sanchez-Perez, L. A., Palmer, D. C., Yu, Z., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1378 · Cited by 124

Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation

Paciello, I., Silipo, A., Fazio, L. L., Curcurù, L., Zumsteg, A. B., Noël, G., Ciancarella, V., Sturiale, L., Molinaro, A., & Bernardini, M. L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303641110 · Cited by 123

Interferons (IFNs) are key cytokines in both innate and adaptive antiviral immune responses—and viruses counteract IFN action

Bonjardim, C. A. (2005) · Microbes and Infection · doi:10.1016/j.micinf.2005.02.001 · Cited by 123

Transcriptional Activation of Alpha/Beta Interferon Genes: Interference by Nonsegmented Negative-Strand RNA Viruses

Conzelmann, K. (2005) · Journal of Virology · doi:10.1128/jvi.79.9.5241-5248.2005 · Cited by 117

Toll-like receptor 9 (TLR9) is present in murine liver sinusoidal endothelial cells (LSECs) and mediates the effect of CpG-oligonucleotides

Martin‐Armas, M., Simón-Santamaría, J., Pettersen, I., Moens, U. L., Smedsrød, B. H., & Sveinbjørnsson, B. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.09.020 · Cited by 108

HIV Infection and Compromised Mucosal Immunity: Oral Manifestations and Systemic Inflammation

Heron, S., & Elahi, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00241 · Cited by 104

Toll-Like Receptor-2 Mediates Diet and/or Pathogen Associated Atherosclerosis: Proteomic Findings

Madan, M., & Amar, S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003204 · Cited by 95

Gingival epithelial cells heterozygous for Toll-like receptor 4 polymorphisms Asp299Gly and Thr399Ile are hypo-responsive to Porphyromonas gingivalis

Kinane, D. F., Shiba, H., Stathopoulou, P. G., Zhao, H., Lappin, D. F., Singh, A. V., Eskan, M. A., Beckers, S., Waigel, S. J., Alpert, B., et al. (2006) · Genes and Immunity · doi:10.1038/sj.gene.6364282 · Cited by 96

Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling

Shinohara, H., Inoue, A., Toyama‐Sorimachi, N., Nagai, Y., Yasuda, T., Suzuki, H., Horai, R., Iwakura, Y., Yamamoto, T. S., Karasuyama, H., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041817 · Cited by 92

Toll-like receptor 4 activates NF-κB and MAP kinase pathways to regulate expression of proinflammatory COX-2 in renal medullary collecting duct cells

Küper, C., Beck, F.-X., & Neuhofer, W. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00590.2010 · Cited by 92

The Radioprotective 105/MD-1 Complex Links TLR2 and TLR4/MD-2 in Antibody Response to Microbial Membranes

Nagai, Y., Kobayashi, T., Motoi, Y., Ishiguro, K., Akashi, S., Saitoh, S.-I., Kusumoto, Y., Kaisho, T., Akira, S., Matsumoto, M., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7043 · Cited by 92

Positive modulators of the α7 nicotinic receptor against neuroinflammation and cognitive impairment in Alzheimer's disease

Echeverría, V., Iarkov, A., & Aliev, G. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.002 · Cited by 95

[The role of Toll-like receptors (TLR) in innate and adaptive immune responses and their function in immune response regulation].

Majewska, M., & Szczepanik, M. (2006) · PubMed · Cited by 91

Evaluation of β-(1→3, 1→6)-glucans and High-M alginate used as immunostimulatory dietary supplement during first feeding and weaning of Atlantic cod (Gadus morhua L.)

Skjermo, J., Størseth, T. R., Hansen, K., Handå, A., & Øie, G. (2006) · Aquaculture · doi:10.1016/j.aquaculture.2006.07.035 · Cited by 90

The microbiota-gut-brain axis: Focus on the fundamental communication pathways

Bistoletti, M., Bosi, A., Banfi, D., Giaroni, C., & Baj, A. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.08.012 · Cited by 91

Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis

Martins, P. S., Brunialti, M. K. C., Martos, L., Machado, F. R., de Assunção, M. S. C., Blecher, S., & Salomão, R. (2008) · Critical Care · doi:10.1186/cc6801 · Cited by 88

Role of MyD88 and TLR9 in the Innate Immune Response Elicited by Serotype 5 Adenoviral Vectors

Yamaguchi, T., Kawabata, K., Koizumi, N., Sakurai, F., Kaneda‐Nakashima, K., Sakurai, H., Sasaki, T., Okada, N., Yamanishi, K., & Mizuguchi, H. (2007) · Human Gene Therapy · doi:10.1089/hum.2007.016 · Cited by 87

Distinct toll-like receptor expression in monocytes and T cells in chronic HCV infection

Dolganiuc, A. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i8.1198 · Cited by 88

The Molecular Basis and Clinical Consequences of Chronic Inflammation in Prostatic Diseases: Prostatitis, Benign Prostatic Hyperplasia, and Prostate Cancer

Oseni, S. O., Naar, C., Pavlović, M. D., Asghar, W., Hartmann, J. X., Fields, G. B., Esiobu, N., & Kumi-Diaka, J. K. (2023) · Cancers · doi:10.3390/cancers15123110 · Cited by 100

Expression and functionality of Toll‐like receptor 3 in the megakaryocytic lineage

D’Atri, L. P., Etulain, J., Rivadeneyra, L., Lapponi, M. J., Centurion, M., Cheng, K., Yin, H. H., & Schattner, M. A. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12842 · Cited by 80

Replacement of fishmeal by spirulina Arthrospira platensis affects growth, immune related-gene expression in gibel carp (Carassius auratus gibelio var. CAS III), and its challenge against Aeromonas hydrophila infection

Cao, S., Zhang, P., Zou, T., Fei, S., Han, D. H., Jin, J., Liu, H., Yang, Y., Zhu, X., & Xie, S. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.05.022 · Cited by 82

Potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte-derived dendritic cells

Latvala, S., Pietilä, T. E., Veckman, V., Kekkonen, R. A., Tynkkynen, S., Korpela, R., & Julkunen, I. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.5570 · Cited by 79

Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs

Hasan, U. A., Caux, C., Perrot, I., Doffin, A., Ménétrier‐Caux, C., Trinchieri, G., Tommasino, M., & Vlach, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700664104 · Cited by 78

High Basal Levels of Functional Toll-Like Receptor 3 (TLR3) and Noncanonical Wnt5a Are Expressed in Papillary Thyroid Cancer and Are Coordinately Decreased by Phenylmethimazole Together with Cell Proliferation and Migration

McCall, K. D., Harii, N., Lewis, C. J., Malgor, R., Kim, W. B., Saji, M., Kohn, A. D., Moon, R. T., & Kohn, L. D. (2007) · Endocrinology · doi:10.1210/en.2007-0459 · Cited by 76

2. Update on primary immunodeficiency diseases

Bonilla, F. A., & Geha, R. S. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.09.051 · Cited by 75

Macrophage-Elicited Osteoclastogenesis in Response to Bacterial Stimulation Requires Toll-Like Receptor 2-Dependent Tumor Necrosis Factor-Alpha Production

Ukai, T., Yumoto, H., Gibson, F., & Genco, C. (2007) · Infection and Immunity · doi:10.1128/iai.01241-07 · Cited by 77

Recognition of fungal RNA by TLR 7 has a nonredundant role in host defense against experimental candidiasis

Biondo, C., Malara, A., Costa, A., Signorino, G., Cardile, F., Midiri, A., Galbo, R., Papasergi, S., Domina, M., Pugliese, M., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201242532 · Cited by 61

Effect of toll‐like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma

Mohamed, F. E. Z. A., Al-Jehani, R. M., Minogue, S., Andreola, F., Winstanley, A. M., Damink, S. W. M. O., Habtesion, A., Malagó, M., Davies, N. A., Luong, T. V., et al. (2014) · Liver International · doi:10.1111/liv.12626 · Cited by 70

Involvement of Toll-Like Receptors 2 and 4 in the Innate Immune Response to Treponema denticola and Its Outer Sheath Components

Nussbaum, G., Ben-Adi, S., Genzler, T., Sela, M., & Rosen, G. (2009) · Infection and Immunity · doi:10.1128/iai.00488-09 · Cited by 70

Cross Talk between MyD88 and Focal Adhesion Kinase Pathways

Zeisel, M. B., Druet, V. A., Sibilia, J., Klein, J.-P., Quesniaux, V. F. J., & Wachsmann, D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7393 · Cited by 69

Unraveling the Complexities of Toll-like Receptors: From Molecular Mechanisms to Clinical Applications

Chen, Y.-H., Wu, K., & Wu, H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25095037 · Cited by 77

Up-regulated cathepsin C induces macrophage M1 polarization through FAK-triggered p38 MAPK/NF-κB pathway

Alam, S., Liu, Q., Liu, S., Liu, Y., Zhang, Y., Yang, X., Liu, G., Fan, K., & Ma, J. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.06.017 · Cited by 66

Measles virus–dendritic cell interaction via SLAM inhibits innate immunity: Selective signaling through TLR4 but not other TLRs mediates suppression of IL-12 synthesis

Hahm, B., Cho, J.-H., & Oldstone, M. B. A. (2006) · Virology · doi:10.1016/j.virol.2006.10.004 · Cited by 65

Lipopeptides for Vaccine Development

Hamley, I. W. (2021) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.1c00258 · Cited by 62

Clinical and Pathological Implications of Concurrent Autoimmune Thyroid Disorders and Papillary Thyroid Cancer

Cunha, L. L., Ferreira, R. C. U., Marcello, M. A., Vassallo, J., & Ward, L. S. (2011) · Journal of Thyroid Research · doi:10.4061/2011/387062 · Cited by 62

NF-κB Activation in Lymphoid Malignancies: Genetics, Signaling, and Targeted Therapy

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TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells

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