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Cited by 646

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Acute-on chronic liver failure

Open access
Jalan, Rajiv, Gines, Pere, Olson, Jody C, Mookerjee, Rajeshwar P, Moreau, Richard, Garcia-Tsao, Guadalupe, Arroyo, Vicente, Kamath, Patrick S·2012·Journal of Hepatology

Abstract

Acute-on-chronic liver failure (ACLF) is an increasingly recognised entity encompassing an acute deterioration of liver function in patients with cirrhosis, which is usually associated with a precipitating event and results in the failure of one or more organs and high short term mortality. Prospective data to define this is lacking but there is a large body of circumstantial evidence suggesting that this condition is a distinct clinical entity. From the pathophysiologic perspective, altered host response to injury and infection play important roles in its development. This review focuses upon the current understanding of this syndrome from the clinical, prognostic and pathophysiologic perspectives and indicates potential biomarkers and therapeutic targets for intervention.

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Registry

Crossref · 10.1016/j.jhep.2012.06.026

Cites

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Metadata

Authors
Jalan, R., Gines, P., Olson, J. C., Mookerjee, R. P., Moreau, R., Garcia-Tsao, G., Arroyo, V., & Kamath, P. S.
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
2012-12
Volume
57
Issue
6
Pages
1336-1348
ISSN
0168-8278 (ISSN-L)
OpenAlex
W2086721895
Cited by
646
References
10
FWCI
31.25
Type
journal article
Language
en
Open access
hybrid

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.