Cited by 314Liver Disease Diagnosis and TreatmentBirth, Development, and HealthDiet, Metabolism, and Disease

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Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice

Oben, Jude A., Mouralidarane, Angelina, Samuelsson, Anne-Maj, Matthews, Phillippa J., Morgan, Maelle L., Mckee, Chad, Soeda, Junpei, Fernandez-Twinn, Denise S., Martin-Gronert, Malgorzata S., Ozanne, Susan E., Sigala, Barbara, Novelli, Marco, Poston, Lucilla, Taylor, Paul D.·2010·Journal of Hepatology

DOI 10.1016/j.jhep.2009.12.042

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Abstract

Background & aims Obesity induced, non-alcoholic fatty liver disease (NAFLD), is now the major cause in affluent countries, of the spectrum of steatosis-to-cirrhosis. Obesity and NAFLD rates in reproductive age women, and adolescents, are rising worldwide. Our hypothesis was that maternal obesity and lactation transmit to the offspring a pre-disposition to dysmetabolism, obesity and NAFLD. Methods Female mice were fed standard or obesogenic chow, before, throughout pregnancy, and during lactation. The critical developmental period was studied by cross-fostering offspring of lean and obese dams. Offspring were then weaned onto standard chow and studied at 3months. Read-outs included markers of metabolic dysfunction, biochemical and histological indicators of NAFLD, induction of liver fibrogenesis, and activation of pro-fibrotic pathways. Mechanisms involved in programming a dysmetabolic and NAFLD phenotype were investigated by assaying breast milk components. Results Offspring of obese dams had a dysmetabolic, insulin resistant and NAFLD phenotype compared to offspring of lean dams. Offspring of lean dams that were suckled by obese dams showed an exaggerated dysmetabolic and NAFLD phenotype, with increased body weight, as well as increased levels of insulin, leptin, aspartate transaminase, interleukin-6, tumour necrosis factor-alpha, liver triglycerides, steatosis, hepatic fibrogenesis, renal norepinephrine, and liver alpha1-D plus beta1-adrenoceptors, indicative of sympathetic nervous system activation. Obese dams also had raised breast milk leptin levels compared to lean dams. Conclusions Maternal obesity programs development of a dysmetabolic and NAFLD phenotype, which is critically dependent on the early postnatal period and possibly involving alteration of hypothalamic appetite nuclei signalling by maternal breast milk and neonatal adipose tissue derived, leptin.

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Nonalcoholic Fatty Liver Disease
Angulo, P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011775 · Cited by 5,228
The fetal and infant origins of adult disease.
Barker, D. J. (1990) · BMJ · doi:10.1136/bmj.301.6761.1111 · Cited by 2,768
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
Gual, P., Le Marchand-Brustel, Y., & Tanti, J.-F. (2005) · Biochimie · doi:10.1016/j.biochi.2004.10.019 · Cited by 912 · cited 1×
“Reduced liver IRS expression and hyper-phosphorylation of IRS serine residues are key factors in the development of insulin resistance and type 2 diabetes [17,18].”
Background
Minireview: Leptin and Development of Hypothalamic Feeding Circuits
Bouret, S. G., & Simerly, R. B. (2004) · Endocrinology · doi:10.1210/en.2004-0231 · Cited by 210
Norepinephrine Is Required for Leptin Effects on Gene Expression in Brown and White Adipose Tissue1
Commins, S. P., Marsh, D. J., Thomas, S. A., Watson, P. M., Padgett, M. A., Palmiter, R., & Gettys, T. W. (1999) · Endocrinology · doi:10.1210/endo.140.10.7043 · Cited by 107

Flagged first, then by citations

Show all 0 references

Research works printed but not linked: 35

Targher, 2007, Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients, Diabetes Care, 30, 1212, 10.2337/dc06-2247 · DOI
Hedley, 2004, Prevalence of overweight and obesity among US children, adolescents, and adults, 1999–2002, JAMA, 291, 2847, 10.1001/jama.291.23.2847 · DOI
Barker, 1995, The fetal and infant origins of disease, Eur J Clin Invest, 25, 457, 10.1111/j.1365-2362.1995.tb01730.x · DOI
Ravelli, 1999, Obesity at the age of 50 y in men and women exposed to famine prenatally, Am J Clin Nutr, 70, 811, 10.1093/ajcn/70.5.811 · DOI
Yajnik, 2000, Interactions of perturbations in intrauterine growth and growth during childhood on the risk of adult-onset disease, Proc Nutr Soc, 59, 257, 10.1017/S0029665100000288 · DOI
Catalano, 2003, Obesity and pregnancy–the propagation of a viscous cycle?, J Clin Endocrinol Metab, 88, 3505, 10.1210/jc.2003-031046 · DOI
Catalano, 2003, Gestational diabetes and insulin resistance: role in short- and long-term implications for mother and fetus, J Nutr, 133, 1674S, 10.1093/jn/133.5.1674S · DOI
Oken, 2003, Fetal origins of obesity, Obes Res, 11, 496, 10.1038/oby.2003.69 · DOI
Day, 1998, Steatohepatitis: a tale of two “hits”?, Gastroenterology, 114, 842, 10.1016/S0016-5085(98)70599-2 · DOI · Paper page
Oben, 2003, Norepinephrine induces hepatic fibrogenesis in leptin deficient ob/ob mice, Biochem Biophys Res Commun, 308, 284, 10.1016/S0006-291X(03)01360-3 · DOI
Oben, 2004, Hepatic fibrogenesis requires sympathetic neurotransmitters, Gut, 53, 438, 10.1136/gut.2003.026658 · DOI
Folch, 1957, A simple method for the isolation and purification of total lipides from animal tissues, J Biol Chem, 226, 497, 10.1016/S0021-9258(18)64849-5 · DOI · Paper page
Kleiner, 2005, Design and validation of a histological scoring system for nonalcoholic fatty liver disease, Hepatology, 41, 1313, 10.1002/hep.20701 · DOI · Paper page
Samuelsson, 2008, Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance. a novel murine model of developmental programming, Hypertension, 51, 383, 10.1161/HYPERTENSIONAHA.107.101477 · DOI · Paper page
Zick, 2004, Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistance, Biochem Soc Trans, 32, 812, 10.1042/BST0320812 · DOI
Watanabe, 2008, Liver diseases and metabolic syndrome, J Gastroenterol, 43, 509, 10.1007/s00535-008-2193-6 · DOI
Browning, 2004, Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity, Hepatology, 40, 1387, 10.1002/hep.20466 · DOI · Paper page
McCurdy, 2009, Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates, Journal of Clinical Investigation, 119, 323
Khan, 2004, Predictive adaptive responses to maternal high-fat diet prevent endothelial dysfunction but not hypertension in adult rat offspring, Circulation, 110, 1097, 10.1161/01.CIR.0000139843.05436.A0 · DOI
Sanchez, 2005, Leptin orally supplied to neonate rats is directly uptaken by the immature stomach and may regulate short-term feeding, Endocrinology, 146, 2575, 10.1210/en.2005-0112 · DOI
Pico, 2007, Role of leptin present in maternal milk in the control of energy balance during the post-natal period, Genes Nutr, 2, 139, 10.1007/s12263-007-0038-1 · DOI
Kirk, 2009, Maternal obesity induced by diet in rats permanently influences central processes regulating food intake in offspring, PLoS One, 4, e5870, 10.1371/journal.pone.0005870 · DOI
Bouret, 2004, Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice, J Neurosci, 24, 2797, 10.1523/JNEUROSCI.5369-03.2004 · DOI
Ahima, 2000, Postnatal regulation of hypothalamic neuropeptide expression by leptin: implications for energy balance and body weight regulation, Regul Pept, 92, 1, 10.1016/S0167-0115(00)00142-7 · DOI
Franke, 2005, ‘Programming’ of orexigenic and anorexigenic hypothalamic neurons in offspring of treated and untreated diabetic mother rats, Brain Res, 1031, 276, 10.1016/j.brainres.2004.11.006 · DOI
McMillen, 2008, Developmental origins of adult health and disease: the role of periconceptional and foetal nutrition, Basic Clin Pharmacol Toxicol, 102, 82, 10.1111/j.1742-7843.2007.00188.x · DOI
Plagemann, 2008, A matter of insulin: developmental programming of body weight regulation, J Matern Fetal Neonatal Med, 21, 143, 10.1080/14767050801929869 · DOI
Tilg, 2000, Cytokines in Alcoholic and Nonalcoholic Steatohepatitis, N Engl J Med, 343, 1467, 10.1056/NEJM200011163432007 · DOI
Nieto-Vazquez, 2008, Insulin resistance associated to obesity: the link TNF-alpha, Arch Physiol Biochem, 114, 183, 10.1080/13813450802181047 · DOI
Diehl, 2003, Insulin resistance syndrome and nonalcoholic fatty liver disease, Endocr Pract, 9, 93, 10.4158/EP.9.S2.93 · DOI
Saxena, 2002, Leptin in hepatic fibrosis: Evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice, Hepatology, 35, 762, 10.1053/jhep.2002.32029 · DOI · Paper page
Vickers, 2001, Dysregulation of the adipoinsular axis – a mechanism for the pathogenesis of hyperleptinemia and adipogenic diabetes induced by fetal programming, J Endocrinol, 170, 323, 10.1677/joe.0.1700323 · DOI
Bachem, 1989, The role of thrombocytes in liver fibrogenesis: effects of platelet lysate and thrombocyte-derived growth factors on the mitogenic activity and glycosaminoglycan synthesis of cultured rat liver fat storing cells, J Clin Chem Clin Biochem, 27, 555
Hirose, 2007, Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis, Hepatology, 45, 1375, 10.1002/hep.21638 · DOI
Barshop, 2008, Review article: epidemiology, pathogenesis and potential treatments of paediatric non-alcoholic fatty liver disease, Aliment Pharmacol Ther, 28, 13, 10.1111/j.1365-2036.2008.03703.x · DOI

Sorted by citations

Items 201–273 of 273

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Qian, Y., Sun, H. X., Xiao, H., Ma, M., Xiao, X., & Qu, Q. (2017) · Biomedical Reports · doi:10.3892/br.2017.878 · Cited by 15
“Maternal over-nutrition has been reported to be associated with elevated triglyceride levels, increased inflammatory markers and fatty livers in offspring (33).”
Developmental Origins of Nonalcoholic Fatty Liver Disease (NAFLD).
Itoh, H., & Kanayama, N. (2018) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-10-5526-3_4 · Cited by 10
Epigenetic Mechanisms of Maternal Obesity Effects on the Descendants
Cordero, P., Li, J., Temple, J., Nguyen, V., & Oben, J. A. (2016) · Springer eBooks · doi:10.1007/978-1-4939-6386-7_16 · Cited by 7
Self-citation
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Shrestha, A., Dellett, S. K., Yang, J., Sharma, U., & Ramalingam, L. (2023) · Nutrients · doi:10.3390/nu15245038 · Cited by 9
“The basis of parental obesity’s inﬂuence on offspring NAFLD development draws upon the understanding of maternal genetic and gestational factors because these inﬂuences have been investigated at length [10–16].”
Background
Evidence from 3-month-old infants shows that a combination of postnatal feeding and exposures in utero shape lipid metabolism
Furse, S., Snowden, S., Olga, L., Prentice, P., Ong, K., Hughes, I., Acerini, C., Dunger, D., & Koulman, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-50693-0 · Cited by 9
Prenatal metformin treatment improves ovarian function in offspring of obese rats
Álvarez, D., Ceballo, K., Olguín, S., Martínez-Pinto, J., Maliqueo, M. A., Fernandois, D., Sotomayor‐Zárate, R., & Cruz, G. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0352 · Cited by 9
The adipokine C1q TNF related protein 3 (CTRP3) is elevated in the breast milk of obese mothers
Kwon, M. R., Cress, E., Clark, W., Alamian, A., Lu, Y., & Peterson, J. (2018) · PeerJ · doi:10.7717/peerj.4472 · Cited by 9
“Further, experimental evidence in animal models (offspring of normal weight dams that were suckled by obese dams) demonstrated an exaggerated metabolic phenotype in adulthood (Oben et al., 2010).”
Background
Maternal Weight Management to Prevent the Developmental Programming of MAFLD in Offspring of Obese Mothers
Purcell, A. R., & Glastras, S. J. (2023) · Nutrients · doi:10.3390/nu15092155 · Cited by 9
“A high maternal pre-pregnancy BMI is also associated with known constituents of metabolic dysfunction in the offspring, namely increased insulin resistance which can exacerbate adipose tissue lipolysis and increase the hepatic uptake of lipid species [13,14,29,31].”
Background
Pregnancy and Metabolic-Associated Fatty Liver Disease
Mandato, C., Panera, N., & Alisi, A. (2023) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2023.02.005 · Cited by 9
Developmental modeling of hepatogenesis using obese iPSCs-hepatocyte differentiation uncovers pathological features
Varghese, D. S., Alawathugoda, T. T., Sheikh, M. A., Challagandla, A. K., Emerald, B. S., & Ansari, S. A. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05125-9 · Cited by 12
Fish oil supplementation during adolescence attenuates metabolic programming of perinatal maternal high-fat diet in adult offspring
Souza, A. F. P., Souza, L. L., Oliveira, L. S. D., Cordeiro, A., Souza, E., Kluck, G. E. G., Atella, G. C., Trevenzoli, I. H., & Pazos-Moura, C. C. (2019) · British Journal Of Nutrition · doi:10.1017/s0007114519000771 · Cited by 14
Maternal Physical Activity and Sex Impact Markers of Hepatic Mitochondrial Health
Cunningham, R. P., Moore, M. P., Meers, G., Ruegsegger, G. N., Booth, F. W., & Rector, R. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001675 · Cited by 8
Cord Blood Adipokines and Lipids and Adolescent Nonalcoholic Fatty Liver Disease
Simpson, J., Smith, A. D. A. C., Fraser, A., Sattar, N., Callaway, M., Lindsay, R., Lawlor, D., & Nelson, S. (2016) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2016-2604 · Cited by 8
“Consistent with this, cross-suckling experimental data suggest that exposure to maternal obesity only via lactation more aggressively programs a dysmetabolic and NAFLD phenotype than intrauterine exposure (8).”
Background
Practical management of the increasing burden of non-alcoholic fatty liver disease
Mouralidarane, A., Lin, C., Suleyman, N. M., Soeda, J., & Oben, J. A. (2010) · Frontline Gastroenterology · doi:10.1136/fg.2009.000935 · Cited by 8
“It has, moreover, been recently shown that maternal obesity by offspring programming during neonatal and immediate perinatal development can increase susceptibility to NAFLD in adulthood.”
BackgroundSelf-citation
Reprogramming offspring liver health: maternal indole supplementation as a preventive strategy against MASLD
Mandala, A., Undi, R. B., Janssen, R. C., Sugino, K. Y., Zhao, W., Nelson, B. N., Teague, A. M., Patil, N. Y., Berry, K. A. Z., Varshney, R., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.106098 · Cited by 7
Maternal high-fat diet affects the contents of eggs and causes abnormal development in the medaka fish
Inoue, Y., Fukushima, M., Hirasawa, G., Furukawa, F., Takeda, H., & Umatani, C. (2023) · bioRxiv · doi:10.1101/2023.10.10.561638 · Cited by 7
Maternal obesity alters the placental transcriptome in a fetal sex-dependent manner
Kelly, A. C., Chan, J., Powell, T. L., Cox, L. A., Jansson, T., & Rosario, F. J. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1178533 · Cited by 10
“It is notable that offspring in this model are programmed for future diseases (Samuelsson et al., 2008; Kirk et al., 2009; Oben et al., 2010; Samuelsson et al., 2010; Reynolds et al., 2013; Samuelsson et al., 2013; Taylor et al., 2014), demonstrating that the link between maternal obesity and offspring cardiometabolic…”
Background
Adult mice offspring of obese mothers supplemented with melatonin show lessened liver steatosis, inflammation, oxidative stress, and endoplasmic reticulum stress
Ajackson, M., Nagagata, B. A., Marcondes‐de‐Castro, I. A., Mandarim‐de‐Lacerda, C. A., & Águila, M. B. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121253 · Cited by 8
Pre-Weaning Exposure to Maternal High-Fat Diet Is a Critical Developmental Window for Programming the Metabolic System of Offspring in Mice
Yang, H., Chen, N., Fan, L., Lin, X., Liu, J., You, Y., Zhong, Y., Chen, Y., Li, J., & Xiao, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.816107 · Cited by 7
“Other studies have shown that maternal HFD programs a NAFLD phenotype, which is critically dependent on the neonatal period (21).”
Background
Parental SIRT1 Overexpression Attenuate Metabolic Disorders Due to Maternal High-Fat Feeding
Nguyen, L. T., Saad, S., Chen, H., & Pollock, C. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197342 · Cited by 7
“Maternal obesity has been associated with the development of non-alcoholic fatty liver disease (NAFLD) in offspring, characterised by an increase in lipid droplet accumulation and inflammation in the liver [21,22], which is also what we found in the current study.”
Background
Molecular characterization of Wdr13 knockout female mice uteri: a model for human endometrial hyperplasia
Singh, S., Pavuluri, S., Lakshmi, B. J., Biswa, B. B., Venkatachalam, B., Tripura, C., & Kumar, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-70773-w · Cited by 7
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Hori, H., Umezawa, M., Uchiyama, M., Niki, R., Yanagita, S., & Takeda, K. (2014) · Journal of Perinatal Medicine · doi:10.1515/jpm-2013-0091 · Cited by 7
“Additionally, fat accumulation and insulin resistance were increased in the liver of offspring from dams fed a high-fat diet [37].”
Background
Maternal Weight Intervention in the Perinatal Period Improves Liver Health in the Offspring of Mothers with Obesity
Purcell, A. R., Rodrigo, N., Cao, Q., Joseph, O., Gill, A. J., Saad, S., Pollock, C., & Glastras, S. (2023) · Nutrients · doi:10.3390/nu16010109 · Cited by 6
“A promising outcome emergent from this study is that all modes of weight intervention, whether they involve dietary modifications before or during pregnancy or pre-pregnancy liraglutide administration, are effective at ameliorating adverse liver effects of maternal obesity in the offspring.”
Background
MATERNAL OBESOGENIC DIET ATTENUATES MICROBIOME DEPENDENT OFFSPRING WEANING REACTION WITH WORSENING OF STEATOTIC LIVER DISEASE.
Lian, V., Hinrichs, H., Young, M., Faerber, A., Özler, O., Xie, Y., Ballentine, S., Tarr, P., Davidson, N. O., & Thompson, M. D. (2023) · American Journal of Pathology · doi:10.1016/j.ajpath.2023.11.006 · Cited by 6
“6 e 9,12,16,18 Most studies have shown increased steatosis and in ﬂ ammation in the liver of offspring exposed to a SLD-inducing diet after MODE, 6,7,9,19 and some studies have shown worsened ﬁ brosis.”
Background
Dietary lipid droplet structure in postnatal life improves hepatic energy and lipid metabolism in a mouse model for postnatal programming
Jeleník, T., Kodde, A., Pesta, D. H., Phielix, E., Oosting, A., Rohbeck, E., Dewidar, B., Mastrototaro, L., Trenkamp, S., Keijer, J., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106193 · Cited by 7
Seeing the fetus from a DOHaD perspective: discussion paper from the advanced imaging techniques of DOHaD applications workshop held at the 2019 DOHaD World Congress
Morrison, J., Ayonrinde, O., Care, A. S., Clarke, G. D., Darby, J., David, A., Dean, J., Hooper, S., Kitchen, M., Macgowan, C., et al. (2020) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174420000884 · Cited by 6
Mitochondrial dysfunction characterises the multigenerational effects of maternal obesity on MASLD
Heldens, A., Antwi, M., Onghena, L., Meese, T., Gansemans, Y., Smet, J., Dupont, E., Verhelst, X., Raevens, S., van Vlierberghe, H., et al. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101404 · Cited by 5
“11,28 These results are consistent with our data, as we found that offspring exposed to (multigenerational) maternal WD feeding already developed hepatic steatosis and in ﬂ ammation at weaning age.”
Antiapoptic Activity of Cinnamon on Some Organs of 18 Days Rat Fetuses of Diabetic Mother
El‐Beeh, M. E., Fouda, Y., El-Badry, D. A., & El‐Sayyad, H. I. (2019) · Biosciences Biotechnology Research Asia · doi:10.13005/bbra/2779 · Cited by 8
“Neonates of mothers fed on a hiigh fat diet during pregnancy and lactation altered hepatic structure and function parallel with Non-Alcoholic Steatohepatitis (Oben et al., 2010; Dudley et al., 2011).”
Background
Maternal coconut oil intake on lactation programs for endocannabinoid system dysfunction in adult offspring
OLIVEIRA, E. B. D., Quitete, F. T., Bernardino, D. N., Guarda, D. S., Caramez, F. A. H., Soares, P. N., Peixoto, T. C., Rodrigues, V. S. T., Trevenzoli, I. H., de Moura, E. G., et al. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.05.002 · Cited by 7
Aerobic exercise training performed by parents reduces mice offspring adiposity
Romero, P. V. D. S., Guariglia, D. A., da Rocha, F. F., Picoli, C. C., Gilio, G. R., Fabricio, G. S., Mathias, P. C. D. F., de Moraes, S. M. F., & Peres, S. B. (2017) · Journal of Sports Sciences · doi:10.1080/02640414.2017.1405474 · Cited by 6
“Increased levels of circulating fatty acids, in the long-term, are related to hyperinsulinemia, insulin resistance and consequent inhibition of glucose uptake, a clinical condition found primarily in obese individuals (Oben et al., 2010; Saltiel & Kahn, 2001).”
Background
Maternal obesogenic diet induces endometrial hyperplasia, an early hallmark of endometrial cancer, in a diethylstilbestrol mouse model
Owuor, T. O., Reid, M., Reschke, L. D., Hagemann, I. S., Greco, S., Modi, Z., & Moley, K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0186390 · Cited by 5
Adipose Tissue Uncoupling Protein 1 Levels and Function are Increased in a Mouse Model of Developmental Obesity Induced by Maternal Exposure to High Fat Diet
Prewit, E., Porter, C., Rosa, M. L., Bhattarai, N., Yin, H.-Z., Gamble, P., Kechichian, T., & Sidossis, L. (2018) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174418000107 · Cited by 5
Folate Treatment Partially Reverses Gestational Low Protein Diet Induced Glucose Intolerance and the Magnitude of Reversal is Age and Sex Dependent
Blesson, C., Schutt, A., Mathew, P. R., Tanchico, D., Balakrishnan, M. P., Yallampalli, U., & Yallampalli, C. (2017) · Nutrition (Burbank, Los Angeles County, Calif.) · doi:10.1016/j.nut.2017.10.014 · Cited by 5
The Microbiome: What Will the Future Hold?
Monsour, H., & Quigley, E. (2016) · Seminars in liver disease (Print) · doi:10.1055/s-0036-1594009 · Cited by 5
Furthering the understanding of maternal obesity in NAFLD
Vos, M. B. (2013) · Hepatology · doi:10.1002/hep.26389 · Cited by 5
“All of this was associated with increased tumor necrosis factor alpha (TNF-a), decreased hepatic mitochondrial electron transport chain enzyme complex activity, and liver inflammation in the offspring simply from high-fat diet during gestation.(2,5,6) The roles for maternal and child dietary composition, and the poten…”
Background
Developmental Origins of Insulin Resistance and Type 2 Diabetes
Ozanne, S. E., & Siddle, K. (2011) · Wiley eBooks · doi:10.1002/9781444347319.ch4 · Cited by 3
Self-citation
Critical Importance of the Perinatal Period in the Development of Obesity
Baker, P. R., & Friedman, J. E. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1203-2_4
Protective effect of antioxidants on cardiac function in adult offspring exposed to prenatal overnutrition
Zhang, J., Cao, L., Wang, W., Huo, Y., Zheng, Y., Wu, F., & Gui, Y. (2022) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174422000095 · Cited by 4
Pathophysiology and clinical management of non-alcoholic fatty liver disease
Mouralidarane, A., Oben, J., & Soeda, J. (2011) · Medicine · doi:10.1016/j.mpmed.2011.07.014 · Cited by 4
Self-citation
The Impact of Maternal Obesity and Weight Loss During the Periconceptional Period on Offspring Metabolism
Nicholas, L. M., & McMillen, I. C. (2016) · Springer eBooks · doi:10.1007/978-1-4939-6386-7_7 · Cited by 3
Metabolic imprinting due to small litter size mitigates insulin resistance through the interscapular brown adipose tissue activation in a high-sucrose diet model
de Deus, I. J., de Abreu, A. R. D., Fagundes, M. M. D. A., Silva, J. L., Breguez, G. S., Silva, Â. A., Siqueira, É. C. D. S. O., Carneiro, C. M., Costa, D. C., Paula-Gomes, S., et al. (2025) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174425100123 · Cited by 3
“3,4 Nutrition plays a crucial role in shaping the epigenome throughout critical windows of development, such as the neonatal period, where it can influence gene expression and long-term metabolic outcomes.”
Randomised controlled trial of exercise training during lactation on breast milk composition in breastfeeding people with overweight/obesity: a study protocol for the MILKSHAKE trial
Moholdt, T., Ashby, E. R., Tømmerdal, K. H., Lemoine, M. C. C., Holm, R. L., Sætrom, P., Iversen, A., Ravi, A., Simpson, M. R., & Giskeødegård, G. (2023) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2023-001751 · Cited by 3
“15 17 Maternal physical exercise, however, has received very little attention with respect to breast milk composition.”
Background
Glucocorticoids contribute to metabolic and liver impairments induced by lactation overnutrition in male adult rats
de Souza, C. F., Stopa, L., Martins, A. B., Wunderlich, A., Lopes, G. M., Silva, F. D. F., Komino, A. C. M., Zaia, D., Zaia, C. T., Lima, F. B., et al. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1161582 · Cited by 3
“Animals with childhood obesity present metabolic liver dysfunctions such as TG accumulation (Oben et al., 2010), increased circulating free fatty acids, hyperinsulinemia, impairment of the insulin signaling pathway in the liver and skeletal muscle, in addition to a higher concentration of circulating glucocorticoids (…”
Background
Trimester two gestational exposure to bisphenol A and adherence to mediterranean diet are associated with adolescent offspring oxidative stress and metabolic syndrome risk in a sex-specific manner
Zamora, A. N., Marchlewicz, E. H., Téllez‐Rojo, M. M., Burant, C., Cantoral, A., Song, P. X. ‐., Mercado, A., Dolinoy, D. C., & Peterson, K. E. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.961082 · Cited by 2
Maternal sitagliptin treatment attenuates offspring glucose metabolism and intestinal proinflammatory cytokines IL-6 and TNF-α expression in male rats
Zhang, Q., Xiao, X., Zheng, J., Li, M., Yu, M., Ping, F., Wang, T., & Wang, X.-J. (2020) · PeerJ · doi:10.7717/peerj.10310 · Cited by 3
Fatty acid intake during perinatal periods
de la Garza, A. L., Alba, C. T.-D., Cárdenas-Pérez, R. E., Camacho‐Morales, A., Gutiérrez-López, M., & Castro, H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813862-5.00006-2 · Cited by 2
The Implications of Maternal Obesity on Offspring Physiology and Behavior in the Nonhuman Primate
Sullivan, E. L., & Kievit, P. (2016) · Springer eBooks · doi:10.1007/978-1-4939-6386-7_10 · Cited by 4
TGFβ in the obese liver mediates conversion of NK cells to a less cytotoxic ILC1-like phenotype
Cuff, A. O., Sillito, F., Dertschnig, S., Hall, A., Luong, T. V., Chakraverty, R., & Male, V. (2019) · doi:10.1101/576538 · Cited by 101
The Developmental Mechanisms of Obesity by Maternal Obesity
Nguyen, L., Pollock, C., & Saad, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-35358-2_14 · Cited by 2
Metabolic Syndrome: From Human Organ Disease to Fetal Programming
Neto-Ferreira, R. (2014) · Journal of Metabolic Syndrome · doi:10.4172/2167-0943.1000133 · Cited by 1
“Excessive maternal nutrition also causes adverse hepatic remodeling as obesity and IR act as cornerstones in NAFLD development [163].”
Background
Maternal Western-style Diet Promotes Immune Tolerance and Liver Sinusoidal Endothelial Cell Dysfunction in Nonhuman Primate Juvenile Offspring LiverPreprint
Nash, M. J., Nelson, B. N., McGuckin, M. M., Janssen, R. C., Jones, K. L., Al‐Juboori, S. I., Dobrinskikh, E., Kievit, P., Aagaard, K. M., McCurdy, C. E., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.06.697995 · Cited by 1
“9).”
Maternal obesity during pregnancy disrupts iron homeostasis and promotes fetal hypoxia in the mouse
Córdova-Casanova, A., Inzani, I., Hufnagel, A., Giussani, D. A., Fernandez‐Twinn, D. S., & Ozanne, S. E. (2025) · The Journal of Physiology · doi:10.1113/jp288635 · Cited by 2
Self-citation
Cross-generational effects of dietary sea buckthorn on non-alcoholic fatty liver disease in offspring of obese female mice
Zhang, W.-P., Shi, Y., Wang, Y., Liu, X., Yan, J.-C., Chen, H.-R., & Zhao, J. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106398 · Cited by 1
Polyphenol rich fruit attenuates genomic instability, modulates inflammation and cell cycle progression of offspring from fatty acid intake maternal.
Argentato, P. P., Pisani, L., de Rosso, V. D., Soares, G. R., Silva, M. J. D., Vilegas, W., & Ribeiro, D. (2019) · Pathophysiology · doi:10.1016/j.pathophys.2019.11.002 · Cited by 1
Developmental programming of non‐alcoholic fatty liver disease
Li, J.-W., Cordero, P., & Oben, J. (2016) · doi:10.1002/9781118924938.ch26 · Cited by 1
Self-citation
Applying developmental programming to clinical obstetrics: my ward round
Painter, R. C. (2015) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174415001099 · Cited by 1
Current Models of Fatty Liver Disease; New Insights, Therapeutic Targets and Interventions
Jonscher, K. R., & Bruce, K. D. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-12668-1_3 · Cited by 1
Maternal obesity imprints methylation marks in oocytes to drive intergenerational metabolic dysfunction
Han, L., Wu, Y., Li, J., Chen, Y., Li, L., Wang, T., Chen, M., Wang, S., Li, C., Ding, G., et al. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01617-6
The impact of high fat diet on global protein abundance and fractional synthetic rate in liver and mammary gland of peak lactation ICR mice
Beckett, L. M., Lichti, N. I., Teeple, K. M., Thirumalaikumar, V. P., Hernandez, L. L., Rajwa, B. P., Jannasch, A., Han-Hallett, Y., & Casey, T. (2026) · PLoS ONE · doi:10.1371/journal.pone.0346148
Accelerated early weight gain of neonatal puppies from overweight bitches compared to lean dams in spite of similar milk macronutrient composition
McCarter, S. J., Werre, S., Power, M. L., & Balogh, O. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1747221
Desarrollo temprano de hígado graso no alcohólico por exposición fetal a obesidad gestacional. Revisión de tema
Rivera-Aguirre, J. (2023) · Revista Médicas UIS · doi:10.18273/revmed.v36n3-2023001
Effect of a Diet-Induced Obesity on the Progeny Response in a Murine Model
Paffetti, M. G., Cárcamo, J. G., Azócar-Aedo, L., & Parra, A. (2023) · Nutrients · doi:10.3390/nu15234970
Concise review: Breastfeeding, lactation, and NAFLD. An updated view of cross-generational disease transmission and prevention
Lonardo, A., & Suzuki, A. (2023) · Metabolism and Target Organ Damage · doi:10.20517/mtod.2023.17 · Cited by 10
Sympathetic blockage attenuates fasting-induced hepatic steatosis
Zheng, L., Gong, L., Cai, X., Lu, S., Zhou, Y., Duan, Z., Fang, W. Y., & Li, G. (2022) · Neuroreport · doi:10.1097/wnr.0000000000001844 · Cited by 1
“…et al., 2020; Bruinstroop et al., 2014; Edinburgh and Frampton, 2020; Guarino et al., 2017; Yi et al., 2010) or indirectly modulate hepatic steatosis through governing the release of adipokines(Miyamoto et al., 2012; Oben et al., 2010; Wang et al., 2020; Warne et al., 2011; Zeng et al., 2015).”
Background
Nonalcoholic Fatty Liver Disease
Fitzpatrick, E. (2015) · Springer eBooks · doi:10.1007/978-3-319-17169-2_66 · Cited by 3
The Effect of Maternal Pre-pregnancy Body Mass Index on Very Low Birth Weight Infants
Baek, K. S., Jin, B. K., Jeon, J.-H., & Heo, J. S. (2018) · Neonatal Medicine · doi:10.5385/nm.2018.25.3.118
Developmental Programming of Nonalcoholic Fatty Liver Disease (NAFLD)
Bruce, K. D., & Cagampang, F. R. A. (2016) · Springer eBooks · doi:10.1007/978-1-4939-6386-7_12 · Cited by 1
Obesidad en el embarazo: razones para volver a preocuparse de la nutrición materna
Jofré, M., & Ebensperger, E. O. (2012) · Medwave · doi:10.5867/medwave.2012.07.5459
Maternal diet and nutritional status and risk of obesity in the child: the role of epigenetic mechanisms
Suter, M., & Aagaard-Tillery, K. M. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511782466.014
The epidemiology and significance of nonalcoholic fatty liver disease in adolescents
Ayonrinde, O. (2018) · doi:10.4225/23/5b35a837b3980
Fetal Origins of Adult Disease
Friedman, J., & Baker, P. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-35214-7.00015-9 · Cited by 1
Mechanisms Linking Maternal Obesity to Offspring Metabolic Health
Dearden, L., & Ozanne, S. E. (2016) · Springer eBooks · doi:10.1007/978-1-4939-6386-7_8
Self-citation
Fetal Metabolic Programming
Aiken, C. (2016) · Springer eBooks · doi:10.1007/978-3-319-11251-0_14

Authors: Oben, J. A., Mouralidarane, A., Samuelsson, A.-M., Matthews, P. J., Morgan, M. L., Mckee, C., Soeda, J., Fernandez-Twinn, D. S., Martin-Gronert, M. S., Ozanne, S. E., Sigala, B., Novelli, M., Poston, L., & Taylor, P. D.
Affiliations: St Thomas' Hospital (GB)
King's College London (GB)
The Royal Free Hospital (GB)
University of Cambridge (GB)
University College London (GB)
Corresponding author: Oben, Jude A.
ORCID: Oben, Jude A.
Samuelsson, Anne-Maj
Soeda, Junpei
Ozanne, Susan E.
Novelli, Marco
Poston, Lucilla
Taylor, Paul D.
Venue: Journal of Hepatology
Publisher: Elsevier BV
Published: 2010-06
Volume: 52
Issue: 6
Pages: 913-920
ISSN: 0168-8278 (ISSN-L)
DOI: 10.1016/j.jhep.2009.12.042
OpenAlex: W2034714209
Cited by: 314
References: 0
Citations by year: 2026: 4 · 2025: 12 · 2024: 8 · 2023: 28 · 2022: 24 · 2021: 10 · 2020: 21 · 2019: 31 · 2018: 22 · 2017: 20 · 2016: 28 · 2015: 21 · 2014: 27 · 2013: 25 · 2012: 14
FWCI: 13.26
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Hepatology (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: British Heart Foundation (FS/10/003/28163, FS/09/029/27902)
Biotechnology and Biological Sciences Research Council (BB/F015364/1)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: maternal obesity, non-alcoholic fatty liver disease, developmental programming, lactation, cross-fostering, insulin resistance, leptin, breast milk, liver fibrosis, sympathetic nervous system, adrenergic receptors, leptin resistance, dysmetabolism, offspring phenotype, obesogenic diet
MeSH terms: Actins, Adipose Tissue, Animals, Collagen, Fatty Liver, Female, Lactation, Mice, Inbred C57BL, Milk, Obesity, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Tumor Necrosis Factor-alpha, Signal Transduction, Interleukin-6, Gene Expression, Receptors, Adrenergic, alpha-1, Leptin, Collagen Type I, Metabolic Syndrome, Mice

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Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice

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