Polyphenols with antiglycation activity and mechanisms of action: A review of recent findings
Open accessAbstract
Advanced glycation end products (AGEs) are substances composed of amino groups of proteins and reducing sugars. The initial and propagation phases of the glycation process are accompanied by the production of a large amount of free radicals, carbonyl species, and reactive dicarbonyl species, of which, methylglyoxal (MG) is the most reactive and can cause dicarbonyl stress, influencing normal physiological functions. In the advanced phase, the production of AGEs and the interaction between AGEs and their receptor, RAGE, are also considered to be among the causes of chronic diseases, oxidative stress, and inflammatory reaction. Till date, multiple physiological activities of polyphenols have been confirmed. Recently, there have been many studies discussing the ability of polyphenols to suppress the MG and AGEs formation, which was also confirmed in some in vivo studies. This review article collects recent literatures concerning the effects of polyphenols on the generation of MG and AGEs through different pathways and discusses the feasibility of the inhibition of glycative stress and dicarbonyl stress by polyphenols.
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Rice (Oryza sativa L.) and blueberry exhibit antiglycation activities.
“such rice (Oryza sativa L.), and blueberry, exhibit antiglycation activities.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [267]
Polyphenols such as gallic acid, flavonoids, anthocyanin, and ferulic acid attenuate protein glycation and prevent the biosynthesis of AGEs.
“These foods are rich in polyphenols such as gallic acid, flavonoids, anthocyanin, and ferulic acid, which attenuate protein glycation and prevent the biosynthesis of AGEs265–270.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [267]
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Rungratanawanich, W., Qu, Y., Wang, X., Essa, M. M., & Song, B.-J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00561-7 · Cited by 411 · see citing works
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- Authors
- Yeh, W.-J., Hsia, S.-M., Lee, W.-H., & Wu, C.-H.
- Affiliations
- Taipei Medical University (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Venue
- Journal of Food and Drug Analysis
- Published
- 2017-01
- Volume
- 25
- Issue
- 1
- Pages
- 84-92
- ISSN
- 1021-9498 (ISSN-L)
- PMC
- PMC9333423
- OpenAlex
- W2559144644
- Cited by
- 353
- References
- 72
- Citations by year
- 2026: 28 · 2025: 36 · 2024: 36 · 2023: 43 · 2022: 41 · 2021: 51 · 2020: 38 · 2019: 46 · 2018: 29 · 2017: 4 · 2014: 1
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Food and Drug Analysis (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Ministry of Science and Technology, Taiwan, Republic of China (MOST103-2313-B-038-001-MY3, 101-2313-B-038-006-MY2)
- Taipei Medical University-Shuang Ho Hospital, Taiwan (103TMU-SHH-07)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- polyphenols, advanced glycation end products, methylglyoxal, dicarbonyl stress, glycation, receptor for advanced glycation end products, oxidative stress, inflammation, chronic disease, mechanism of action
- MeSH terms
- Free Radicals, Pyruvaldehyde, Glycation End Products, Advanced, Oxidative Stress, Polyphenols
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