Modest alcohol consumption decreases the risk of non-alcoholic fatty liver disease: a meta-analysis of 43 175 individuals
Open accessAbstract
Epidemiological studies suggested that the prevalence and the disease severity of non-alcoholic fatty liver disease (NAFLD) are lower for people who drink modest amounts of alcohol than those who are abstainers. Nevertheless, the evidence is still inconclusive because some recently published studies1 showed that modest alcohol consumption (MAC) increases hepatic fat without increasing the risk of advanced fibrosis.
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Earlier cohort and cross-sectional studies on individuals with non-cirrhotic MASLD showed no effect or even protective effects of low-moderate alcohol consumption on overall mortality, MASLD and steatohepatitis.
“Earlier cohort and cross-sectional studies on individuals with non-cirrhotic MASLD showed no effect or even protective effects of lowmoderate alcohol consumption on overall mortality, MASLD and steatohepatitis.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [89]
The sections on NAFLD and NASH prevalence report associations between modest alcohol consumption and lower odds of NAFLD and NASH. The paper does not report overall mortality, and its NASH section calls for future prospective cohort studies rather than presenting cohort evidence on disease progression. The claim therefore extends beyond the outcomes and study designs supported by this source. (LLM, conf=0.89)
Experimental — accuracy not yet measuredIn people with non-cirrhotic MASLD the evidence for low or moderate alcohol consumption is conflicting.
“In people with non-cirrhotic MASLD the evidence for low or moderate alcohol consumption is con fl icting.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [89]
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Cites
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- Authors
- Sookoian, S., Castaño, G. O., & Pirola, C. J.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Research Council in Health, Ciudad Autónoma de Buenos Aires, Argentina
- Corresponding author
- Sookoian, Silvia
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2013-09-11
- Volume
- 63
- Issue
- 3
- Pages
- 530-532
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2098629785
- Cited by
- 158
- References
- 10
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 21 · 2023: 9 · 2022: 22 · 2021: 15 · 2020: 16 · 2019: 10 · 2018: 9 · 2017: 11 · 2016: 12 · 2015: 9 · 2014: 8
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- Universidad de Buenos Aires
- Agencia Nacional de Promoción Científica y Tecnológica (PICT-2008-1521)
- Secretaría de Ciencia y Técnica, Universidad de Buenos Aires
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- non-alcoholic fatty liver disease, moderate drinking, alcohol consumption, liver fat, liver fibrosis, disease risk
- MeSH terms
- Adult, Alcohol Drinking, Fatty Liver, Female, Humans, Male, Middle Aged, Risk, Models, Statistical, Odds Ratio, Non-alcoholic Fatty Liver Disease
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