The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor
Abstract
Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological effects by inducing the transcription of various AHR-responsive genes such as epidermal barrier proteins. The activation of AHR usually generates oxidative stress. However, AHR also mediates antioxidant signaling by a plethora of ligands via nuclear factor-erythroid 2-related factor-2. Both oxidative and antioxidant ligands upregulate the expression of the filaggrin gene. We review the role of AHR signaling in the gene regulation of epidermal barrier proteins.
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In the citing paper
“Various herbal and antioxidant phytochemicals have been shown to activate AHR [16,17,19].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [17]
In the citing paper
“In addition to CYP1A1 induction, AHR is an essential transcription factor for human epidermal barrier proteins including FLG and LOR [17,28,29].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [17]
Citations
Cites
Functional role of AhR in the expression of toxic effects by TCDD
Mimura, J., & Fujii‐Kuriyama, Y. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00485-3 · Cited by 754
Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E., & Zhao, B. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr218 · Cited by 748
The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor
Nguyen, L. P., & Bradfield, C. A. (2007) · Chemical Research in Toxicology · doi:10.1021/tx7001965 · Cited by 718
Aryl hydrocarbon receptors: diversity and evolution
Hahn, M. E. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00070-4 · Cited by 642
Fritsche, E., Schäfer, C., Calles, C., Bernsmann, T., Bernshausen, T., Wurm, M., Hübenthal, U., Cline, J. E., Hajimiragha, H., Schroeder, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701764104 · Cited by 437
The cancer chemopreventive actions of phytochemicals derived from glucosinolates
Hayes, J. D., Kelleher, M., & Eggleston, I. M. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-2009-8 · Cited by 404
Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis
van den Bogaard, E. H., Bergboer, J. G. M., Vonk-Bergers, M., van Vlijmen-Willems, I. M. J. J., Hato, S. V., van der Valk, P. G. M., Schröder, J. M., Joosten, I., Zeeuwen, P. L. J. M., & Schalkwijk, J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65642 · Cited by 373
Lesions of Aryl-hydrocarbon Receptor–deficient Mice
Fernández‐Salguero, P. M., Ward, J. M., Sundberg, J. P., & Gonzalez, F. J. (1997) · Veterinary Pathology · doi:10.1177/030098589703400609 · Cited by 352
Kypriotou, M., Huber, M., & Hohl, D. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01472.x · Cited by 338
Quercetin regulates Th1/Th2 balance in a murine model of asthma
Park, H.-J., Lee, C., Jung, I. D., Lee, J. S., Jeong, Y.-I., Chang, J. H., Chun, S.-H., Kim, M., Choi, I., Ahn, S., et al. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.10.021 · Cited by 228
Cited by
Sorted by citations
Atopic Dermatitis: Pathophysiology
Boothe, W. D., Tarbox, J. A., & Tarbox, M. B. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-64804-0_3 · Cited by 478
Furue, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155382 · Cited by 419
Self-citationTapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans.
Smith, S. H., Jayawickreme, C., Rickard, D. J., Nicodeme, E., Bui, T., Simmons, C., Coquery, C. M., Neil, J., Pryor, W. M., Mayhew, D., et al. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.05.004 · Cited by 387
Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies
Furue, M., Chiba, T., Tsuji, G., Ulzii, D., Kido‐Nakahara, M., Nakahara, T., & Kadono, T. (2017) · Allergology International · doi:10.1016/j.alit.2016.12.002 · Cited by 324
Self-citationThe translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment
Facheris, P., Jeffery, J., DUCA, E. D., & Guttman‐Yassky, E. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-00992-4 · Cited by 255
Metadata
- Authors
- Furue, M., Tsuji, G., Mitoma, C., Nakahara, T., Chiba, T., Morino-Koga, S., & Uchi, H.
- Affiliations
- Kyushu University (JP)
- Venue
- Journal of Dermatological Science
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 80
- Issue
- 2
- Pages
- 83-88
- ISSN
- 0923-1811 (ISSN-L)
- OpenAlex
- W2196195787
- Cited by
- 132
- References
- 50
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 12 · 2023: 17 · 2022: 20 · 2021: 17 · 2020: 11 · 2019: 14 · 2018: 13 · 2017: 13 · 2016: 5
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dermatological Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- aryl hydrocarbon receptor, filaggrin, skin barrier proteins, skin barrier, gene expression regulation, oxidative stress, antioxidant signaling, NF-E2-related factor 2, dioxins, tryptophan photoproducts, coal tar, flavonoids, transcriptional activation
- MeSH terms
- Polychlorinated Dibenzodioxins, Filaggrin Proteins, Animals, Coal Tar, Environmental Pollutants, Gene Expression Regulation, Humans, Intermediate Filament Proteins, Malassezia, Permeability, Skin, Transcription, Genetic, Ultraviolet Rays, Receptors, Aryl Hydrocarbon, Oxidative Stress, NF-E2-Related Factor 2, Hypoxia-Inducible Factor 1, alpha Subunit, Phytochemicals
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