The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor
Abstract
Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological effects by inducing the transcription of various AHR-responsive genes such as epidermal barrier proteins. The activation of AHR usually generates oxidative stress. However, AHR also mediates antioxidant signaling by a plethora of ligands via nuclear factor-erythroid 2-related factor-2. Both oxidative and antioxidant ligands upregulate the expression of the filaggrin gene. We review the role of AHR signaling in the gene regulation of epidermal barrier proteins.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Various herbal and antioxidant phytochemicals have been shown to activate AHR [16,17,19].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [17]
In the citing paper
“In addition to CYP1A1 induction, AHR is an essential transcription factor for human epidermal barrier proteins including FLG and LOR [17,28,29].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [17]
Citations
Cites
Functional role of AhR in the expression of toxic effects by TCDD
Mimura, J., & Fujii‐Kuriyama, Y. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00485-3 · Cited by 754
Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E., & Zhao, B. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr218 · Cited by 748
The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor
Nguyen, L. P., & Bradfield, C. A. (2007) · Chemical Research in Toxicology · doi:10.1021/tx7001965 · Cited by 718
Aryl hydrocarbon receptors: diversity and evolution
Hahn, M. E. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00070-4 · Cited by 642
Fritsche, E., Schäfer, C., Calles, C., Bernsmann, T., Bernshausen, T., Wurm, M., Hübenthal, U., Cline, J. E., Hajimiragha, H., Schroeder, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701764104 · Cited by 437
The cancer chemopreventive actions of phytochemicals derived from glucosinolates
Hayes, J. D., Kelleher, M., & Eggleston, I. M. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-2009-8 · Cited by 404
Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis
van den Bogaard, E. H., Bergboer, J. G. M., Vonk-Bergers, M., van Vlijmen-Willems, I. M. J. J., Hato, S. V., van der Valk, P. G. M., Schröder, J. M., Joosten, I., Zeeuwen, P. L. J. M., & Schalkwijk, J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65642 · Cited by 373
Lesions of Aryl-hydrocarbon Receptor–deficient Mice
Fernández‐Salguero, P. M., Ward, J. M., Sundberg, J. P., & Gonzalez, F. J. (1997) · Veterinary Pathology · doi:10.1177/030098589703400609 · Cited by 352
Kypriotou, M., Huber, M., & Hohl, D. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01472.x · Cited by 338
Quercetin regulates Th1/Th2 balance in a murine model of asthma
Park, H.-J., Lee, C., Jung, I. D., Lee, J. S., Jeong, Y.-I., Chang, J. H., Chun, S.-H., Kim, M., Choi, I., Ahn, S., et al. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.10.021 · Cited by 228
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–133 of 133
Esser, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041844 · Cited by 5
Kucharska, M., Kwiliński, K., Wawrzyńska, B., Cąkała, M., Kruszewski, A., Paduszyńska, N., Dąbrowska, A., Przybysz, P., & Szyszka, M. (2024) · Quality in Sport · doi:10.12775/qs.2024.19.54073 · Cited by 4
Ehsan, M. T., Rehman, A. U., Athar, F., Mustafa, B., Javed, H., Cheema, H. A., Ayyan, M., Shahid, A., Jafar, U., & Goldust, M. (2022) · Dermatologic Therapy · doi:10.1111/dth.15957 · Cited by 4
The role of the aromatic hydrocarbon receptor in the pathogenesis of atopic dermatitis
Gorodnichev, P. V. (2023) · Vestnik dermatologii i venerologii · doi:10.25208/vdv4775 · Cited by 4
Management of Plaque Psoriasis in Adults: Clinical Utility of Tapinarof Cream
Spencer, R. K., Jin, J. Q., Elhage, K. G., Davis, M. S., Liao, W. J., & Bhutani, T. (2023) · Psoriasis Targets and Therapy · doi:10.2147/ptt.s393997 · Cited by 3
Zobiri, O., Zucchi, H., Dimitrov, A., & Marrot, L. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.05.1091 · Cited by 4
Biological Therapies for Pediatric Atopic Dermatitis - A Review
Milano, G., Forestieri, S., Tedeschi, M., Licari, A., Brazzelli, V., & Marseglia, G. L. (2023) · Current Pediatric Reviews · doi:10.2174/1573396320666230912103136 · Cited by 4
Biologics for Allergic Dermatologic Diseases
Bilimoria, S. N., & Lio, P. (2020) · Current Allergy and Asthma Reports · doi:10.1007/s11882-020-00923-7 · Cited by 3
Topical treatments for eczema: a network meta-analysis
Yew, Y. W., Zheng, Q., Kok, W. L., Ho, M. S. L., Teoh, J. Y., Wong, Y., Shi, L., & Chan, E. S. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013205 · Cited by 3
RetractedJustiniano, R., & Wondrak, G. T. (2016) · Springer eBooks · doi:10.1007/978-3-319-43157-4_16 · Cited by 3
The dual roles of T cells and keratinocytes in seborrheic dermatitis: a narrative review
Xu, Y., & Tong, X. (2025) · European journal of medical research · doi:10.1186/s40001-025-03005-4 · Cited by 3
Effects of the dipeptide L-glutamic acid-L-tryptophan on dermatitis in mice and human keratinocytes
Shibata, S., Kuwahara, A., Sakaki‐Yumoto, M., Kawaguchi, M., Ishii, T., & Honma, Y. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e08729 · Cited by 2
Armstrong, A. W., & McConaha, J. L. (2023) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2023.29.12-a.s2 · Cited by 2
Globale Umweltveränderungen und die „epithelial barrier hypothesis“
Engelbert, N., Rohayem, R., & Traidl‐Hoffmann, C. (2024) · Die Dermatologie · doi:10.1007/s00105-023-05286-4 · Cited by 2
Gupta, A. A., Sasse, S. K., Gruca, M. A., Sanford, L., Dowell, R. D., & Gerber, A. N. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.23.432311 · Cited by 2
Influences of environmentally hazardous substances on atopic dermatitis: a review
Yu, S. Y., Kim, S. H., Choo, J. H., & Hwang, S. Y. (2025) · Molecular & Cellular Toxicology · doi:10.1007/s13273-025-00529-y · Cited by 2
Heinemann, N., Rademacher, F., Vollert, H., Gläser, R., & Harder, J. (2026) · Scientific Reports · doi:10.1038/s41598-026-50000-8 · Cited by 1
Chen, N., Yue, Y., & Zhou, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1879634 · Cited by 2
Advances in Therapy for Atopic Dermatitis
Zhou, N. Y., Bilimoria, S. N., & Lio, P. (2022) · Journal of the Dermatology Nurses’ Association · doi:10.1097/jdn.0000000000000658 · Cited by 1
Immune mechanisms of atopic dermatitis and new approaches to targeted biological therapy
Потекаев, Н. Н., Tereshchenko, G. P., Khanferyan, R. A., & Леонидович, С. А. (2022) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2022-16-3-130-136 · Cited by 2
Krämer, U., & Behrendt, H. (2019) · Der Hautarzt · Cited by 1
Influence of Air Pollution on Skin
Saxena, S., & Honari, G. (2017) · CRC Press eBooks · doi:10.1201/9781315121048-20
Topical treatments for eczema: a network meta-analysis
Yew, Y. W., Zheng, Q., Kok, W. L., Ho, M. S. L., Teoh, J. Y., Wong, Y., Shi, L., & Chan, E. S. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013205.pub2
Influence of Air Pollution on Skin
Saxena, S., & Honari, G. (2017) · CRC Press eBooks · doi:10.1201/9781315121048-26
Advances in Current Drugs and Formulations for the Management of Atopic Dermatitis
Atluri, K., Manne, S., Nalamothu, V., Mantel, A., Sharma, P. K., & Babu, R. J. (2023) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.2023042979
Allergien im Lichte globaler Umweltveränderungen
Orasche, J., Luschkova, D., & Traidl‐Hoffmann, C. (2024) · Die Dermatologie · doi:10.1007/s00105-023-05287-3
Kozlova, I. V., Chikin, V. V., Gorodnichev, P. V., Lagun, K. M., & Nosov, N. Y. (2025) · Vestnik dermatologii i venerologii · doi:10.25208/vdv16839
Kim, Y.-L., Roh, K., Jeon, K., Ryu, D., Jang, Y., Cho, E., Park, D., & Jung, E. (2026) · 생약학회지 · doi:10.22889/kjp.2026.57.1.71
Zhen, Y., Li, Q., Hu, X., Liu, X., Shao, Z., Xie, H. Q., Zhao, B., & Xu, S. L. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083530
Li, Z., Deng, C., Lu, B., Chen, F., Cao, X., Fan, J., & Song, Y. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1840065
Pattarapipatkul, N., Kasemcholathan, S., Cheevarungnapakul, K., Paemanee, A., Sirijan, M., Paiboonsukwong, K., & Sirikantaramas, S. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107450
The skin microbiome in aging from ecological dysbiosis to molecular therapeutics
Lei, Y., Liu, Q., & Lu, Q. (2026) · Microbiome Research Reports · doi:10.20517/mrr.2026.42
Metadata
- Authors
- Furue, M., Tsuji, G., Mitoma, C., Nakahara, T., Chiba, T., Morino-Koga, S., & Uchi, H.
- Affiliations
- Kyushu University (JP)
- Venue
- Journal of Dermatological Science
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 80
- Issue
- 2
- Pages
- 83-88
- ISSN
- 0923-1811 (ISSN-L)
- OpenAlex
- W2196195787
- Cited by
- 132
- References
- 50
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 12 · 2023: 17 · 2022: 20 · 2021: 17 · 2020: 11 · 2019: 14 · 2018: 13 · 2017: 13 · 2016: 5
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dermatological Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- aryl hydrocarbon receptor, filaggrin, skin barrier proteins, skin barrier, gene expression regulation, oxidative stress, antioxidant signaling, NF-E2-related factor 2, dioxins, tryptophan photoproducts, coal tar, flavonoids, transcriptional activation
- MeSH terms
- Polychlorinated Dibenzodioxins, Filaggrin Proteins, Animals, Coal Tar, Environmental Pollutants, Gene Expression Regulation, Humans, Intermediate Filament Proteins, Malassezia, Permeability, Skin, Transcription, Genetic, Ultraviolet Rays, Receptors, Aryl Hydrocarbon, Oxidative Stress, NF-E2-Related Factor 2, Hypoxia-Inducible Factor 1, alpha Subunit, Phytochemicals
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review