Main nitric oxide (NO) hallmarks to relieve arsenic stress in higher plants
Abstract
Arsenic (As) is a toxic metalloid that adversely affects plant growth, and poses severe risks to human health. It induces disturbance to many physiological and metabolic pathways such as nutrient, water and redox imbalance, abnormal photosynthesis and ATP synthesis and loss of membrane integrity. Nitric oxide (NO) is a free radical molecule endogenously generated in plant cells which has signalling properties. Under As-stress, the endogenous NO metabolism is significantly affected in a clear connection with the metabolism of reactive oxygen species (ROS) triggering nitro-oxidative stress. However, the exogenous NO application provides beneficial effects under As-stress conditions which can relieve oxidative damages by stimulating the antioxidant systems, regulation of the expression of the transporter and other defence-related genes, modification of root cell wall composition or the biosynthesis of enriched sulfur compounds such phytochelatins (PCs). This review aims to provide up-to-date information on the key NO hallmarks to relieve As-stress in higher plants. Furthermore, it will be analyzed the diverse genetic engineering techniques to increase the endogenous NO content which could open new biotechnological applications, especially in crops under arsenic stress.
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Heavy metals are toxic and cause illnesses and diseases such as lung cancer and cancers of other respiratory organs, kidney and bladder, damage to the brain and reproductive organs, and heart and immune system disorders.
“Moreover, since they are toxic, they cause illnesses and diseases such as lung cancer and cancers of other respiratory organs, the kidney and bladder, damage to the brain and reproductive organs, and heart and immune system disorders (P.Ahmad et al., 2020;Ali et al., 2019;Bhat et al., 2021).”
From Adsorption of heavy metals on natural zeolites: A review (2023) · cites this paper as Bhat et al., 2021
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Adsorption of heavy metals on natural zeolites: A review
Velarde, L., Nabavi, M. S., Escalera, E., Antti, M.-L., & Akhtar, F. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.138508 · Cited by 491 · see citing works
“Moreover, since they are toxic, they cause illnesses and diseases such as lung cancer and cancers of other respiratory organs, the kidney and bladder, damage to the brain and reproductive organs, and heart and immune system disorders (P. Ahmad et al., 2020; Ali et al., 2019; Bhat et al., 2021).”
- Authors
- Bhat, J. A., Ahmad, P., & Corpas, F. J.
- Affiliations
- Nanjing Agricultural University (CN)
- King Saud University (SA)
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Corpas, Francisco J.
- Venue
- Journal of Hazardous Materials
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 406
- Pages
- 124289
- ISSN
- 0304-3894 (ISSN-L)
- OpenAlex
- W3092931136
- Cited by
- 107
- References
- 227
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 20 · 2023: 30 · 2022: 23 · 2021: 18 · 2020: 1
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hazardous Materials (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- European Regional Development Fund
- Ministry of Economy and Competitiveness (PID2019-103924GB-I00)
- Plan Andaluz de Investigación, Desarrollo e Innovación (P18-FR-1359)
- Junta de Andalucía (BIO192)
- King Saud University (RG-1438-039)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Physical Sciences › Environmental Science › Environmental Chemistry › Arsenic contamination and mitigation
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- nitric oxide, arsenic stress, metalloid toxicity, higher plants, nitro-oxidative stress, reactive oxygen species, antioxidant defense, phytochelatins, sulfur metabolism, root cell wall, transporter gene expression, crop biotechnology
- MeSH terms
- Antioxidants, Arsenic, Humans, Nitric Oxide, Reactive Oxygen Species, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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