Microbial recognition by Toll-like receptors

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631

A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 1×

Toll-Like Receptors

Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129

Toll-like receptors: critical proteins linking innate and acquired immunity

Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,224

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80119-3 · Cited by 3,680

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3749 · Cited by 3,374

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,286

IKKε and TBK1 are essential components of the IRF3 signaling pathway

Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., & Akira, S. (2002) · Nature Immunology · doi:10.1038/ni758 · Cited by 2,580

Unresponsiveness of MyD88-deficient mice to endotoxin.

Kawai, T., Adachi, O., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80086-2 · Cited by 2,367

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

Ozinsky, A., Underhill, D. M., Fontenot, J. D., Hajjar, A. M., Smith, K. D., Wilson, C. B., Schroeder, L. A., & Aderem, A. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250476497 · Cited by 2,086

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

Kurt-Jones, E., Popova, L., Kwinn, L. A., Haynes, L., Jones, L. P., Tripp, R., Walsh, E., Freeman, M., Golenbock, D., Anderson, L., et al. (2000) · Nature Immunology · doi:10.1038/80833 · Cited by 1,842

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

Schwandner, R., Dziarski, R., Wesche, H., Rothe, M., & Kirschning, C. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17406 · Cited by 1,704

Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

Sharma, S., tenOever, B. R., Grandvaux, N., Zhou, G., Lin, R., & Hiscott, J. B. (2003) · Science · doi:10.1126/science.1081315 · Cited by 1,685

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

Ohashi, K., Burkart, V., Flohé, S. B., & Kolb, H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.558 · Cited by 1,607

Novel Signal Transduction Pathway Utilized by Extracellular HSP70

Asea, A., Rehli, M., Kabingu, E., Boch, J. A., Baré, O., Auron, P. E., Stevenson, M. A., & Calderwood, S. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200497200 · Cited by 1,510

Innate immune sensing and its roots: the story of endotoxin

Beutler, B., & Rietschel, E. (2003) · Nature reviews. Immunology · doi:10.1038/nri1004 · Cited by 1,392

Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

Termeer, C., Benedix, F., Sleeman, J., Fieber, C., Voith, U., Ahrens, T., Miyake, K., Freudenberg, M., Galanos, C., & Simon, J. C. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20001858 · Cited by 1,378

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

Underhill, D. M., Ozinsky, A., Hajjar, A. M., Stevens, A. M., Wilson, C. B., Bassetti, M., & Aderem, A. A. (1999) · Nature · doi:10.1038/44605 · Cited by 1,370

Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins

Takeuchi, O., Sato, S., Horiuchi, T., Hoshino, K., Takeda, K., Dong, Z., Modlin, R. L., & Akira, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.10 · Cited by 1,360

IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling

Kobayashi, K. S., Hernandez, L. D., Galán, J. E., Janeway, C. A., Medzhitov, R. M., & Flavell, R. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00827-9 · Cited by 1,310

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

von Bernuth, H., Pïcard, C., Jin, Z., Sranujit, R. P., Xiao, H. Q., Ku, C., Chrabieh, M., Ben‐Mustapha, I., Ghandil, P., Çamcıoğlu, Y., et al. (2008) · Science · doi:10.1126/science.1158298 · Cited by 1,287

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingPreprint

Lomaga, M. A., Yeh, W., Sarosi, I., Duncan, G. S., Furlonger, C. L., Ho, A. P., Morony, S., Capparelli, C., Van, G. Y., Kaufman, S., et al. (1999) · Genes & Development · doi:10.1101/gad.13.8.1015 · Cited by 1,265

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Fitzgerald, K. A., Pålsson‐McDermott, E. M., Bowie, A., Jefferies, C. A., Mansell, A. S., Brady, G., Brint, E. K., Dunne, A., Gray, P., Harte, M. T., et al. (2001) · Nature · doi:10.1038/35092578 · Cited by 1,258

Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

Yamamoto, M., Sato, S., Mori, K., Hoshino, K., Takeuchi, O., Takeda, K., & Akira, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.12.6668 · Cited by 1,246

Discrimination of bacterial lipoproteins by Toll-like receptor 6

Takeuchi, O., Kawai, T., Mühlradt, P. F., Morr, M., Radolf, J. D., Zychlinsky, A., Takeda, K., & Akira, S. (2001) · International Immunology · doi:10.1093/intimm/13.7.933 · Cited by 1,233

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

Hoebe, K. H. N., Du, X., Georgel, P., Janssen, E. M., Tabeta, K., Kim, S. O., Goode, J., Lin, P., Mann, N., Mudd, S., et al. (2003) · Nature · doi:10.1038/nature01889 · Cited by 1,232

The Extra Domain A of Fibronectin Activates Toll-like Receptor 4

Okamura, Y., Watari, M., Jerud, E. S., Young, D. W., Ishizaka, S. T., Rose, J., Chow, J. C., & Strauss, J. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100099200 · Cited by 1,217

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T., & Seya, T. (2003) · Nature Immunology · doi:10.1038/ni886 · Cited by 1,217

Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells

Lund, J. M., Sato, A., Akira, S., Medzhitov, R. M., & Iwasaki, A. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030162 · Cited by 1,197

Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible to Staphylococcus aureus Infection1

Takeuchi, O., Hoshino, K., & Akira, S. (2000) · Journal of Immunology · doi:10.4049/jimmunol.165.10.5392 · Cited by 1,156

Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes

Kawai, T., Takeuchi, O., Fujita, T., Inoue, J., Mühlradt, P. F., Sato, S., Hoshino, K., & Akira, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.10.5887 · Cited by 1,115

TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

Yamamoto, M., Sato, S., Hemmi, H., Uematsu, S., Hoshino, K., Kaisho, T., Takeuchi, O., Takeda, K., & Akira, S. (2003) · Nature Immunology · doi:10.1038/ni986 · Cited by 1,052

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

Yamamoto, M., Sato, S., Hemmi, H., Sanjo, H., Uematsu, S., Kaisho, T., Hoshino, K., Takeuchi, O., Kobayashi, M., Fujita, T., et al. (2002) · Nature · doi:10.1038/nature01182 · Cited by 1,009

TIRAP: an adapter molecule in the Toll signaling pathway

Horng, T., Barton, G. M., & Medzhitov, R. M. (2001) · Nature Immunology · doi:10.1038/ni0901-835 · Cited by 970

HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway

Vabulas, R. M., Ahmad‐Nejad, P., Ghose, S., Kirschning, C. J., Issels, R. D., & Wagner, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111204200 · Cited by 956

Fibrinogen Stimulates Macrophage Chemokine Secretion Through Toll-Like Receptor 4

Smiley, S. T., King, J. A., & Hancock, W. W. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.5.2887 · Cited by 946

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

Suzuki, N., Suzuki, S., Duncan, G. S., Millar, D. G., Wada, T., Mirtsos, C., Takada, H., Wakeham, A. C., Itié, A., Li, S., et al. (2002) · Nature · doi:10.1038/nature736 · Cited by 861

IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program

Doyle, S. E., Vaidya, S. A., O’Connell, R. M., Dadgostar, H., Dempsey, P. W., Wu, T., Rao, G., Sun, R., Haberland, M. E., Modlin, R. L., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00390-4 · Cited by 847

Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF‐3 and CBP/p300

Yoneyama, M., Suhara, W., Fukuhara, Y., Fukuda, M., Nishida, E., & Fujita, T. (1998) · The EMBO Journal · doi:10.1093/emboj/17.4.1087 · Cited by 841

Pyogenic Bacterial Infections in Humans with IRAK-4 Deficiency

Pïcard, C., Puel, A., Bonnet, M., Ku, C., Bustamante, J. C., Yang, K., Soudais, C., Boisson‐Dupuis, S., Feinberg, J. M., Fieschi, C., et al. (2003) · Science · doi:10.1126/science.1081902 · Cited by 828

Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages

Underhill, D. M., Ozinsky, A., Smith, K. D., & Aderem, A. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14459 · Cited by 827

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

Horng, T., Barton, G. M., Flavell, R. A., & Medzhitov, R. M. (2002) · Nature · doi:10.1038/nature01180 · Cited by 825

Endocytosed HSP60s Use Toll-like Receptor 2 (TLR2) and TLR4 to Activate the Toll/Interleukin-1 Receptor Signaling Pathway in Innate Immune Cells

Vabulas, R. M., Ahmad-Nejad, P., da Costa, C., Miethke, T., Kirschning, C. J., Häcker, H., & Wagner, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103217200 · Cited by 805

Human Toll-Like Receptors Mediate Cellular Activation by Mycobacterium tuberculosis

Means, T. K., Wang, S., Lien, E., Yoshimura, A., Golenbock, D. T., & Fenton, M. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.3920 · Cited by 804

TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages

Toshchakov, V. Y., Jones, B. W., Perera, P., Thomas, K., Cody, M. J., Zhang, S., Williams, B. R. G., Major, J. A., Hamilton, T. A., Fenton, M. J., et al. (2002) · Nature Immunology · doi:10.1038/ni774 · Cited by 802

IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase

Li, S., Strelow, A., Fontana, E. J., & Wesche, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082100399 · Cited by 714

Receptor-Mediated Monitoring of Tissue Well-Being Via Detection of Soluble Heparan Sulfate by Toll-Like Receptor 4

Johnson, G. B., Brunn, G. J., Kodaira, Y., & Platt, J. L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.10.5233 · Cited by 648

Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice

Naito, A., Azuma, S., Tanaka, S., Miyazaki, T., Takaki, S., Takatsu, K., Nakao, K., Nakamura, K., Katsuki, M., Yamamoto, T. S., et al. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00265.x · Cited by 626

Limb and Skin Abnormalities in Mice Lacking IKKα

Takeda, K., Takeuchi, O., Tsujimura, T., Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K., Terada, N., & Akira, S. (1999) · Science · doi:10.1126/science.284.5412.313 · Cited by 606

NF‐κB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK‐related kinase

Pomerantz, J. L., & Baltimore, D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.23.6694 · Cited by 599

Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite

Campos, M. A., de Almeida, I. C., Takeuchi, O., Akira, S., Valente, E. P., Procópio, D. O., Travassos, L. R., Smith, J. A., Golenbock, D. T., & Gazzinelli, R. T. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.416 · Cited by 587

Cutting Edge: Preferentially the R -Stereoisomer of the Mycoplasmal Lipopeptide Macrophage-Activating Lipopeptide-2 Activates Immune Cells Through a Toll-Like Receptor 2- and MyD88-Dependent Signaling Pathway

Takeuchi, O., Kaufmann, A. M., Grote, K., Kawai, T., Hoshino, K., Morr, M., Mühlradt, P. F., & Akira, S. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.554 · Cited by 569

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.

Rudolph, D., Yeh, W., Wakeham, A. C., Rudolph, B., Nallainathan, D., Potter, J., Elia, A., & Mak, T. W. (2000) · PubMed Central · Cited by 518

Cutting Edge: MyD88 Is Required for Resistance to Toxoplasma gondii Infection and Regulates Parasite-Induced IL-12 Production by Dendritic Cells

Scanga, C. A., Aliberti, J., Jankovic, D. L., Tilloy, F., Bennouna, S., Denkers, E., Medzhitov, R. M., & Sher, A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.5997 · Cited by 500

The Toll–IL-1 receptor adaptor family grows to five members

O'Neill, L. A. J., Fitzgerald, K. A., & Bowie, A. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00115-7 · Cited by 497

Involvement of Toll-Like Receptor 4 in Innate Immunity to Respiratory Syncytial Virus

Haynes, L. M., Moore, D. D., Kurt‐Jones, E. A., Finberg, R. W., Anderson, L. J., & Tripp, R. A. (2001) · Journal of Virology · doi:10.1128/jvi.75.22.10730-10737.2001 · Cited by 496

Murine retroviruses activate B cells via interaction with toll-like receptor 4

Rassa, J., Meyers, J., Zhang, Y., Kudaravalli, R., & Ross, S. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.042355399 · Cited by 493

Severe liver degeneration and lack of NF-κ B activation in NEMO/IKKγ-deficient mice

Rudolph, D., Yeh, W.-C., Wakeham, A., Rudolph, B., Nallainathan, D., Potter, J., Elia, A. J., & Mak, T. W. (2000) · Genes & Development · doi:10.1101/gad.14.7.854 · Cited by 479

A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling

Bowie, A., Kiss‐Toth, E., Symons, J. A., Smith, G. L., Dower, S., & O'Neill, L. A. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160027697 · Cited by 466

Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin

Hajjar, A. M., O’Mahony, D. S., Ozinsky, A., Underhill, D. M., Aderem, A. A., Klebanoff, S. J., & Wilson, C. B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.15 · Cited by 465

Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling

Matsumoto, M., Kikkawa, S., Kohase, M., Miyake, K., & Seya, T. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00380-7 · Cited by 459

The CD14 Ligands Lipoarabinomannan and Lipopolysaccharide Differ in Their Requirement for Toll-Like Receptors

Means, T. K., Lien, E., Yoshimura, A., Wang, S., Golenbock, D. T., & Fenton, M. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6748 · Cited by 431

Endotoxin Contamination in Recombinant Human Heat Shock Protein 70 (Hsp70) Preparation Is Responsible for the Induction of Tumor Necrosis Factor α Release by Murine Macrophages

Gao, B., & Tsan, M.-F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208742200 · Cited by 396

JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection

Chu, W., Ostertag, D. G., Li, Z.-W., Chang, L., Chen, Y., Hu, Y., Williams, B. R. G., Perrault, J., & Karin, M. (1999) · Immunity · doi:10.1016/s1074-7613(00)80146-6 · Cited by 389

The Poxvirus Protein A52R Targets Toll-like Receptor Signaling Complexes to Suppress Host Defense

Harte, M. T., Haga, I. R., Maloney, G., Gray, P., Reading, P. C., Bartlett, N. W., Smith, G. L., Bowie, A., & O'Neill, L. A. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021652 · Cited by 372

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IκB kinases

Shimada, T., Kawai, T., Takeda, K., Matsumoto, M., Inoue, J., Tatsumi, Y., Kanamaru, A., & Akira, S. (1999) · International Immunology · doi:10.1093/intimm/11.8.1357 · Cited by 369

GENETIC CONTROL OF RESPONSES TO BACTERIAL LIPOPOLYSACCHARIDES IN MICE

Watson, J. D., & Riblet, R. J. (1974) · The Journal of Experimental Medicine · doi:10.1084/jem.140.5.1147 · Cited by 353

Interferon Regulatory Factor 3 and CREB-Binding Protein/p300 Are Subunits of Double-Stranded RNA-Activated Transcription Factor DRAF1

Weaver, B. K., Kumar, K. P., & Reich, N. C. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.3.1359 · Cited by 348

The Roles of Toll-Like Receptor 9, MyD88, and DNA-Dependent Protein Kinase Catalytic Subunit in the Effects of Two Distinct CpG DNAs on Dendritic Cell Subsets

Hemmi, H., Kaisho, T., Takeda, K., & Akira, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3059 · Cited by 344

IKKε Is Part of a Novel PMA-Inducible IκB Kinase Complex

Peters, R., Liao, S.-M., & Maniatis, T. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80445-1 · Cited by 335

Cutting Edge: Immune Stimulation by Neisserial Porins Is Toll-Like Receptor 2 and MyD88 Dependent

Massari, P., Henneke, P., Ho, Y., Latz, E., Golenbock, D. T., & Wetzler, L. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.4.1533 · Cited by 292

Differential involvement of IFN- in Toll-like receptor-stimulated dendritic cell activation

Hoshino, K., Kaisho, T., Iwabe, T., Takeuchi, O., & Akira, S. (2002) · International Immunology · doi:10.1093/intimm/dxf089 · Cited by 287

Induction of Cross-Tolerance by Lipopolysaccharide and Highly Purified Lipoteichoic Acid Via Different Toll-Like Receptors Independent of Paracrine Mediators

Lehner, M. D., Morath, S., Michelsen, K. S., Schumann, R. R., & Härtung, T. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.5161 · Cited by 284

Impaired Cytokine Signaling in Mice Lacking the IL-1 Receptor-Associated Kinase

Thomas, J. A., Allen, J. L., Tsen, M. F., Dubnicoff, T., Danao, J., Liao, X. C., Cao, Z., & Wasserman, S. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.2.978 · Cited by 280

IL-1 Receptor-Associated Kinase Modulates Host Responsiveness to Endotoxin

Swantek, J. L., Tsen, M. F., Cobb, M. H., & Thomas, J. A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.8.4301 · Cited by 279

Essential role of IRF-3 in lipopolysaccharide-induced interferon-β gene expression and endotoxin shock

Sakaguchi, S., Negishi, H., Asagiri, M., Nakajima, C., Mizutani, T., Takaoka, A., Honda, K., & Taniguchi, T. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01049-0 · Cited by 264

Cutting Edge: Administration of Anti-CD40 Ligand and Donor Bone Marrow Leads to Hemopoietic Chimerism and Donor-Specific Tolerance Without Cytoreductive Conditioning

Durham, M. M., Bingaman, A. W., Adams, A. B., Ha, J., Waitze, S. R., Pearson, T. C., & Larsen, C. P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.1 · Cited by 248

Toll-like Receptor-2 Mediates Treponema Glycolipid and Lipoteichoic Acid-induced NF-κB Translocation

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