Dicarbonyl proteome and genome damage in metabolic and vascular disease

Global quantification of mammalian gene expression control

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Endogenous DNA damage in humans: a review of quantitative data

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Oxidative damage to DNA in diabetes mellitus

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Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin.

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Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry

Thornalley, P. J., Battah, S., Ahmed, N., Karachalias, N., Agalou, S., Babaei‐Jadidi, R., & Dawnay, A. (2003) · Biochemical Journal · doi:10.1042/bj20030763 · Cited by 659 · see citing works

N ε-(Carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins

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Action des acides amines sur les sucres : formation des melanoidines par voie methodique

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The glyoxalase system in health and disease

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Age-related differences in fat-free mass, skeletal muscle, body cell mass and fat mass between 18 and 94 years

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Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome

Rabbani, N., & Thornalley, P. J. (2010) · Amino Acids · doi:10.1007/s00726-010-0783-0 · Cited by 431 · see citing works

Role of the Maillard Reaction in Aging of Tissue Proteins

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Structure of hemoglobin AIc: Nature of the N-terminal β chain blocking group

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Peptide Mapping Identifies Hotspot Site of Modification in Human Serum Albumin by Methylglyoxal Involved in Ligand Binding and Esterase Activity

Ahmed, N., Dobler, D., Dean, M., & Thornalley, P. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410973200 · Cited by 314 · see citing works

Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation

Xue, M., Rabbani, N., Momiji, H., Imbasi, P., Anwar, M. M., Kitteringham, N. R., Park, B. K., Souma, T., Moriguchi, T., Yamamoto, M. P., et al. (2011) · Biochemical Journal · doi:10.1042/bj20111648 · Cited by 302 · see citing works

Methylglyoxal-Derived Hydroimidazolone Advanced Glycation End-Products of Human Lens Proteins

Ahmed, N., Thornalley, P. J., Dawczynski, J., Franke, S., Strobel, J., Stein, G., & HAIK, G. M. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0573 · Cited by 282 · see citing works

Protein Modification by Methylglyoxal: Chemical Nature and Synthetic Mechanism of a Major Fluorescent Adduct

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Glyoxalase‐1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans

Morcos, M., Du, X., Pfisterer, F., Hutter, H., Sayed, A. A. R., Thornalley, P. J., Ahmed, N., Baynes, J., Thorpe, S. R., Kukudov, G., et al. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00371.x · Cited by 276 · see citing works

Increased Dicarbonyl Metabolism in Endothelial Cells in Hyperglycemia Induces Anoikis and Impairs Angiogenesis by RGD and GFOGER Motif Modification

Dobler, D., Ahmed, N., Song, L., Eboigbodin, K. E., & Thornalley, P. J. (2006) · Diabetes · doi:10.2337/db05-1634 · Cited by 269 · see citing works

Accumulation of α-oxoaldehydes during oxidative stress: a role in cytotoxicity

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Modification of the glyoxalase system in human red blood cells by glucose in vitro

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Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment

Ahmed, N., Ahmed, U., Thornalley, P. J., Häger, K., Fleischer, G., & Münch, G. W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02864.x · Cited by 238 · see citing works

Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetes

Ahmed, N., Babaei‐Jadidi, R., Howell, S. K., Beisswenger, P. J., & Thornalley, P. J. (2005) · Diabetologia · doi:10.1007/s00125-005-1810-7 · Cited by 237 · see citing works

High Glucose Increases Angiopoietin-2 Transcription in Microvascular Endothelial Cells through Methylglyoxal Modification of mSin3A

Yao, D., Taguchi, T., Matsumura, T., Pestell, R. G., Edelstein, D., Giardino, I., Suske, G., Rabbani, N., Thornalley, P. J., Sarthy, V. P., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704703200 · Cited by 233 · see citing works

Kinetics and mechanism of the reaction of aminoguanidine with the α-oxoaldehydes glyoxal, methylglyoxal, and 3-deoxyglucosone under physiological conditions

Thornalley, P. J., Yurek‐George, A., & Argirov, O. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00287-2 · Cited by 214 · see citing works

A fast method to predict protein interaction sites from sequences

Gallet, X., Charloteaux, B., Thomas, A., & Brasseur, R. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4092 · Cited by 212 · see citing works

Identification and Quantification of Major Maillard Cross-links in Human Serum Albumin and Lens Protein

Biemel, K. M., Friedl, D. A., & Lederer, M. O. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202681200 · Cited by 210 · see citing works

Advanced Glycation End Products in Extracellular Matrix Proteins Contribute to the Failure of Sensory Nerve Regeneration in Diabetes

Duran-Jimenez, B., Dobler, D., Moffatt, S., Rabbani, N., Streuli, C. H., Thornalley, P. J., Tomlinson, D. R., & Gardiner, N. J. (2009) · Diabetes · doi:10.2337/db09-0320 · Cited by 186 · see citing works

Knockdown of Glyoxalase 1 Mimics Diabetic Nephropathy in Nondiabetic Mice

Giacco, F., Du, X., D’Agati, V. D., Milne, R. W., Sui, G., Geoffrion, M., & Brownlee, M. (2013) · Diabetes · doi:10.2337/db13-0316 · Cited by 182 · see citing works

Glycation of LDL by Methylglyoxal Increases Arterial Atherogenicity

Rabbani, N., Godfrey, L., Xue, M., Shaheen, F., Geoffrion, M., Milne, R. W., & Thornalley, P. J. (2011) · Diabetes · doi:10.2337/db11-0085 · Cited by 167 · see citing works

Assay of advanced glycation endproducts in selected beverages and food by liquid chromatography with tandem mass spectrometric detection

Ahmed, N., Mirshekar-Syahkal, B., Kennish, L., Karachalias, N., Babaei‐Jadidi, R., & Thornalley, P. J. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500008 · Cited by 155 · see citing works

Chromatographic assay of glycation adducts in human serum albumin glycated in vitro by derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and intrinsic fluorescence

Ahmed, N., & Thornalley, P. J. (2002) · Biochemical Journal · doi:10.1042/bj3640015 · Cited by 154 · see citing works

Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase.

Delpierre, G., Rider, M. H., Collard, F., Stroobant, V., Vanstapel, F. J. L. A., Santos, H., & SCHAFTINGEN, E. V. (2000) · Diabetes · doi:10.2337/diabetes.49.10.1627 · Cited by 154 · see citing works

Profound Mishandling of Protein Glycation Degradation Products in Uremia and Dialysis

Agalou, S., Ahmed, N., Babaei‐Jadidi, R., Dawnay, A., & Thornalley, P. J. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004080635 · Cited by 150 · see citing works

Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes

Karachalias, N., Babaei‐Jadidi, R., Rabbani, N., & Thornalley, P. J. (2010) · Diabetologia · doi:10.1007/s00125-010-1722-z · Cited by 139 · see citing works

Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance

Thornalley, P. J., Waris, S., Fleming, T. H., Santarius, T., Larkin, S. J., Winklhofer‐Roob, B. M., Stratton, M. R., & Rabbani, N. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq306 · Cited by 125 · see citing works

Increased Glycation and Oxidative Damage to Apolipoprotein B100 of LDL Cholesterol in Patients With Type 2 Diabetes and Effect of Metformin

Rabbani, N., Chittari, M. V., Bodmer, C. W., Zehnder, D., Ceriello, A., & Thornalley, P. J. (2010) · Diabetes · doi:10.2337/db09-1455 · Cited by 122 · see citing works

Detection and identification of a protein-bound imidazolone resulting from the reaction of arginine residues and methylglyoxal

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Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress

Kurz, A., Rabbani, N., Walter, M. J., von Bonin, M., Thornalley, P. J., Auburger, G. W. J., & Gispert, S. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0483-7 · Cited by 90 · see citing works

Accumulation of free adduct glycation, oxidation, and nitration products follows acute loss of renal function

Rabbani, N., Sebekova, K., Sebekova, K., Heidland, A., & Thornalley, P. J. (2007) · Kidney International · doi:10.1038/sj.ki.5002513 · Cited by 90 · see citing works

Increased protein glycation in fructosamine 3-kinase-deficient mice

Veiga‐da‐Cunha, M., Jacquemin, P., Delpierre, G., Godfraind, C., Théate, I., Vertommen, D., Clotman, F., Lemaigre, F. P., Devuyst, O., & SCHAFTINGEN, E. V. (2006) · Biochemical Journal · doi:10.1042/bj20060684 · Cited by 84 · see citing works

Quantitative measurement of specific biomarkers for protein oxidation, nitration and glycation in Arabidopsis leaves

Bechtold, U., Rabbani, N., Mullineaux, P. M., & Thornalley, P. J. (2009) · The Plant Journal · doi:10.1111/j.1365-313x.2009.03898.x · Cited by 75 · see citing works

N2-carboxyethyl-2′-deoxyguanosine, a DNA glycation marker, in kidneys and aortas of diabetic and uremic patients

Li, H., Nakamura, S., Miyazaki, S., Morita, T., Suzuki, M., Pischetsrieder, M., & Niwa, T. (2006) · Kidney International · doi:10.1038/sj.ki.5000064 · Cited by 69 · see citing works

Processing of protein glycation, oxidation and nitrosation adducts in the liver and the effect of cirrhosis

Ahmed, N., Thornalley, P. J., Luthen, R. E., Häussinger, D., Šebeková, K., Schinzel, R., Voelker, W., & Heidland, A. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.08.007 · Cited by 67 · see citing works

Protein glycationin vivo: functional and structural effects on yeast enolase

Gomes, R. A., Oliveira, L. M. A., Silva, M. C. C., Ascenso, C. S., Quintas, A., da Costa, G., Coelho, A. V., Silva, M. S., Ferreira, A. E. N., Freire, A. P., et al. (2008) · Biochemical Journal · doi:10.1042/bj20080632 · Cited by 53 · see citing works

Glyoxalase II does not support methylglyoxal detoxification but serves as a general trypanothione thioesterase in African trypanosomes

Wendler, A., Irsch, T., Rabbani, N., Thornalley, P. J., & Krauth‐Siegel, R. L. (2008) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2008.09.005 · Cited by 40 · see citing works

Protein damage in diabetes and uremia—identifying hotspots of proteome damage where minimal modification is amplified to marked pathophysiological effect

Thornalley, P. J., & Rabbani, N. (2010) · Free Radical Research · doi:10.3109/10715762.2010.534162 · Cited by 38 · see citing works

Transduced Tat-glyoxalase protein attenuates streptozotocin-induced diabetes in a mouse model

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Observation of arterial and venous thrombus formation by scanning and transmission electron microscopy

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Permeability of inner mitochondrial membrane to arginine reagents

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Novel Amino Acid Metabolite Produced byStreptomycessp.: I. Taxonomy, Isolation, and Structural Elucidation

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Targeting Metabolism for Cancer Therapy

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Methylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related Diseases

Schalkwijk, C., & Stehouwer, C. D. A. (2019) · Physiological Reviews · doi:10.1152/physrev.00001.2019 · Cited by 630 · see citing works

Altered metabolite levels in cancer: implications for tumour biology and cancer therapy

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Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease

Rabbani, N., & Thornalley, P. J. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.140 · Cited by 353 · see citing works

Polyphenols with antiglycation activity and mechanisms of action: A review of recent findings

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A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling

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The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases

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Ferroptosis: bug or feature?

Dixon, S. J. (2017) · Immunological Reviews · doi:10.1111/imr.12533 · Cited by 314 · see citing works

Coordinated Actions of Glyoxalase and Antioxidant Defense Systems in Conferring Abiotic Stress Tolerance in Plants

Hasanuzzaman, M., Nahar, K., Hossain, M. S., Mahmud, J. A., Rahman, A., Inafuku, M., Oku, H., & Fujita, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010200 · Cited by 281 · see citing works

Methylglyoxal: An Emerging Signaling Molecule in Plant Abiotic Stress Responses and Tolerance

Hoque, T. S., Hossain, M. A., Mostofa, M. G., Burritt, D. J., Fujita, M., & Tran, L. P. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01341 · Cited by 247 · see citing works

Mechanistic targeting of advanced glycation end-products in age-related diseases

Rowan, S., Bejarano, E., & Taylor, A. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.036 · Cited by 218 · see citing works

Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention

Brings, S., Fleming, T. H., Freichel, M., Muckenthaler, M. U., Herzig, S., & Nawroth, P. P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18050984 · Cited by 204 · see citing works

Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments

Rabbani, N., Xue, M., & Thornalley, P. J. (2016) · Clinical Science · doi:10.1042/cs20160025 · Cited by 173 · see citing works

Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics

Rabbani, N., Xue, M., & Thornalley, P. J. (2016) · Glycoconjugate Journal · doi:10.1007/s10719-016-9705-z · Cited by 169 · see citing works

RAGE and Its Ligands: Molecular Interplay Between Glycation, Inflammation, and Hallmarks of Cancer—a Review

Palanissami, G., & Paul, S. F. D. (2018) · Hormones and Cancer · doi:10.1007/s12672-018-0342-9 · Cited by 171 · see citing works

Methylglyoxal Metabolism and Aging-Related Disease: Moving from Correlation toward Causation

Kold-Christensen, R., & Johannsen, M. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.10.003 · Cited by 128 · see citing works

Glyoxalase system: A systematic review of its biological activity, related-diseases, screening methods and small molecule regulators

He, Y., Zhou, C., Huang, M., Tang, C., Liu, X., Yue, Y., Diao, Q., Zheng, Z.-B., & Liu, D. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110663 · Cited by 131 · see citing works

Methylglyoxal-Glyoxalase 1 Balance: The Root of Vascular Damage

Nigro, C., Leone, A., Raciti, G. A., Longo, M., Mirra, P., Formisano, P., Bèguinot, F., & Miele, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010188 · Cited by 112 · see citing works

Mass spectrometric determination of early and advanced glycation in biology

Rabbani, N., Ashour, A. A., & Thornalley, P. J. (2016) · Glycoconjugate Journal · doi:10.1007/s10719-016-9709-8 · Cited by 98 · see citing works

Metformin Scavenges Methylglyoxal To Form a Novel Imidazolinone Metabolite in Humans

Kinsky, O. R., Hargraves, T. L., Anumol, T., Jacobsen, N. E., Dai, J., Snyder, S. A., Monks, T. J., & Lau, S. S. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5b00497 · Cited by 93 · see citing works

Dicarbonyl Stress at the Crossroads of Healthy and Unhealthy Aging

Nigro, C., Leone, A., Fiory, F., Prevenzano, I., Nicolò, A., Mirra, P., Bèguinot, F., & Miele, C. (2019) · Cells · doi:10.3390/cells8070749 · Cited by 91 · see citing works

Interplay among Oxidative Stress, Methylglyoxal Pathway and S-Glutathionylation

Lidia de, B. A. R. I., Scirè, A., Minnelli, C., Cianfruglia, L., Kalapos, M. P., & Armeni, T. (2020) · Antioxidants · doi:10.3390/antiox10010019 · Cited by 91 · see citing works

Vascular AGE-ing by methylglyoxal: the past, the present and the future

Schalkwijk, C. G. (2015) · Diabetologia · doi:10.1007/s00125-015-3597-5 · Cited by 87 · see citing works

Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of Action

Meloni, B. P., Mastaglia, F. L., & Knuckey, N. W. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00108 · Cited by 85 · see citing works

Multiple roles of glyoxalase 1-mediated suppression of methylglyoxal glycation in cancer biology—Involvement in tumour suppression, tumour growth, multidrug resistance and target for chemotherapy

Rabbani, N., Xue, M., Weickert, M. O., & Thornalley, P. J. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.05.006 · Cited by 82 · see citing works

Analysis of global gene expression profile of rice in response to methylglyoxal indicates its possible role as a stress signal molecule

Kaur, C., Kushwaha, H. R., Mustafiz, A., Pareek, A., Sopory, S. K., & Singla-Pareek, S. L. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00682 · Cited by 77 · see citing works

Dicarbonyl stress in clinical obesity

Masania, J., Malczewska-Malec, M., Raźny, U., Góralska, J., Zdzienicka, A., Kieć‐Wilk, B., Gruca, A., Stancel-Możwiłło, J., Dembinska-Kiec, A., Rabbani, N., et al. (2016) · Glycoconjugate Journal · doi:10.1007/s10719-016-9692-0 · Cited by 76 · see citing works

Pathogenesis and therapeutic strategy in platinum resistance lung cancer

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Impact of Advanced Glycation End products (AGEs) and its receptor (RAGE) on cancer metabolic signaling pathways and its progression

Muthyalaiah, Y. S., Jonnalagadda, B., John, C. M., & Arockiasamy, S. (2021) · Glycoconjugate Journal · doi:10.1007/s10719-021-10031-x · Cited by 72 · see citing works

A reaction-based fluorescent probe for the selective detection of formaldehyde and methylglyoxal via distinct emission patterns

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Diabetes with heart failure increases methylglyoxal modifications in the sarcomere, which inhibit function

Papadaki, M., Holewinski, R. J., Previs, S. B., Martin, T. G., Stachowski, M. J., Li, A., Blair, C. A., Moravec, C. S., Eyk, J. E. V., Campbell, K. S., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.121264 · Cited by 71 · see citing works

Dicarbonyl stress, protein glycation and the unfolded protein response

Rabbani, N., Xue, M., & Thornalley, P. J. (2021) · Glycoconjugate Journal · doi:10.1007/s10719-021-09980-0 · Cited by 67 · see citing works

Probing Protein Glycation by Chromatography and Mass Spectrometry: Analysis of Glycation Adducts

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The Dual-Role of Methylglyoxal in Tumor Progression – Novel Therapeutic Approaches

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Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes

Zhang, W., Randell, E. W., Sun, G., Likhodii, S. S., Liu, M., Furey, A. J., & Zhai, G. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184105 · Cited by 54 · see citing works

Glyoxalase 1-knockdown in human aortic endothelial cells – effect on the proteome and endothelial function estimates

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Formation of α-dicarbonyl compounds in cookies made from wheat, hull-less barley and colored corn and its relation with phenolic compounds, free amino acids and sugars

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