Clitoria ternatea root extract enhances acetylcholine content in rat hippocampus
Abstract
Treatment with 100 mg/kg of Clitoria ternatea aqueous root extract (CTR), for 30 days in neonatal and young adult age groups of rat, significantly increased acetylcholine (ACh) content in their hippocampi as compared to age matched controls. Increase in ACh content in their hippocampus may be the neurochemical basis for their improved learning and memory.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The nootropic activity of methanolic extract of aerial parts of Clitoria ternatea (100 mg/kg, p.o) has been reported using elevated plus maze and the object recognition test in rats.
“The nootropic activity of methanolic extract of aerial parts of C. ternatea (100 mg/kg, p.o) has been reported by using elevated plus maze and the object recognition test in rats [139].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [139]
Cites
Khare, C. P. (2007) · Springer eBooks · doi:10.1007/978-0-387-70638-2 · Cited by 10,636 · see citing works
The cholinergic hypothesis of geriatric memory dysfunction
Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545 · see citing works
Dhar, P., & DHAR, D. N. (2019) · WORLD SCIENTIFIC eBooks · doi:10.1142/11358 · Cited by 607 · see citing works
Ayurvedic Drugs and Their Plant Sources
Kite, G. C., Sivarajan, V. V., & Balachandran, I. (1995) · Kew Bulletin · doi:10.2307/4110353 · Cited by 578 · see citing works
Narang, A. (2019) · International Journal of Advanced Multidisciplinary Research · doi:10.22192/ijamr.2019.06.02.013 · Cited by 444 · see citing works
Harborne, J. B. (1973) · Springer eBooks · doi:10.1007/978-94-009-5921-7_1 · Cited by 349 · see citing works
Influence of Clitoria Ternatea Extracts on Memory and Central Cholinergic Activity in Rats
Taranalli, A. D., & Cheeramkuzhy, T. C. (2000) · Pharmaceutical Biology · doi:10.1076/1388-0209(200001)3811-bft051 · Cited by 119 · see citing works
Rhodes, M. E., Li, P., Flood, J. F., et al. (1996) · Brain Research · doi:10.1016/0006-8993(96)00751-2 · Cited by 88 · see citing works
Moore, H. M., Stuckman, S. S., Sarter, M. F., & Bruno, J. P. (1995) · Synapse · doi:10.1002/syn.890210407 · Cited by 73 · see citing works
Effect of alcoholic extract of Clitoria ternatea Linn. on central nervous system in rodents.
Kulkarni, C., Pattanshetty, & Amruthraj, G. (1988) · PubMed · Cited by 50 · see citing works
Fellman, J. H. (1969) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1969.tb05932.x · Cited by 47 · see citing works
Nishizaki, T., Matsuoka, T., Nomura, T., Kondoh, T., Watabe, S., Shiotani, T., & Yoshii, M. (2000) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200000001-00013 · Cited by 19 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Ayurvedic medicine Clitoria ternatea—From traditional use to scientific assessment
Mukherjee, P. K., Kumar, V., Kumar, N. S., & Heinrich, M. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.09.009 · Cited by 369 · see citing works
Ayurvedic medicinal plants for Alzheimer’s disease: A review
Rao, R. V., Descamps, O., John, V., & Bredesen, D. E. (2012) · Alzheimer's Research & Therapy · doi:10.1186/alzrt125 · Cited by 213 · see citing works
Mehla, J., Gupta, P., Pahuja, M., Diwan, D., & Diksha, D. (2020) · Brain Sciences · doi:10.3390/brainsci10120964 · Cited by 108 · see citing works
Mohandas Rao, K. G., Muddanna Rao, S., & Gurumadhva Rao, S. (2006) · Evidence-Based Complementary and Alternative Medicine · doi:10.1093/ecam/nel024 · Cited by 103 · see citing works
“Clitoria ternatea has been shown to enhance acetylcholine content in the rat hippocampus (32).”
BackgroundSelf-citationEvaluation of antiasthmatic activity of Clitoria ternatea L. roots
Taur, D. J., & Patil, R. Y. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.04.064 · Cited by 56 · see citing works
Rai, K. S., Murthy, K. D., Rao, M. S., & Karanth, K. S. (2005) · Phytotherapy Research · doi:10.1002/ptr.1657 · Cited by 39 · see citing works
Self-citationMehla, J., Pahuja, M., Gupta, P., Dethe, S., Agarwal, A., & Gupta, Y. K. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3185-7 · Cited by 29 · see citing works
- Authors
- Rai, K. S., Murthy, K. D., Karanth, K. S., Nalini, K., Rao, M. S., & Srinivasan, K. K.
- Affiliations
- Kasturba Medical College, Manipal (IN)
- K S Hegde Medical Academy (IN)
- Manipal Academy of Higher Education (IN)
- Venue
- Fitoterapia
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 73
- Issue
- 7-8
- Pages
- 685-689
- ISSN
- 0367-326X (ISSN-L)
- OpenAlex
- W2034634766
- Cited by
- 113
- References
- 12
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 9 · 2022: 3 · 2021: 14 · 2020: 9 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 8 · 2015: 7 · 2014: 3 · 2013: 5 · 2012: 8
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Fitoterapia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kasturba Medical College, Manipal
- Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Clitoria ternatea, root extract, acetylcholine, hippocampus, cholinergic neurotransmitters, learning and memory, age-dependent effects
- MeSH terms
- Acetylcholine, Aging, Animals, Animals, Newborn, Female, Hippocampus, Learning, Male, Memory, Plant Extracts, Rats, Wistar, Plant Roots, Clitoria, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
