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Inhibitory effect of polyphenol-rich extracts of jute leaf (Corchorus olitorius) on key enzyme linked to type 2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting) in vitro
Open accessAbstract
Abstract Corchorus olitorius leaf is consumed in various parts of the world as leafy vegetable and folk remedy for the management of some degenerative diseases with dearth of information on its biochemical rationale. Therefore, this study sought to characterize the inhibitory action of polyphenol-rich extracts (free and bound) of C. olitorius on α-amylase, α-glucosidase and angiotensin I converting enzyme (ACE), as well as to identify the phenolic compound responsible for these activities. Our findings revealed that the extracts inhibited α-amylase and α-glucosidase (12.5–50.0 μg/mL), and ACE (10.0–50.0 μg/mL) in dose-dependently with free extracts having significantly ( P 50 . Reversed-phase HPLC analysis of the extracts revealed chlorogenic acid (7.5 mg/100 g) and isorhamnetin (51.1 mg/100 g) as the main phenolics in the free extract and caffeic acid (58.1 mg/100 g) in the bound extract. Therefore, the enzyme inhibitory activity of C. olitorius extracts may be attributed to the presence of caffeic acid, chlorogenic acid and isorhamnetin, thus justifying its use in folklore for the management of diabetes and hypertension.
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Cites
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Medicinal plants of India with anti-diabetic potential
Grover, J. K., Yadav, S., & Vats, V. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(02)00059-4 · Cited by 1,798
Chlorogenic Acid and Caffeic Acid Are Absorbed in Humans
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Antioxidant and Antiproliferative Activities of Common Vegetables
Chu, Y.-F., Sun, J., Wu, X., & Liu, R. H. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020665f · Cited by 937
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Li, N., Frigerio, F., & Maechler, P. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360930 · Cited by 114
Cited by
An update on natural compounds in the remedy of diabetes mellitus: A systematic review
Choudhury, H., Pandey, M., Hua, C. K., Mun, C. S., Jing, J. K., Kong, L., Ern, L. Y., Ashraf, N. A., Kit, S. W., Yee, T. S., et al. (2018) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2017.08.012 · Cited by 455
Oboh, G., Agunloye, O. M., Adefegha, S. A., Akinyemi, A. J., & Ademiluyi, A. O. (2015) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2013-0141 · Cited by 363
Self-citationÇam, M., İçyer, N. C., & Erdoğan, F. (2014) · LWT - Food Science and Technology · doi:10.1016/j.lwt.2013.09.011 · Cited by 342
Adefegha, S. A., Oyeleye, S. I., & Oboh, G. (2015) · Biochemistry Research International · doi:10.1155/2015/347673 · Cited by 86
Self-citationAgu, K. C., Eluehike, N., Ofeimun, R. O., Abile, D., Ideho, G., Ogedengbe, M. O., Onose, P. O., & Elekofehinti, O. O. (2019) · Clinical Phytoscience · doi:10.1186/s40816-019-0116-0 · Cited by 53
Metadata
- Authors
- Oboh, G., Ademiluyi, A. O., Akinyemi, A. J., Henle, T., Saliu, J. A., & Schwarzenbolz, U.
- Venue
- Journal of Functional Foods
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 4
- Issue
- 2
- Pages
- 450-458
- ISSN
- 1756-4646 (ISSN-L)
- OpenAlex
- W2030252394
- Cited by
- 250
- References
- 6
- FWCI
- 11.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Oboh, G., Ademiluyi, A. O., Akinyemi, A. J., Henle, T., Saliu, J. A., & Schwarzenbolz, U. (2012). Inhibitory effect of polyphenol-rich extracts of jute leaf (Corchorus olitorius) on key enzyme linked to type 2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting) in vitro. Journal of Functional Foods. https://doi.org/10.1016/j.jff.2012.02.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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