Autologous Bone Marrow Mononuclear Cell Transplantation in Patients with Decompensated Alcoholic Liver Disease: A Randomized Controlled Trial
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OBJECTIVE: Impaired liver regeneration is associated with a poor outcome in patients with decompensated alcoholic liver disease (ALD). We assessed whether autologous bone marrow mononuclear cell transplantation (BMMCT) improved liver function in decompensated ALD. DESIGN: 58 patients (mean age 54 yrs; mean MELD score 19, all with cirrhosis, 81% with alcoholic steatohepatitis at baseline liver biopsy) were randomized early after hospital admission to standard medical therapy (SMT) alone (n = 30), including steroids in patients with a Maddrey's score ≥32, or combined with G-CSF injections and autologous BMMCT into the hepatic artery (n = 28). Bone marrow cells were harvested, isolated and reinfused the same day. The primary endpoint was a ≥3 points decrease in the MELD score at 3 months, corresponding to a clinically relevant improvement in liver function. Liver biopsy was repeated at week 4 to assess changes in Ki67+/CK7+ hepatic progenitor cells (HPC) compartment. RESULTS: Both study groups were comparable at baseline. After 3 months, 2 and 4 patients died in the BMMCT and SMT groups, respectively. Adverse events were equally distributed between groups. Moderate alcohol relapse occurred in 31% of patients. The MELD score improved in parallel in both groups during follow-up with 18 patients (64%) from the BMMCT group and 18 patients (53%) from the SMT group reaching the primary endpoint (p = 0.43 (OR 1.6, CI 0.49-5.4) in an intention to treat analysis. Comparing liver biopsy at 4 weeks to baseline, steatosis improved (p<0.001), and proliferating HPC tended to decrease in both groups (-35 and -33%, respectively). CONCLUSION: Autologous BMMCT, compared to SMT is a safe procedure but did not result in an expanded HPC compartment or improved liver function. These data suggest either insufficient regenerative stimulation after BMMCT or resistance to liver regenerative drive in patients with decompensated alcoholic cirrhosis. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN83972743.
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In decompensated alcoholic cirrhosis, the combination of bone marrow mononuclear cells with standard medical therapy did not show superiority over standard medical therapy alone.
“Another clinical trial in decompensated alcoholic cirrhosis (DAC) also indicated that the combination of BM-MNCs with standard medical therapy (SMT) did not show superiority over SMT alone [53].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [53]
G-CSF mobilization failed to stimulate liver progenitor cell expansion or promote liver regeneration.
“Furthermore, this approach, which included G-CSF mobilization, failed to stimulate LPC expansion or promote liver regeneration [53].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [53]
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791 · see citing works
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I. L., & Grompe, M. (2000) · Nature Medicine · doi:10.1038/81326 · Cited by 2,314 · see citing works
Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets
Gao, B., & Bataller, R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.09.002 · Cited by 1,963 · see citing works
The model for end-stage liver disease (MELD)
Kamath, P. S., & Kim, R. W. (2007) · Hepatology · doi:10.1002/hep.21563 · Cited by 1,674 · see citing works
Roskams, T., Theise, N. D., Balabaud, C. P., Bhagat, G., Bhathal, P. S., Bioulac‐Sage, P., Brunt, E. M., Crawford, J. M., Crosby, H. A., Desmet, V. J., et al. (2004) · Hepatology · doi:10.1002/hep.20130 · Cited by 729 · see citing works
Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells
Fausto, N. (2004) · Hepatology · doi:10.1002/hep.20214 · Cited by 720 · see citing works
EASL Clinical Practical Guidelines: Management of Alcoholic Liver Disease
European Association for the Study of the Liver (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.04.004 · Cited by 720 · see citing works
Acute-on chronic liver failure
Jalan, R., Ginès, P., Olson, J. C., Mookerjee, R. P., Moreau, R., García–Tsao, G., Arroyo, V., & Kamath, P. S. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.06.026 · Cited by 672 · see citing works
Stem Cells and Liver Regeneration
Duncan, A. W., Dorrell, C., & Grompe, M. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.05.044 · Cited by 547 · see citing works
Terai, S., Ishikawa, T., Ômori, K., Aoyama, K., Marumoto, Y., Urata, Y., Yokoyama, Y., Uchida, K., Yamasaki, T., Fujii, Y., et al. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0542 · Cited by 491 · see citing works
Braun, L., Mead, J. E., Panzica, M. A., Mikumo, R., Bell, G. I., & Fausto, N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.5.1539 · Cited by 479 · see citing works
Garg, V., Garg, H., Khan, A., Trehanpati, N., Kumar, A., Sharma, B. C., Sakhuja, P., & Sarin, S. K. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.11.027 · Cited by 391 · see citing works
A Randomized Trial of Prednisolone in Patients with Severe Alcoholic Hepatitis
Ramond, M.-J., Poynard, T., RUEFF, B., Mathurin, P., Theodore, C., Chaput, J., & Benhamou, J. (1992) · New England Journal of Medicine · doi:10.1056/nejm199202203260802 · Cited by 386 · see citing works
Peng, L., Xie, D., Lin, B., Liu, J., Zhu, H., Xie, C., Zheng, Y., & Gao, Z. (2011) · Hepatology · doi:10.1002/hep.24434 · Cited by 366 · see citing works
Mathurin, P., Mendenhall, C. L., Carithers, R. L., Ramond, M.-J., Maddrey, W. C., Garstide, P., RUEFF, B., Naveau, S., Chaput, J., & Poynard, T. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00289-6 · Cited by 350 · see citing works
Gordon, M. Y., Levičar, N., Pai, M., Bachellier, P., Dimarakis, I., Al-Allaf, F. A., M’Hamdi, H., Thalji, T., Welsh, J. P., Marley, S. B., et al. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0629 · Cited by 275 · see citing works
Sancho‐Bru, P., Altamirano, J., Rodrigo‐Torres, D., Coll, M., Millán, C., Lozano, J. J., Miquel, R., Arroyo, V., Caballería, J., Ginès, P., et al. (2012) · Hepatology · doi:10.1002/hep.25614 · Cited by 225 · see citing works
Srikureja, W., Kyulo, N. L., Runyon, B. A., & Hu, K. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2004.12.022 · Cited by 223 · see citing works
Spahr, L., Lambert, J., Rubbia‐Brandt, L., Chalandon, Y., Frossard, J., Giostra, E., & Hadengue, A. (2008) · Hepatology · doi:10.1002/hep.22317 · Cited by 221 · see citing works
Self-citationPai, M., Zacharoulis, D., Milićević, M., Helmy, S., Jiao, L. R., Levičar, N., Tait, P., Scott, M., Marley, S. B., Jestice, K., et al. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.01993.x · Cited by 218 · see citing works
Critical Review of Clinical Trials of Bone Marrow Stem Cells in Liver Disease
Houlihan, D. D., & Newsome, P. N. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.05.040 · Cited by 189 · see citing works
Clinical profile and predictors of mortality in patients of acute-on-chronic liver failure
Garg, H., Kumar, A., Garg, V., Sharma, P., Sharma, B. C., & Sarin, S. K. (2011) · Digestive and Liver Disease · doi:10.1016/j.dld.2011.08.029 · Cited by 187 · see citing works
Amer, M.-E. M., El-Sayed, S. Z., El-Kheir, W. A., Gabr, H., Gomaa, A. A., El-Noomani, N., & Hegazy, M. (2011) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e3283488b00 · Cited by 180 · see citing works
Liver regeneration in acute severe liver impairment: a clinicopathological correlation study
Katoonizadeh, A., Nevens, F., Verslype, C., Pirenne, J., & Roskams, T. (2006) · Liver International · doi:10.1111/j.1478-3231.2006.01377.x · Cited by 171 · see citing works
Yip, W. W., & Burt, A. D. (2006) · Seminars in Diagnostic Pathology · doi:10.1053/j.semdp.2006.11.002 · Cited by 150 · see citing works
Piscaglia, A. C., Shupe, T. D., Oh, S., Gasbarrini, A., & Petersen, B. E. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.018 · Cited by 135 · see citing works
Lyra, A. C., Soares, M. B. P., da Silva, L. F. M., Braga, E. L., de Oliveira, S. A., Fortes, M. F., Silva, A. G. P., Brustolim, D., Genser, B., dos Santos, R. R., et al. (2009) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32832eb69a · Cited by 109 · see citing works
Jianping, C. H. E. N., Ishac, E. J. N., Dent, P., Kunos, G., & Gao, B. (1998) · Biochemical Journal · doi:10.1042/bj3340669 · Cited by 107 · see citing works
Pharmacological Relapse Prevention of Alcoholism: Clinical Predictors of Outcome
Kiefer, F., Helwig, H., Tarnaske, T., Otte, C., Jahn, H., & Wiedemann, K. (2005) · European Addiction Research · doi:10.1159/000083037 · Cited by 106 · see citing works
Farinati, F., Cardin, R., D’Errico, A., Maria, N. D., Naccarato, R., Cecchetto, A., & Grigioni, W. F. (1996) · Hepatology · doi:10.1002/hep.510230625 · Cited by 97 · see citing works
The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis
Kisseleva, T., & Brenner, D. A. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.09.021 · Cited by 93 · see citing works
Thenappan, A., Li, Y., Kitisin, K., Rashid, A., Shetty, K., Johnson, L. B., & Mishra, L. (2009) · Hepatology · doi:10.1002/hep.23449 · Cited by 92 · see citing works
Enhanced CD34 expression of sinusaid‐like vascular endothelial cells in hepatocellular carcinoma
Cui, S., Hano, H., Sakata, A., Harada, T., Liu, T., TAKAI, S., & Ushigomey, S. (1996) · Pathology International · doi:10.1111/j.1440-1827.1996.tb03544.x · Cited by 92 · see citing works
The management of alcoholic liver disease
Stewart, S. F., & Day, C. P. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00427-0 · Cited by 91 · see citing works
Spahr, L., Rubbia‐Brandt, L., Pugin, J., Giostra, E., Frossard, J., Borisch, B., & Hadengue, A. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00190-8 · Cited by 88 · see citing works
Self-citationBone marrow-derived stem cells in liver repair: 10 years down the line
Gilchrist, E. S., & Plevris, J. N. (2010) · Liver Transplantation · doi:10.1002/lt.21965 · Cited by 81 · see citing works
Bone marrow stem cells and liver regeneration
Almeida-Porada, G. D., Zanjani, E. D., & Porada, C. D. (2010) · Experimental Hematology · doi:10.1016/j.exphem.2010.04.007 · Cited by 75 · see citing works
Saito, T., Okumoto, K., Haga, H., Nishise, Y., Ishii, R., Sato, C., Watanabe, H., Okada, A., Ikeda, M., Togashi, H., et al. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0074 · Cited by 75 · see citing works
Ji, S.-Q., Chen, H., Wang, H.-X., Yan, H.-M., Pan, S.-P., & Xun, C.-Q. (2002) · Transplantation and Cellular Therapy · doi:10.1053/bbmt.2002.v8.pm12064363 · Cited by 55 · see citing works
Horiguchi, N., Ishac, E., & Gao, B. (2007) · Alcohol · doi:10.1016/j.alcohol.2007.04.008 · Cited by 51 · see citing works
Spahr, L., Rubbia‐Brandt, L., Genevay, M., Hadengue, A., & Giostra, E. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-115 · Cited by 50 · see citing works
Self-citationFujii, K., Ishimaru, F., Kozuka, T., Matsuo, K., Nakase, K., Kataoka, I., Tabayashi, T., Shinagawa, K., Ikeda, K., Harada, M., et al. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04745.x · Cited by 49 · see citing works
Bone Marrow Stem Cells Contribute to Alcohol Liver Fibrosis in Humans
Dalakas, E., Newsome, P. N., Boyle, S., Brown, R. R. H., Pryde, A., McCall, S., Hayes, P. C., Bickmore, W. A., Harrison, D. J., & Plevris, J. N. (2009) · Stem Cells and Development · doi:10.1089/scd.2009.0387 · Cited by 45 · see citing works
Management of Alcoholic Liver Disease
Lucey, M. R. (2009) · Clinics in Liver Disease · doi:10.1016/j.cld.2009.02.003 · Cited by 38 · see citing works
Fauser, A., & Messner, H. (1979) · Blood · doi:10.1182/blood.v54.6.1384.1384 · Cited by 33 · see citing works
Brunt, E. M., Walsh, S. N., Hayashi, P. H., LaBundy, J. L., & Bisceglie, A. M. D. (2007) · Liver International · doi:10.1111/j.1478-3231.2007.01470.x · Cited by 32 · see citing works
Jin, S., Meng, X., Sun, X., Han, M.-Z., Liu, B.-R., Wang, X., Sun, L., Huang, Q., Zhao, R., Ban, X., et al. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-009-1117-5 · Cited by 30 · see citing works
Hillan, K. J., Logan, M. C., Ferrier, R. K., Bird, G. L. A., Bennett, G. L., McKay, I. C., & MacSween, R. N. M. (1996) · Journal of Hepatology · doi:10.1016/s0168-8278(96)80157-7 · Cited by 20 · see citing works
A Fluorescent Microsphere-Based Method for Assay of Multiple Analytes in Plasma
Bernhard, O. K., Mathias, R. A., Barnes, T. W., & Simpson, R. J. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-068-3_12 · Cited by 14 · see citing works
Management of Alcoholic Liver Disease
Jeewan, R., Ds, A., Dixon, T., & Yr, P. (2011) · Cited by 2 · see citing works
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Seitz, H. K., Bataller, R., Cortez-Pinto, H., Gao, B., Gual, A., Lackner, C., Mathurin, P., Mueller, S., Szabo, G., & Tsukamoto, H. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0014-7 · Cited by 1,271 · see citing works
Stem cell-based therapy for human diseases
Hoang, D. M., Pham, P. T., Bach, T. Q., Ngo, A. T. L., Nguyen, Q. T., Phan, T. T. K., Nguyen, G. H., Le, P. T. T., Hoang, V. T., Forsyth, N. R., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01134-4 · Cited by 1,074 · see citing works
EASL Clinical Practice Guidelines: Management of alcohol-related liver disease
Thursz, M. R., Gual, A., Lackner, C., Mathurin, P., Moreno, C., Spahr, L., Sterneck, M. R., & Cortez‐Pinto, H. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.018 · Cited by 953 · see citing works
Self-citationGranulocyte Colony-Stimulating Factor in Severe Alcoholic Hepatitis: A Randomized Pilot Study
Singh, V., Sharma, A. K., Narasimhan, L. R., Bhalla, A., Sharma, N., & Sharma, R. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.154 · Cited by 228 · see citing works
Hematopoietic Stem Cells and Their Roles in Tissue Regeneration
Lee, J. Y., & Hong, S.-H. (2020) · International Journal of Stem Cells · doi:10.15283/ijsc19127 · Cited by 165 · see citing works
Newsome, P. N., Fox, R., King, A. L., Barton, D., Than, N.-N., Moore, J., Corbett, C., Townsend, S., Thomas, J., Guo, K., et al. (2018) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(17)30326-6 · Cited by 162 · see citing works
Microencapsulated human mesenchymal stem cells decrease liver fibrosis in mice
Meier, R. P. H., Mahou, R., Morel, P., Meyer, J., Montanari, E., Muller, Y. D., Christofilopoulos, P., Wandrey, C., Gonelle-Gispert, C., & Bühler, L. H. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2014.10.030 · Cited by 153 · see citing works
Meier, R. P. H., Müller, Y. D., Morel, P., Gonelle‐Gispert, C., & Bühler, L. H. (2013) · Stem Cell Research · doi:10.1016/j.scr.2013.08.011 · Cited by 153 · see citing works
Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics
Ma, X., Huang, T., Chen, X., Li, Q., Liao, M., Fu, L., Huang, J., Yuan, K., Wang, Z., & Zeng, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02104-8 · Cited by 133 · see citing works
Kedarisetty, C. K., Anand, L., Bhardwaj, A., Bhadoria, A. S., Kumar, G., Vyas, A. K., David, P., Trehanpati, N., Rastogi, A., Bihari, C., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.02.054 · Cited by 133 · see citing works
Hepatic cell proliferation plays a pivotal role in the prognosis of alcoholic hepatitis
Lanthier, N., Rubbia‐Brandt, L., Lin-Marq, N., Clément, S., Frossard, J., Goossens, N., Hadengue, A., & Spahr, L. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.04.003 · Cited by 73 · see citing works
Self-citationCellular Therapy for Liver Disease
Huebert, R. C., & Rakela, J. L. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.10.023 · Cited by 71 · see citing works
Treatment of Severe Alcoholic Hepatitis
Thursz, M. R., & Morgan, T. R. M. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.074 · Cited by 70 · see citing works
Bihari, C., Anand, L., Rooge, S. B., Kumar, D., Saxena, P., Shubham, S., Sukriti, S., Trehanpati, N., Kumar, G., Pamecha, V., et al. (2016) · Hepatology · doi:10.1002/hep.28754 · Cited by 69 · see citing works
Iron Administration before Stem Cell Harvest Enables MR Imaging Tracking after Transplantation
Khurana, A., Chapelin, F., Beck, G., Lenkov, O. D., Donig, J., Nejadnik, H., Messing, S., Derugin, N., Chan, R. C., Gaur, A., et al. (2013) · Radiology · doi:10.1148/radiol.13130858 · Cited by 68 · see citing works
Systematic review: the effects of autologous stem cell therapy for patients with liver disease
Moore, J. K., Stutchfield, B. M., & Forbes, S. J. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12645 · Cited by 66 · see citing works
Zhang, J., Zhou, S., Zhou, Y. F., Feng, F., Wang, Q., Zhu, X., Ai, H., Huang, X., & Zhang, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114670 · Cited by 63 · see citing works
Role of microRNAs in Alcohol-Induced Multi-Organ Injury
Natarajan, S. K., Pachunka, J., & Mott, J. L. (2015) · Biomolecules · doi:10.3390/biom5043309 · Cited by 63 · see citing works
Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine
Giancotti, A., Monti, M., Nevi, L., Safarikia, S., D’Ambrosio, V., Brunelli, R., Pajno, C., Corno, S., Donato, V. D., Musella, A., et al. (2019) · Cells · doi:10.3390/cells8080914 · Cited by 60 · see citing works
The hematopoietic system in the context of regenerative medicine
Porada, C. D., Atala, A., & Almeida-Porada, G. D. (2015) · Methods · doi:10.1016/j.ymeth.2015.08.015 · Cited by 59 · see citing works
Mohamadnejad, M., Vosough, M., Moossavi, S., Nikfam, S., Mardpour, S., Akhlaghpoor, S., Ashrafi, M., Azimian, V., Jarughi, N., Hosseini, S.-E., et al. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0004 · Cited by 53 · see citing works
Zhou, G., Jiang, Y., Sun, L., & Zhu, Z. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01935-w · Cited by 53 · see citing works
Lanthier, N., Lin-Marq, N., Rubbia‐Brandt, L., Clément, S., Goossens, N., & Spahr, L. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0541-2 · Cited by 52 · see citing works
Self-citationEthical development of stem-cell-based interventions
MacPherson, A., & Kimmelman, J. (2019) · Nature Medicine · doi:10.1038/s41591-019-0511-6 · Cited by 47 · see citing works
Endothelial cell fitness dictates the source of regenerating liver vasculature
Singhal, M., Liu, X., Inverso, D., Jiang, K., Dai, J., He, H., Bartels, S., Li, W., Pari, A. A. A., Gengenbacher, N., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180008 · Cited by 42 · see citing works
Brennan, P., Macmillan, M. T., Manship, T. A., Moroni, F., Glover, A., Graham, C., Semple, S. I. K., Morris, D. M., Fraser, A. R., Pass, C., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-053190 · Cited by 41 · see citing works
Acute-on-chronic Liver Failure
Sarin, S. K., & Choudhury, A. K. (2016) · Current Gastroenterology Reports · doi:10.1007/s11894-016-0535-8 · Cited by 38 · see citing works
Severe alcoholic hepatitis: current perspectives
Philips, C. A., Augustine, P., Yerol, P. K., Rajesh, S., & Mahadevan, P. (2019) · Hepatic Medicine Evidence and Research · doi:10.2147/hmer.s197933 · Cited by 39 · see citing works
Xue, R., Meng, Q., Dong, J., Li, J., Yao, Q., Zhu, Y., & Yu, H. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1464-0 · Cited by 38 · see citing works
Qi, X., Guo, X., & Su, C. (2014) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x09666141112114011 · Cited by 34 · see citing works
King, A., Barton, D., Beard, H., Than, N. N., Moore, J. K., Corbett, C. J., Thomas, J. A., Guo, K., Guha, I. N., Hollyman, D., et al. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-007700 · Cited by 31 · see citing works
Cruz, F. F., Borg, Z. D., Goodwin, M., Coffey, A. L., Wagner, D. E., Rocco, P. R. M., & Weiss, D. J. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0141 · Cited by 31 · see citing works
Scaffold-free 3D culture systems for stem cell-based tissue regeneration
Liu, K.-C., Chen, Y.-C., Hsieh, C.-F., Wang, M., Zhong, M.-X., & Cheng, N. (2024) · APL Bioengineering · doi:10.1063/5.0225807 · Cited by 34 · see citing works
Effect of Autologous Bone Marrow Stem Cell Therapy in Patients with Liver Cirrhosis: A Meta-analysis
Wu, C., Wang, D., Cai, Y., Luo, A., & Sun, H. (2019) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2019.00008 · Cited by 30 · see citing works
Testino, G., Vignoli, T., Patussi, V., Scafato, E., & Caputo, F. (2019) · Digestive and Liver Disease · doi:10.1016/j.dld.2019.09.017 · Cited by 28 · see citing works
Treatment of severe alcoholic hepatitis: past, present and future
Lanthier, N., & Stärkel, P. (2017) · European Journal of Clinical Investigation · doi:10.1111/eci.12767 · Cited by 28 · see citing works
Self-citationLiver regeneration and alcoholic liver disease
Lv, Y., So, K., & Xiao, J. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.02.168 · Cited by 25 · see citing works
Molecular mechanisms of stem cell therapy in alcoholic liver disease
Levine, P., McDaniel, K. M., Francis, H., Kennedy, L. L., Alpini, G. D., & Meng, F. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.11.015 · Cited by 26 · see citing works
Cell transplantation-based regenerative medicine in liver diseases
Cardinale, V., Lanthier, N., Baptista, P. M., Carpino, G., Carnevale, G., Orlando, G., Angelico, R., Manzia, T. M., Schuppan, D., Pinzani, M., et al. (2023) · Stem Cell Reports · doi:10.1016/j.stemcr.2023.06.005 · Cited by 27 · see citing works
Self-citationNakamura, T., Torimura, T., Iwamoto, H., Kurogi, J., Inoue, H., Hori, Y., Sumie, S., Fukushima, N., Sakata, M., Koga, H., et al. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12622 · Cited by 24 · see citing works
Haemopoietic stem cell therapy in cirrhosis: the end of the story?
Lanthier, N. (2017) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(17)30359-x · Cited by 23 · see citing works
Self-citationHan, J., Lee, C., Hur, J., & Jung, Y. (2022) · Cells · doi:10.3390/cells12010022 · Cited by 21 · see citing works
Gustot, T. (2014) · Liver International · doi:10.1111/liv.12356 · Cited by 21 · see citing works
Mills, D. R., Mao, Q., Chu, S., Girard, K. F., Kraus, M., Padbury, J. F., & Paepe, M. E. D. (2017) · Experimental Lung Research · doi:10.1080/01902148.2017.1300713 · Cited by 20 · see citing works
Hepatic Regeneration in Cirrhosis
Jindal, A., Jagdish, R. K., & Kumar, A. (2021) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2021.08.029 · Cited by 20 · see citing works
Nguyen, T. L., Nguyen, H. P., Ngo, D. M., Ha, T. H. T., Mai, K. A., Bui, T. H., Nguyen, P. V., Pham, L. H., Hoang, D. M., & Cao, A. D. T. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02762-x · Cited by 19 · see citing works
Liver Regeneration by Hematopoietic Stem Cells: Have We Reached the End of the Road?
Siapati, E. K., Roubelakis, M. G., & Vassilopoulos, G. (2022) · Cells · doi:10.3390/cells11152312 · Cited by 19 · see citing works
Concise review: Bone marrow autotransplants for liver disease?
Behbahan, I. S., Keating, A., & Gale, R. P. (2013) · Stem Cells · doi:10.1002/stem.1510 · Cited by 17 · see citing works
Xue, R., Meng, Q., Li, J., Wu, J., Yao, Q., Yu, H., & Zhu, Y. (2018) · Translational research · doi:10.1016/j.trsl.2018.05.006 · Cited by 17 · see citing works
Ma, H., Shi, X., Yuan, X., & Ding, Y. (2016) · PubMed · doi:10.5604/16652681.1193723 · Cited by 17 · see citing works
Distinct EpCAM-Positive Stem Cell Niches Are Engaged in Chronic and Neoplastic Liver Diseases
Safarikia, S., Carpino, G., Overi, D., Cardinale, V., Venere, R., Franchitto, A., Onori, P., Alvaro, D., & Gaudio, E. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00479 · Cited by 16 · see citing works
Magdaleno, F., Ge, X., Fey, H., Lu, Y., Gaskell, H., Blajszczak, C. C., Aloman, C., Fiel, M. I., & Nieto, N. (2017) · Hepatology Communications · doi:10.1002/hep4.1116 · Cited by 16 · see citing works
Liver regeneration as treatment target for severe alcoholic hepatitis
Virović-Jukić, L., Ljubas, D., Stojsavljević, S., Ljubičić, N., Kanižaj, T. F., Mikolašević, I., & Grgurević, I. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i32.4557 · Cited by 15 · see citing works
Mesenchymal Stem Cell Transplantation in Liver Diseases
Nevens, F., & der Merwe, V. (2022) · Seminars in Liver Disease · doi:10.1055/s-0042-1755328 · Cited by 15 · see citing works
Autologous bone marrow transplantation in decompensated liver: Systematic review and meta-analysis
Prasoon, P. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i28.8697 · Cited by 15 · see citing works
Atewologun, F. A., Okesanya, O. J., Okon, I. I., Kayode, H. H., Ukoaka, B. M., Olaleke, N. O., Ogaya, J. B., Okikiola, L. A., Manirambona, E., & Lucero‐Prisno, D. E. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03864-4 · Cited by 12 · see citing works
Rayia, D. M. A., Ashour, D. S., Safia, H. S. A., Ghafar, M. T. A., Amer, R. S., & Saad, A. E. (2022) · Pathogens and Global Health · doi:10.1080/20477724.2022.2064795 · Cited by 12 · see citing works
Ex vivo expansion of circulating CD34+ cells enhances the regenerative effect on rat liver cirrhosis
Nakamura, T., Koga, H., Iwamoto, H., Tsutsumi, V., Imamura, Y., Naitou, M., Masuda, A., Ikezono, Y., Abe, M., Wada, F., et al. (2016) · Molecular Therapy — Methods & Clinical Development · doi:10.1038/mtm.2016.25 · Cited by 11 · see citing works
Insights into the Role of Granulocyte Colony-Stimulating Factor in Severe Alcoholic Hepatitis
Kedarisetty, C. K., Kumar, A., & Sarin, S. K. (2021) · Seminars in Liver Disease · doi:10.1055/s-0040-1719177 · Cited by 12 · see citing works
Novel Therapeutic Approaches in Treatment of Acute-on-Chronic Liver Failure
Saeidinejad, M., Shabrawi, A. E., Sriphoosanaphan, S., Andreola, F., Mehta, G., Agarwal, B., & Jalan, R. (2023) · Seminars in Liver Disease · doi:10.1055/s-0043-1776773 · Cited by 12 · see citing works
Immunological basis of stem cell therapy in liver diseases
Cui, L., Shi, Y., Han, Y., & Fan, D. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.930665 · Cited by 11 · see citing works
Philips, C. A., Augustine, P., Ahamed, R., Rajesh, S. K., George, T., Valiathan, G. C., & John, S. K. (2019) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2019.00034 · Cited by 10 · see citing works
Exploring the Most Promising Stem Cell Therapy in Liver Failure: A Systematic Review
Pawitan, J. A. (2019) · Stem Cells International · doi:10.1155/2019/2782548 · Cited by 10 · see citing works
Giancotti, A., D’Ambrosio, V., Corno, S., Pajno, C., Carpino, G., Amato, G., Vena, F., Mondo, A., Spiniello, L., Monti, M., et al. (2022) · Cytotherapy · doi:10.1016/j.jcyt.2021.10.012 · Cited by 10 · see citing works
Hernandez, J. C., Yeh, D., Marh, J., Choi, H. Y., Kim, J., Chopra, S., Ding, L., Thornton, M. E., Grubbs, B. H., Makowka, L., et al. (2022) · Hepatology Communications · doi:10.1002/hep4.1924 · Cited by 10 · see citing works
Cell transplantation as a non-invasive strategy for treating liver fibrosis
Matsumoto, T., Takami, T., & Sakaida, I. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2016.1134313 · Cited by 10 · see citing works
Wang, M.-F., Li, Y.-B., Gao, X., Zhang, H., Lin, S., & Zhu, Y. (2018) · World Journal of Stem Cells · doi:10.4252/wjsc.v10.i10.138 · Cited by 10 · see citing works
Yamaguchi, S., Kanetaka, K., Maruya, Y., Higashi, M., Kobayashi, S., Hashiguchi, K., Oohashi, F., Sakai, Y., Nakao, K., & Eguchi, S. (2021) · Surgical Endoscopy · doi:10.1007/s00464-021-08708-3 · Cited by 9 · see citing works
Preclinical-to-clinical innovations in stem cell therapies for liver regeneration
Chawla, S., & Das, A. (2022) · Current Research in Translational Medicine · doi:10.1016/j.retram.2022.103365 · Cited by 10 · see citing works
Copper-induced liver fibrosis affects the behavior of bone marrow cells in primary culture
Божков, А. И., Ivanov, E. G., Kuznetsova, Y. A., Ohiienko, S. L., & Bondar’, A. Y. (2017) · Frontiers in Biology · doi:10.1007/s11515-017-1458-y · Cited by 9 · see citing works
Stem cell therapy for hepatocellular carcinoma and end-stage liver disease
Abdellateif, M. S., & Zekri, A. N. (2023) · Journal of the Egyptian National Cancer Institute · doi:10.1186/s43046-023-00194-z · Cited by 8 · see citing works
Colli, A., Fraquelli, M., Prati, D., & Casazza, G. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013532.pub2 · Cited by 7 · see citing works
Cell therapy demonstrates promise for acute respiratory distress syndrome - but which cell is best?
Curley, G. F., & Laffey, J. G. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt179 · Cited by 6 · see citing works
Liver volume is a prognostic indicator for clinical outcome of patients with alcoholic hepatitis
Bréguet, R., Ronot, M., Goossens, N., Hansen, C., Giostra, E., Majno, P. E., Becker, C. D., Spahr, L., & Terraz, S. (2016) · Abdominal Radiology · doi:10.1007/s00261-016-0892-7 · Cited by 6 · see citing works
Self-citationSun, X., & Guo, S. (2022) · Cytotherapy · doi:10.1016/j.jcyt.2021.11.006 · Cited by 6 · see citing works
Cell Therapy for Liver Disease: From Promise to Reality
Khan, S., Khan, R. S., & Newsome, P. N. (2020) · Seminars in Liver Disease · doi:10.1055/s-0040-1717096 · Cited by 5 · see citing works
Liver Regeneration and Bioengineering
Baptista, P. M., Moran, E. C., Vyas, D., Shupe, T. D., & Söker, S. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-398523-1.00027-6 · Cited by 5 · see citing works
Wang, P., Li, Z., Ren, S., Li, J., Yang, J., Kong, G., Jiang, A., & Li, Z. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5091-7 · Cited by 5 · see citing works
Current Cell-Based Therapies in the Chronic Liver Diseases
Nishina, T., Hoshikawa, K. T., & Ueno, Y. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-4-431-56847-6_13 · Cited by 4 · see citing works
Autologous Bone Marrow–Derived Cells in the Treatment of Liver Disease Patients
AlAhmari, L. S., AlShenaifi, J. Y., AlAnazi, R. A., & Abdo, A. A. (2015) · Saudi Journal of Gastroenterology · doi:10.4103/1319-3767.151211 · Cited by 4 · see citing works
Liu, B., Cheng, M., Chen, X., Li, L., Si, Y., Wang, S., Wang, Y., & Shi, Y. (2020) · Bioscience Reports · doi:10.1042/bsr20191316 · Cited by 4 · see citing works
Ruan, M., Yin, Y., Ning, W., Zhang, B., Lin, H., Yu, H., Wang, X., Zou, D., Shao, X., Chen, J., et al. (2025) · Journal of Translational Internal Medicine · doi:10.1515/jtim-2025-0044 · Cited by 3 · see citing works
Hematopoiesis in Regenerative Medicine
Almeida-Porada, G. D., & Porada, C. D. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-410396-2.00028-1 · Cited by 3 · see citing works
Adult Stem Cell Therapy in Liver Cirrhosis Management: Current Practices and Future Perspectives
Gounder, S. S., Kodiappan, R., Chan, S. C., Veerakumarasivam, A., & Subramani, B. (2017) · International Journal of Stem cell Research & Therapy · doi:10.23937/2469-570x/1410049 · Cited by 3 · see citing works
Diagnosis and treatment of alcoholic hepatitis
Parker, R., & McCune, C. A. (2013) · Frontline Gastroenterology · doi:10.1136/flgastro-2013-100373 · Cited by 3 · see citing works
SPINK1, macrophages et cellules progénitrices du foie
Lanthier, N., & Spahr, L. (2016) · médecine/sciences · doi:10.1051/medsci/20163202005 · Cited by 3 · see citing works
Self-citationStem Cell Therapy in the Elderly with Liver Disease
Tomaszewski, M., & Wong, P. Y. N. (2019) · OBM Hepatology and Gastroenterology · doi:10.21926/obm.hg.1901013 · Cited by 3 · see citing works
Pan, X., Gao, T., & Wang, B. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01520-9 · Cited by 2 · see citing works
“Furthermore, this approach, which included G-CSF mobilization, failed to stimulate LPC expansion or promote liver regeneration [53].”
Ouyang, S., Ouyang, L., Li, Y., Ye, Y., & Ban, L. (2021) · The Turkish Journal of Gastroenterology · doi:10.5152/tjg.2021.19694 · Cited by 2 · see citing works
CD34+ Stem Cells and Regenerative Medicine
Henon, P. R. G., & Lahlil, R. (2021) · Springer eBooks · doi:10.1007/978-3-030-77052-5_2 · Cited by 1 · see citing works
Онищенко, Н. А., Nikolskaya, A. O., & Шагидулин, М. Ю. (2023) · Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia» · doi:10.25557/0031-2991.2023.03.109-123 · Cited by 1 · see citing works
Rutledge, S. M., & Brown, R. S. (2025) · Clinics in Liver Disease · doi:10.1016/j.cld.2025.09.005 · Cited by 1 · see citing works
Human stem cells for decompensated cirrhosis in adults
Aung, H. H., Naing, C. M., Ni, H., Aye, S. N., Htet, N. H., Kew, S. T., & Pavlov, C. S. (2025) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd015173.pub2 · Cited by 1 · see citing works
Hépatite alcoolique aiguë sévère
Nguyen-Khac, É., Dejour, V., Sarba, R., Yzet, T., Chatelain, D., Marcq, I., Chivot, C., Papillon, C. A., Attencourt, C., & Houchi, H. (2018) · La Presse Médicale · doi:10.1016/j.lpm.2018.05.013 · Cited by 1 · see citing works
Hépatite alcoolique aiguë sévère
Nguyen-Khac, É., Dejour, V., Sarba, R., Yzet, T., Turpin, J., Chatelain, D., Marcq, I., Chivot, C., Maizel, J., Papillon, C. A., et al. (2018) · Médecine Intensive Réanimation · doi:10.3166/rea-2018-0069 · Cited by 1 · see citing works
Alcoholic hepatitis: should we combine old drugs for better results?
Cabezas, J., & Bataller, R. A. (2016) · Hepatology International · doi:10.1007/s12072-016-9768-8 · Cited by 1 · see citing works
Novel Cell-Based Therapies in Hepatic Disorders
Felordi, M. S., Torabi, S., Shokoohian, B., Farzaneh, Z., Mohamadnejad, M., Malekzadeh, R., Baharvand, H., & Vosough, M. (2020) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1 · see citing works
Macrophage therapy and liver regeneration: Results and perspectives
Lanthier, N., & Spahr, L. (2025) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2025.102569 · Cited by 1 · see citing works
Self-citationCell Therapy for Liver Failure: A New Horizon
Riordan, N. H. (2015) · Springer eBooks · doi:10.1007/978-3-319-05543-5_25-1
iron administration before s tem cell harvest enables Mr imaging Tracking after
Khurana, A., Chapelin, F., Lenkov, O. D., Messing, S., Derugin, N., Chan, R. C., Gaur, A., Sennino, B., McDonald, D. M., Kempen, P. J., et al. (2013)
- Authors
- Spahr, L., Chalandon, Y., Terraz, S., Kindler, V., Rubbia-Brandt, L., Frossard, J.-L., Breguet, R., Lanthier, N., Farina, A., Passweg, J., Becker, C. D., & Hadengue, A.
- Affiliations
- University Hospital of Geneva (CH)
- Corresponding author
- Spahr, Laurent
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-01-14
- Volume
- 8
- Issue
- 1
- Pages
- e53719
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3544843
- OpenAlex
- W1985534351
- Cited by
- 118
- References
- 50
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 2 · 2023: 7 · 2022: 12 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 10 · 2017: 9 · 2016: 13 · 2015: 11 · 2014: 12 · 2013: 7
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- Digital Access to Libraries (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- American Association for the Study of Liver Diseases
- Louis-Jeantet Foundation
- Faculté de Médecine, Université de Genève
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- autologous bone marrow mononuclear cell transplantation, alcoholic cirrhosis, alcoholic steatohepatitis, liver regeneration, hepatic progenitor cells, MELD score, granulocyte colony-stimulating factor, liver function, alcohol relapse
- MeSH terms
- Adolescent, Adult, Aged, Female, Hepatic Artery, Humans, Liver, Liver Diseases, Alcoholic, Male, Middle Aged, Regeneration, Time Factors, Transplantation, Autologous, Biomarkers, Bone Marrow Transplantation, Cytokines, Recovery of Function, Hepatocytes, Stem Cell Transplantation, Cell Proliferation, Young Adult
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