Evaluation of antiasthmatic activity of Clitoria ternatea L. roots
Abstract
Aim of study Clitoria ternatea L. (Family: Fabaceae) is being used in traditional medicine for the treatment of severe bronchitis and asthma. So the aim of study was to evaluate antiasthmatic activity of ethanol extract of Clitoria ternatea roots.Materials and methods In the present study ethanol extract of Clitoria ternatea root (ECTR) was evaluated for preliminary phytochemical screening, acute toxicity studies and antiasthmatic activity using milk induced leucocytosis and eosinophilia in mice, egg albumin induced mast cell degranulations in rats and passive cutaneous anaphylaxis in rats at doses (100-150 mg/kg ip).Results The results of present investigation showed that the LD(50) of ECTR is more than 1,300 mg/kg. ECTR significantly decreases milk induced leucocytosis and eosinophilia, protects egg albumin induced degranulations of mast cells in mice and inhibits area of blue dye leakage in passive cutaneous anaphylaxis in rats at (100-150 mg/kg, i.p.). Phytochemical studies observed the presence of steroids, saponin, flavonoids, and glycosides.Conclusion The present investigation concludes that the antiasthmatic activity of ECTR may be due to the presence of flavonoids or saponins.
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LD50 of ethanolic extract of C. ternatea root is more than 1300 mg/kg.
“Taur and Patil [146] reported LD50 of ethanolic extract of C. ternatea root to be more than 1300 mg/kg.”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [146]
Cites
Khare, C. P. (2007) · Springer eBooks · doi:10.1007/978-0-387-70638-2 · Cited by 10,636 · see citing works
Flavonoids, a class of natural products of high pharmacological potency
Havsteen, B. (1983) · Biochemical Pharmacology · doi:10.1016/0006-2952(83)90262-9 · Cited by 1,616 · see citing works
Screening Methods in Pharmacology
(1971) · Elsevier eBooks · doi:10.1016/c2013-0-11630-3 · Cited by 789 · see citing works
New Substances of Plant Origin Which Increase Nonspecific Resistance
Brekhman, I. I., & Dardymov, I. V. (1969) · Annual Review of Pharmacology · doi:10.1146/annurev.pa.09.040169.002223 · Cited by 595 · see citing works
Total Eosinophil Counts in the Management of Bronchial Asthma
Horn, B. R., Robin, E. D., Theodore, J., & Kessel, A. L. V. (1975) · New England Journal of Medicine · doi:10.1056/nejm197505292922204 · Cited by 393 · see citing works
Jain, N., Ohal, C. C., Shroff, S. K., Bhutada, R. H., Somani, R., Kasture, V. S., & Kasture, S. B. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00130-8 · Cited by 194 · see citing works
Immunological and Clinical Changes in Allergic Asthmatics following Treatment with Omalizumab
Noga, O., Hanf, G., & Kunkel, G. (2003) · International Archives of Allergy and Immunology · doi:10.1159/000070434 · Cited by 167 · see citing works
Anti-stress activity of Ocimum sanctum Linn.
Kp, B., & Singh, N. (1981) · PubMed · Cited by 162 · see citing works
Anti-inflammatory, analgesic and antipyretic properties of Clitoria ternatea root
Devi, B. P., Boominathan, R., & Mandal, S. C. (2003) · Fitoterapia · doi:10.1016/s0367-326x(03)00057-1 · Cited by 139 · see citing works
Studies of structure activity relationship of flavonoids for the anti-allergic actions
Cheong, H., Ryu, S., Oak, M., Cheon, S., Yoo, G., & Kim, K. (1998) · Archives of Pharmacal Research · doi:10.1007/bf02974647 · Cited by 131 · see citing works
Influence of Clitoria Ternatea Extracts on Memory and Central Cholinergic Activity in Rats
Taranalli, A. D., & Cheeramkuzhy, T. C. (2000) · Pharmaceutical Biology · doi:10.1076/1388-0209(200001)3811-bft051 · Cited by 119 · see citing works
Clitoria ternatea root extract enhances acetylcholine content in rat hippocampus
Rai, K. S., Murthy, K. D., Karanth, K. S., Nalini, K., Rao, M. S., & Srinivasan, K. K. (2002) · Fitoterapia · doi:10.1016/s0367-326x(02)00249-6 · Cited by 113 · see citing works
Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites
Hazekamp, A., Verpoorte, R., & Panthong, A. (2001) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(01)00320-8 · Cited by 80 · see citing works
Effect of leaves of Butea frondosa on stress, anxiety, and cognition in rats
Soman, I. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.05.022 · Cited by 62 · see citing works
Effect of alcoholic extract of Clitoria ternatea Linn. on central nervous system in rodents.
Kulkarni, C., Pattanshetty, & Amruthraj, G. (1988) · PubMed · Cited by 50 · see citing works
Antihistaminic and mast cell stabilizing activity of Striga orobanchioides
Harish, M., Nagur, M., & Badami, S. (2001) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(01)00236-7 · Cited by 38 · see citing works
The anti-allergic effects of Crinum glaucum aqueous extract
Okpo, S., & Adeyemi, O. (2002) · Phytomedicine · doi:10.1078/09447110260571698 · Cited by 28 · see citing works
Effect of quercetin and Albizzia saponins on rat mast cell.
Rk, J., Zutshi, U., Kameshwaran, L., & Ck, A. (1985) · PubMed · Cited by 28 · see citing works
ANTI-STRESS ACTIVITY OF OCIMUM SANCTUM
Kp, B., & Singh, N. P. (1981) · Cited by 25 · see citing works
Chemical examination ofClitoria ternatea seeds
Joshi, S. S., Shrivastava, R. K., & Shrivastava, D. K. (1981) · Journal of the American Oil Chemists Society · doi:10.1007/bf02899459 · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
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Oguis, G. K., Gilding, E. K., Jackson, M. A., & Craik, D. J. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.00645 · Cited by 289 · see citing works
Mehla, J., Gupta, P., Pahuja, M., Diwan, D., & Diksha, D. (2020) · Brain Sciences · doi:10.3390/brainsci10120964 · Cited by 108 · see citing works
Pharmacological importance of Clitoria ternatea - A review
Al‐Snafi, A. E. (2016) · Cited by 105 · see citing works
Verma, P. R., Itankar, P. R., & Arora, S. (2013) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2013000500015 · Cited by 69 · see citing works
A potential of Telang tree (Clitoria ternatea) in human health
Ezzudin, R. M., & Rabeta, M. S. (2018) · Food Research · doi:10.26656/fr.2017.2(5).073 · Cited by 54 · see citing works
Anti-allergy and anti-tussive activity of Clitoria ternatea L. in experimental animals
Singh, N. K., Garabadu, D., Sharma, P., Shrivastava, S. K., & Mishra, P. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.05.026 · Cited by 42 · see citing works
Suresh, S., Chhipa, A. S., Gupta, M., Lalotra, S., Sisodia, S. S., Baksi, R., & Nivsarkar, M. (2020) · South African Journal of Botany · doi:10.1016/j.sajb.2020.01.046 · Cited by 42 · see citing works
Damodaran, T. K., Tan, B. W. L., Liao, P. H., Ramanathan, S., Lim, G. K., & Hassan, Z. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.06.020 · Cited by 41 · see citing works
Huan, X., Wang, X., Zou, S., Zhao, K. X., Han, Y., & Wang, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010788 · Cited by 29 · see citing works
Norneolignans from the roots of Clitoria ternatea L.
Vasisht, K., Dhobi, M., Khullar, S., Mandal, S. K., & Karan, M. (2016) · Tetrahedron Letters · doi:10.1016/j.tetlet.2016.03.024 · Cited by 26 · see citing works
A Review Study on the Traditional Plants has Potential Antidepressant Property
Rahman, M. R. (2017) · MOJ Cell Science & Report · doi:10.15406/mojcsr.2017.04.00100 · Cited by 24 · see citing works
Baragob, A. E. A., Al‐Wabel, N. A., Ahmed, N. A. M., Babiker, M. A., Abdalkarim, A. S., & Elboshra, M. I. E. (2015) · Biochemistry and Biotechnology Research · Cited by 16 · see citing works
Awareness and Current Therapeutics of Asthma
Zainab, R., Akram, M., Daniyal, M., & Riaz, M. (2019) · Dose-Response · doi:10.1177/1559325819870900 · Cited by 16 · see citing works
Anti-anaphylactic and antiasthmatic activity of Euphorbia thymifolia L. on experimental animals
Parmar, G. R., Pundarikakshudu, K., & Balaraman, R. (2018) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2018.03.002 · Cited by 14 · see citing works
Sahoo, H., Sarangi, S., Kar, B., Mishra, N. K., Mohapatra, R., & Sagar, R. (2014) · International journal of Nutrition Pharmacology Neurological Diseases · doi:10.4103/2231-0738.129595 · Cited by 12 · see citing works
Sunita, P., Jha, S., & Pattanayak, S. P. (2012) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(12)60021-2 · Cited by 12 · see citing works
Morris, J. B., & Wang, M. L. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.07.014 · Cited by 10 · see citing works
Morris, J. B. (2022) · Journal of Dietary Supplements · doi:10.1080/19390211.2021.2022821 · Cited by 10 · see citing works
Nikolaichuk, H., Choma, I. M., & Morlock, G. E. (2023) · Molecules · doi:10.3390/molecules28072893 · Cited by 9 · see citing works
Goyal, S., Arora, J., & Ramawat, K. G. (2014) · Sustainable development and biodiversity · doi:10.1007/978-3-319-09381-9_11 · Cited by 9 · see citing works
New Norneolignan and Bioactive Constituents of Clitoria ternatea
Wu, F.-S., Hung, C.-J., Lin, C.-L., Chang, T.-H., Chen, C., Sung, P., Cheng, M., Huang, H.-Y., & Chen, J. (2020) · Chemistry of Natural Compounds · doi:10.1007/s10600-020-03213-w · Cited by 8 · see citing works
Comprehensive proteomic and metabolomic analysis uncover the response of okra to drought stress
Wang, J., Shi, D., Bai, Y., Zhang, T., Wu, Y., Liu, Z., Jiang, L. Z., Ye, L., Peng, Z., Yuan, H., et al. (2022) · PeerJ · doi:10.7717/peerj.14312 · Cited by 7 · see citing works
Kumar, D., & Dhobi, M. (2017) · Indian Journal of Pharmaceutical Sciences · doi:10.4172/pharmaceutical-sciences.1000322 · Cited by 7 · see citing works
Parmar, G. R., Pundarikakshudu, K., Balaraman, R., & Sailor, G. U. (2017) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1016/j.bjbas.2017.11.001 · Cited by 7 · see citing works
Achar, K. G. S., & Shivanna, M. B. (2013) · Archives of Phytopathology and Plant Protection · doi:10.1080/03235408.2012.755854 · Cited by 6 · see citing works
Biochemical and pharmacological aspects of Clitoria ternatea -A review
Kiran, Singh, A., & Jain, A. K. (2020) · Indian Journal of Agricultural Biochemistry · doi:10.5958/0974-4479.2020.00018.0 · Cited by 6 · see citing works
Antidiarrheal activity of Clitorea ternatea Linn. (Fabaceae) ethanol leaf extract in rats
Pandhare, R., Balakrishnan, S., Bangar, G., Dighe, P., & Deshmukh, V. K. (2018) · AYU (An International Quarterly Journal of Research in Ayurveda) · doi:10.4103/ayu.ayu_19_17 · Cited by 6 · see citing works
Bakhashwain, A. (2011) · Journal of Medicinal Plants Research · doi:10.5897/jmpr12.321 · Cited by 5 · see citing works
Boora, P., Puri, R., Rani, S., & Mehta, M. (2023) · Journal of Scientific Research · doi:10.3329/jsr.v15i3.63894 · Cited by 4 · see citing works
Universiti Teknologi, M. A. R. A., Alias, N. Z., FAISAL, N. A. M., Universiti Teknologi, M. A. R. A., Abdullah, S., Universiti Teknologi, M. A. R. A., ARSHAD, S., Universiti Teknologi, M. A. R. A., Murugaiyah, V., Malaysia, U. S., et al. (2023) · Journal of Sustainability Science and Management · doi:10.46754/jssm.2023.12.001 · Cited by 4 · see citing works
Lim, T. K. (2013) · Springer eBooks · doi:10.1007/978-94-007-7395-0_62 · Cited by 4 · see citing works
Sangeetha, V. J., Shankarappa, A., Satheesh, N. K., Raju, C. A., & Shwetha, S. (2026) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-026-04247-4 · Cited by 3 · see citing works
Tunna, T. S., Akter, M. S., Parvin, M., Jilhaz, M., Jahan, S., & Zaidul, I. S. M. (2020) · European Journal of Medical and Health Sciences · doi:10.24018/ejmed.2020.2.3.266 · Cited by 3 · see citing works
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Sreekala, S. R., & Muraleedharan, U. D. (2021) · Protein and Peptide Letters · doi:10.2174/0929866528666210922124735 · Cited by 3 · see citing works
Li, F., Zhou, N., Li, J.-J., Zhang, Y., & Zhao, X. Z. (2024) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2024.2365442 · Cited by 2 · see citing works
Botany, phytochemistry, pharmacology and application of Clitoria ternatea L.: a review
Wang, Y., Chen, H., Feng, P., Wang, D., & Du, X. (2025) · Records of Natural Products · doi:10.25135/rnp.2509.3634 · Cited by 2 · see citing works
Asthma: Types, Pathophysiology and Herbal remedies
Shinde, V., Patil, G., Patil, A., & Wankhede, P. (2023) · Asian Journal of Research in Pharmaceutical Sciences · doi:10.52711/2231-5659.2023.00028 · Cited by 2 · see citing works
Revitalization of Forage Seed Production in Indonesia
Purwantari, N. D. (2016) · Indonesian Bulletin of Animal and Veterinary Sciences · doi:10.14334/wartazoa.v26i1.1268 · Cited by 2 · see citing works
A Review on Medicinal Herbs with Potential Anti-Depressant Activities
Deshmukh, N. N., Vyas, J. V., Paithankar, V., & Wankhade, A. M. (2023) · Research Journal of Pharmacognosy and Phytochemistry · doi:10.52711/0975-4385.2023.00036 · Cited by 2 · see citing works
Clitoria ternatea L. (Fabaceae/Leguminosae)
Akbar, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-16807-0_70 · Cited by 1 · see citing works
Telange, D. R., Pandhare, P. V., Sawarkar, K., Mahajan, U. N., Ganorkar, S. B., & Warokar, A. S. (2024) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010326636240919094339 · Cited by 1 · see citing works
Zeng, Y., Xiong, Y., Li, J., Wu, K., Zeng, S., da Silva, J. A. T., & Ma, G. (2025) · Vegetos · doi:10.1007/s42535-025-01265-3 · Cited by 1 · see citing works
The Potential of Telang Flower (Clitoria ternatea) in Functional Food Diversification in Indonesia
Puspitojati, E. (2024) · Jurnal Ilmu-Ilmu Pertanian · doi:10.55259/jiip.v31i2.36 · Cited by 1 · see citing works
Raju, A. K., Unger, B. S., Hullatti, K., & Telagari, M. (2015) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2015.50819 · Cited by 1 · see citing works
Boora, P., Puri, R., Rani, S., Mehta, M., & Angmo, D. (2023) · Pharmacognosy Research · doi:10.5530/pres.15.2.041 · Cited by 1 · see citing works
Anxiolytics of natural origin II. Exotic plants
Navrátilová, Z. (2012) · Kontakt · doi:10.32725/kont.2012.022
Jena, J., Mahendrakar, S., Sahu, D. R., Sahu, B., Patro, C. N., Sahoo, B. M., & Jammula, S. (2020) · Current Nanomaterials · doi:10.2174/2405461505999201026201917
Phytotherapeutics in Inflammatory Lung Diseases
El‐Nashar, H. A. S., Fahmy, N. M., El‐Shazly, M., & Eldahshan, O. A. (2021) · Springer eBooks · doi:10.1007/978-981-33-6850-7_23
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Sarojini, T. S., Vadivelan, S., Manjuparkavi, K., Lalitha, V., Sethumathi, P. P., Praniga, K., Menaka, M., & Meena, T. S. P. (2022) · Annals of Phytomedicine An International Journal · doi:10.54085/ap.2022.11.2.32
Valvi, R., Takate, S. J., Pandhare, R., & Athare, A. E. (2026) · Discover Chemistry. · doi:10.1007/s44371-026-00632-6
Devi, D. R., Maheswari, S. N., Saranya, R. K., Aashritha, S., Sankar, N. G., Gurrala, N. A., Karak, P., & Das, S. K. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1922024
- Authors
- Taur, D. J., & Patil, R. Y.
- Corresponding author
- Taur, Dnyaneshwar J.
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 136
- Issue
- 2
- Pages
- 374-376
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W1975365040
- Cited by
- 56
- References
- 20
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 2 · 2020: 7 · 2019: 2 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- Clitoria ternatea, antiasthmatic activity, root extract, ethanol extract, acute toxicity, eosinophilia, passive cutaneous anaphylaxis, flavonoids, saponins, phytochemical screening, traditional medicine
- MeSH terms
- Anaphylaxis, Animals, Eosinophilia, Female, Lethal Dose 50, Leukocyte Disorders, Leukocytosis, Male, Mast Cells, Phytotherapy, Milk, Plant Extracts, Skin Diseases, Cell Degranulation, Rats, Wistar, Plant Roots, Anti-Asthmatic Agents, Clitoria, Mice, Rats
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