Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine

Al-Adhroey, Abdulelah H.; Nor, Zurainee M.; Al-Mekhlafi, Hesham M.; Amran, Adel A.; Mahmud, Rohela

doi:10.1016/j.jep.2011.01.026

Cited by 49Phytochemical compounds biological activitiesCoconut Research and ApplicationsMalaria Research and Control

Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine

Al-Adhroey, Abdulelah H., Nor, Zurainee M., Al-Mekhlafi, Hesham M., Amran, Adel A., Mahmud, Rohela·2011·Journal of Ethnopharmacology

DOI 10.1016/j.jep.2011.01.026

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Abstract

Ethnopharmacological relevance White flesh extract of Cocos nucifera (coconut) was studied to ascertain the ethnopharmacological standing of its antimalarial usage in Malaysian folk medicine.Materials and methods The crude methanol extract was investigated for phytochemical constituents and acute oral toxicity. Antimalarial activity of different extract doses of 50, 100, 200 and 400mg/kg were investigated in vivo against Plasmodium berghei (NK65) infections in mice during early, established and residual infections. Chloroquine (20mg/kg) and pyrimethamine (1.2mg/kg) were used as reference drugs.Results The results revealed that the extract contained some phytochemical constituents and is toxicologically safe by oral administration. The extract significantly reduced the parasitaemia by the 200 and 400mg/kg doses in the all three in vivo assessment assays. However, the extract did not significantly increase the survival time of the infected mice.Conclusions The observed pharmacological activities suggest that the Malaysian folkloric medicinal application of Cocos nucifera has a pharmacological basis.

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A decoction of the white flesh of the fruit is used in rural Malaysia to treat fever and malaria.
“A decoction of the white flesh of the fruit is used in rural Malaysia to treat fever and malaria (25).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [25]
The methanol white flesh extract of C. nucifera produced a dose-dependent chemotherapeutic activity in all three in vivo-assessment models against Plasmodium berghei (NK65) in mice.
“The methanol white flesh extract of C. nucifera produced a dose-dependent chemotherapeutic activity in all three in vivo-assessment models.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [25]
Chloroquine was much more effective at suppression and curing than the extract, and the extract did not increase the survival time of infected mice.
“however, chloroquine was much more effective at suppression and curing, and the extract did not increase the survival time of infected mice”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [25]
Five female and five male mice received a single dose orally (5000 mg/kg) of methanol extract of C. nucifera endocarp; no signs of toxicity and mortality were recorded, and all animals gained weight.
“Five female and five male mice received a single dose orally (5000 mg/kg) of this extract. All male and female rats were observed for signs of toxicity and mortality on the day of dosing; at 1, 3, and 4 h after administration; and then twice daily for 14 days. No signs of toxicity and mortality were recorded, and all animals gained weight during the observation period.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [25]

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GC-MS Characterization of Phyto-Components in the Ethanolic and Hydroalcoholic Extracts of Cocos nucifera Endocarp and Evaluation of their Antimalarial Potential
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Evaluation of the antiplasmodial and cytotoxicity potentials of husk fiber extracts from Cocos nucifera , a medicinal plant used in Nigeria to treat human malaria
Adebayo, J. O., Santána, A., & Krettli, A. U. (2012) · Human & Experimental Toxicology · doi:10.1177/0960327111424298 · Cited by 19 · see citing works

Authors: Al-Adhroey, A. H., Nor, Z. M., Al-Mekhlafi, H. M., Amran, A. A., & Mahmud, R.
Affiliations: University of Malaya (MY)
National University of Malaysia (MY)
ORCID: Nor, Zurainee M.
Amran, Adel A.
Venue: Journal of Ethnopharmacology
Publisher: Elsevier BV
Published: 2011-04
Volume: 134
Issue: 3
Pages: 988-991
ISSN: 0378-8741 (ISSN-L)
DOI: 10.1016/j.jep.2011.01.026
OpenAlex: W1978963240
Cited by: 49
References: 26
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 1 · 2015: 7 · 2014: 2 · 2013: 4 · 2012: 1
FWCI: 0.91
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Ethnopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: University of Malaya (PS204/2009C)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
Keywords: Cocos nucifera, coconut, antimalarial activity, Plasmodium berghei, parasitaemia reduction, phytochemical constituents, acute oral toxicity, medicinal plants, traditional medicine
MeSH terms: Ethanol, Animals, Antimalarials, Cocos, Dose-Response Relationship, Drug, Female, Malaria, Malaysia, Male, Medicine, Traditional, Plant Extracts, Plasmodium berghei, Mice

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Evaluation of the use of Cocos nucifera as antimalarial remedy in Malaysian folk medicine

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