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Cited by 278

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Modest alcohol consumption is associated with decreased prevalence of steatohepatitis in patients with non-alcoholic fatty liver disease (NAFLD)

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Dunn, Winston, Sanyal, Arun J., Brunt, Elizabeth M., Unalp-Arida, Aynur, Donohue, Michael, McCullough, Arthur J., Schwimmer, Jeffrey B.·2012·Journal of Hepatology
DOI 10.1016/j.jhep.2012.03.024
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Abstract

Background & Aims Nonalcoholic fatty liver disease (NAFLD) is a cardiovascular risk factor. Although modest alcohol consumption may reduce the risk for cardiovascular mortality, whether patients with NAFLD should be allowed modest alcohol consumption remains an important unaddressed issue. We aimed to evaluate the association between modest alcohol drinking and nonalcoholic steatohepatitis(NASH), among subjects with NAFLD. Methods In a Cross-sectional analysis of adult participants in the NIH NASH Clinical Research Network, only modest or non-drinkers were included: participants identified as 1) drinking > 20gm/day, 2) binge drinkers, or 3) non-drinkers with previous alcohol consumption were excluded. The odds of having a histological diagnosis of NASH and other histological features of NAFLD were analyzed using multiple ordinal logistic regression. Results The analysis included 251 lifetime non-drinkers and 331 modest drinkers. Modest drinkers compared to nondrinkers had lower odds of having a diagnosis of NASH (Summary odds ratio 0.56, 95%CI 0.39–0.84, p=0.002). The odds of NASH decreased as the frequency of alcohol consumption increased within the range of modest consumption. Modest drinkers also had significantly lower odds for fibrosis (OR 0.56 95%CI 0.41–0.77) and ballooning hepatocellular injury (OR 0.66 95%CI 0.48–0.92) than lifetime non-drinkers. Conclusions In a large, well-characterized population with biopsy-proven NAFLD, modest alcohol consumption was associated with lesser degree of severity as determined by lower odds of the key features that comprise a diagnosis of steatohepatitis, as well as fibrosis. These findings demonstrate the need for prospective studies and a coordinated consensus on alcohol consumption recommendations in NAFLD.

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Metadata

Authors
Dunn, W., Sanyal, A. J., Brunt, E. M., Unalp-Arida, A., Donohue, M., McCullough, A. J., & Schwimmer, J. B.
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
2012-08
Volume
57
Issue
2
Pages
384-391
ISSN
0168-8278 (ISSN-L)
DOI
10.1016/j.jhep.2012.03.024
OpenAlex
W2149813265
Cited by
278
References
5
FWCI
13.36
Type
journal article
Language
en
Open access
green

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