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Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor
Abstract
Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological effects by inducing the transcription of various AHR-responsive genes such as epidermal barrier proteins. The activation of AHR usually generates oxidative stress. However, AHR also mediates antioxidant signaling by a plethora of ligands via nuclear factor-erythroid 2-related factor-2. Both oxidative and antioxidant ligands upregulate the expression of the filaggrin gene. We review the role of AHR signaling in the gene regulation of epidermal barrier proteins.
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“Various herbal and antioxidant phytochemicals have been shown to activate AHR [16,17,19].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [17]
In the citing paper
“In addition to CYP1A1 induction, AHR is an essential transcription factor for human epidermal barrier proteins including FLG and LOR [17,28,29].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [17]
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Metadata
- Authors
- Furue, M., Tsuji, G., Mitoma, C., Nakahara, T., Chiba, T., Morino-Koga, S., & Uchi, H.
- Affiliations
- Kyushu University (JP)
- Venue
- Journal of Dermatological Science
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 80
- Issue
- 2
- Pages
- 83-88
- ISSN
- 0923-1811 (ISSN-L)
- OpenAlex
- W2196195787
- Cited by
- 132
- References
- 50
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 12 · 2023: 17 · 2022: 20 · 2021: 17 · 2020: 11 · 2019: 14 · 2018: 13 · 2017: 13 · 2016: 5
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dermatological Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- aryl hydrocarbon receptor, filaggrin, skin barrier proteins, skin barrier, gene expression regulation, oxidative stress, antioxidant signaling, NF-E2-related factor 2, dioxins, tryptophan photoproducts, coal tar, flavonoids, transcriptional activation
- MeSH terms
- Polychlorinated Dibenzodioxins, Filaggrin Proteins, Animals, Coal Tar, Environmental Pollutants, Gene Expression Regulation, Humans, Intermediate Filament Proteins, Malassezia, Permeability, Skin, Transcription, Genetic, Ultraviolet Rays, Receptors, Aryl Hydrocarbon, Oxidative Stress, NF-E2-Related Factor 2, Hypoxia-Inducible Factor 1, alpha Subunit, Phytochemicals
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