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Cited by 31Coconut Research and ApplicationsSepsis Diagnosis and TreatmentMedicinal plant effects and applications

Tender coconut water suppresses hepatic inflammation by activating AKT and JNK signaling pathways in an in vitro model of sepsis

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Lakshmanan, Jaganathan, Zhang, Baochun, Wright, Kalen, Motameni, Amierreza T., Jaganathan, Vaitheesh L., Schultz, David J., Klinge, Carolyn M., Harbrecht, Brian G.·2020·Journal of Functional Foods
DOI 10.1016/j.jff.2019.103637PMC PMC7449535
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Abstract

Tender coconut water (TCW) is a natural plant product rich in phytochemicals and protects against toxic liver injury. However, the mechanism by which TCW inhibits inflammation and tissue damage is unknown. We examined the effect of TCW on primary rat hepatocyte viability, cytokine-induced gene expression and proinflammatory signaling in an in vitro model of sepsis. We observed that TCW improved hepatocyte viability and protected hepatocytes against cytokine-mediated cell death. TCW suppressed IL-1β-mediated increases in Nos2, Tnf, and Il6 mRNA and increased heme oxygenase 1 (HMOX1) protein. TCW inhibited iNOS expression through activation of AKT and JNK pathways since inhibition of PI3K and JNK signaling reduced TCW’s effect on iNOS protein expression and activity. These results demonstrate that TCW reduces proinflammatory gene expression and hepatocyte injury produced by elevated inflammatory cytokines and nitric oxide production.

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Cited by

Sorted by citations

Authors
Lakshmanan, J., Zhang, B., Wright, K., Motameni, A. T., Jaganathan, V. L., Schultz, D. J., Klinge, C. M., & Harbrecht, B. G.
Affiliations
University of Louisville (US)
Corresponding author
Lakshmanan, Jaganathan
ORCID
Venue
Journal of Functional Foods
Publisher
Elsevier BV
Published
2020-01
Volume
64
Pages
103637
ISSN
1756-4646 (ISSN-L)
DOI
10.1016/j.jff.2019.103637
PMC
PMC7449535
OpenAlex
W2989297712
Cited by
31
References
4
Citations by year
2026: 4 · 2025: 5 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 1
FWCI
0.94
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Functional Foods (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases
Topics
  • Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal plant effects and applications
Keywords
tender coconut water, sepsis, liver inflammation, hepatocyte injury, Akt signaling, JNK signaling, PI3K signaling, inducible nitric oxide synthase, nitric oxide, heme oxygenase-1, IL-1β, cytokine-induced gene expression, hepatoprotection, natural plant products

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