Synthesis and incorporation of rod-like nano-hydroxyapatite into type I collagen matrix: a hybrid formulation for 3D printing of bone scaffolds
Open accessAbstract
Over the recent years, nanometric hydroxyapatite (HA) has gained interest as constituent of hybrid systems for bone scaffold fabrication, due to its biomimicry and biocompatibility. In this study, rod-like nano-HA particles were introduced in a type I collagen matrix to create a composite mimicking the bone composition. HA nano-rods (40−60 nm × 20 nm) were synthesised by hydrothermal method involving the use of an ammonium-based dispersing agent (Darvan 821-A) and fully characterised. The homogeneous dispersion of HA nanoparticles throughout the final hybrid formulation was achieved through their suspension in a collagen solution in presence of Darvan 821-A. The resulting homogeneous collagen/nano-HA suspension proved to be suitable for extrusion printing applications, showing shear thinning and sol-gel transition upon simil-physiological conditions. Furthermore, mesh-like structures were printed in a gelatine-supporting bath by means of a commercial bioprinter further demonstrating the potential of the designed hybrid system for the fabrication of 3D bone-like scaffolds.
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A biomimetic nano-HA/collagen scaffold (65 wt.% and 35 wt.%) showed natural bone architecture that facilitates adhesion, proliferation and differentiation.
“Biomimietic scaffold showed natural bone architecture which facilitates adhesion, proliferation and differentiation.[108]”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [108]
Section 2.3 confirms that the collagen/nano-HA formulation contained 65 wt% nano-HA and 35 wt% collagen to mimic natural bone composition. But the Conclusions say reproducing natural bone architecture was planned for future work, and the constructs’ ability to promote cell adhesion, proliferation, and differentiation had yet to be investigated. The paper therefore does not support the claim that the scaffold had already shown those properties. (LLM, conf=0.90)
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Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration.
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Self-citation
- Authors
- Montalbano, G., Molino, G., Fiorilli, S., & Vitale-Brovarone, C.
- Affiliations
- Politecnico di Torino (IT)
- Venue
- Journal of the European Ceramic Society
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 40
- Issue
- 11
- Pages
- 3689-3697
- ISSN
- 0955-2219 (ISSN-L)
- OpenAlex
- W3005469806
- Cited by
- 84
- References
- 39
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 9 · 2023: 13 · 2022: 16 · 2021: 23 · 2020: 6
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of the European Ceramic Society (publishedVersion, cc-by-nc-nd)
- PORTO@Iris (submittedVersion, cc-by-nc-nd)
- INFM-OAR (INFN Catania) (submittedVersion, cc-by-nc-nd)
- Funders
- European Research Council
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Horizon 2020 Framework Programme
- Horizon 2020 (681798-BOOST)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Automotive Engineering › Additive Manufacturing and 3D Printing Technologies
- Keywords
- type I collagen, bone scaffolds, 3D bioprinting, extrusion printing, hydrothermal synthesis, shear thinning, sol-gel transition, bone tissue engineering
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