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Associations between vaping during pregnancy and perinatal outcomes: A systematic review and meta-analysis

Deprato, Andy, Garud, Arundhati, Azzolina, Danila, Murgia, Nicola, Davenport, Margie H., Kaul, Padma, Lacy, Paige, Moitra, Subhabrata·2025·Journal of Hazardous Materials
DOI 10.1016/j.jhazmat.2024.137028
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Abstract

Despite numerous studies linking prenatal vaping to adverse perinatal outcomes, a systematic assessment for critical comparison remains absent. To investigate these associations, we conducted a systematic search of studies assessing perinatal outcomes in mothers and/or neonates exposed to vaping during pregnancy compared to those in women without prenatal vaping exposure through MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Library, PROSPERO, and Google Scholar until July 5, 2024. We performed inverse-variance random-effects meta-analyses for maternal and neonatal outcomes of 23 studies with a total of 924,376 participants with 7552 reporting vaping-only use during pregnancy. Prenatal vaping was associated with 53 % higher odds of an adverse maternal outcome (OR: 1.53; 95 % CI: 1.27-1.85; I 2 = 80 %), particularly with decreased breastfeeding (OR: 0.53; 95 % CI: 0.38-0.72; I 2 = 45 %) and reduced prevalence of adequate prenatal care (OR: 0.69; 95 % CI: 0.56-0.86; I 2 = 82 %). Prenatal vaping was also associated with a similarly 53 % higher odds of an adverse neonatal outcome (OR: 1.53; 95 % CI: 1.34-1.76; I 2 = 45 %), such as low birth weight (OR: 1.56; 95 % CI: 1.28-1.93; I 2 : 15 %), preterm birth (OR: 1.49; 955 CI: 1.27-1.76; I 2 : 0 %), and small for gestational age (OR: 1.48; 955 CI: 1.16-1.89; I 2 : 70 %). This is the first comprehensive systematic review and meta-analysis demonstrating vaping during pregnancy as a risk factor for increased odds of both maternal and…

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Metadata

Authors
Deprato, A., Garud, A., Azzolina, D., Murgia, N., Davenport, M. H., Kaul, P., Lacy, P., & Moitra, S.
Venue
Journal of Hazardous Materials
Publisher
Elsevier BV
Published
2025-03
Volume
486
Pages
137028
ISSN
0304-3894
DOI
10.1016/j.jhazmat.2024.137028
Cited by
25
References
16
Language
en
Licence
Funders
  • Northern Alberta Clinical Trials and Research Centre
  • Canadian Lung Association
  • Institute of Circulatory and Respiratory Health

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