Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies
Open accessAbstract
In this study, the antimalarial and toxicity potentials of husk fibre extracts of five Nigerian varieties of Cocos nucifera were evaluated in vitro . The only active extract fraction, West African Tall (WAT) ethyl acetate extract fraction, was then evaluated for its phytochemical constituents, antimalarial and toxicity potentials at varying doses (31.25–500 mg/kg body weight) using various organ function indices. The results revealed that WAT ethyl acetate extract fraction (WATEAEF) contained alkaloids, tannins, and flavonoids and was active against Plasmodium falciparum W2 strain maintained in continuous culture, with a selectivity index of 30.3. The same extract fraction was active in vivo against Plasmodium berghei NK65, causing more than 50% reduction in parasitaemia on days 4 and 6 after inoculation at various doses administered. WATEAEF did not significantly alter ( P > 0.05 ) function indices of the liver and cardiovascular system at all doses administered but significantly increased ( P < 0.05 ) plasma creatinine concentration at 250 and 500 mg/Kg body weight compared to controls. The results of this study suggest that WATEAEF possesses antimalarial activity and may not adversely affect normal liver function nor predispose subjects to cardiovascular diseases but may impair normal kidney function at higher doses. Further studies are underway to isolate the active principles.
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The phytochemicals present in WATEAEF were alkaloids, tannins, and flavonoids.
“The phytochemicals present in the WATEAEF were alkaloids, tannins, and flavonoids.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [65]
Treatment with 250 and 500 mg/kg body weight WATEAEF significantly increased plasma creatinine concentration compared with controls (P<0.05).
“Additionally, treatment with 250 and 500 mg/kg body weight WATEAEF significantly increased (P<0.05) plasma creatinine concentration compared with controls (65).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [65]
WATEAEF was active in vivo against P. berghei NK65, causing more than 50% reduction in parasitemia on days 4 and 6 after inoculation at various doses.
“The same extract fraction was active in vivo against P. berghei NK65, causing more than 50% reduction in parasitemia on days 4 and 6 after inoculation at various doses.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [65]
Only the West African Tall ethyl acetate extract fraction (WATEAEF) was active against P. falciparum W2 strain with a selectivity index of 30.3.
“The results showed that only the West African Tall ethyl acetate extract fraction (WATEAEF) was active against P. falciparum W2 strain with a selectivity index of 30.3.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [65]
Parasitemia varied on days 8 and 10, and results with WATEAEF were no better than with chloroquine.
“However, parasitemia varied on days 8 and 10, and results with WATEAEF were no better than with chloroquine.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [65]
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- Authors
- Adebayo, J. O., Balogun, E. A., Malomo, S. O., Soladoye, A. O., Olatunji, L. A., Kolawole, O. M., Oguntoye, O. S., Babatunde, A. S., Akinola, O. B., Aguiar, A. C. C., Andrade, I. M., Souza, N. B., & Krettli, A. U.
- Affiliations
- University of Ilorin (NG)
- Universidade Federal de Minas Gerais (BR)
- Fiocruz Minas (BR)
- Corresponding author
- Adebayo, J. O.
- ORCID
- Venue
- Evidence-Based Complementary and Alternative Medicine
- Publisher
- Wiley
- Published
- 2013
- Volume
- 2013
- Pages
- 1-9
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- PMC
- PMC3745858
- OpenAlex
- W2025720248
- Cited by
- 21
- References
- 46
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 2 · 2016: 1 · 2015: 3 · 2014: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Arca - Repositório Institucional da Fiocruz (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Ilorin
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Keywords
- Cocos nucifera, antimalarial activity, Plasmodium falciparum, Plasmodium berghei, ethyl acetate extract, phytochemical constituents, alkaloids, tannins, flavonoids, toxicity, renal function, serum creatinine, selectivity index, parasitaemia reduction
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