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Cited by 234Liver Disease Diagnosis and TreatmentAdipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

The DOI matches its Crossref record; 33 of the 34 references it cites were found in a registry or an index.

Irisin is inversely associated with intrahepatic triglyceride contents in obese adults

Zhang, Hui-Jie, Zhang, Xian-Feng, Ma, Zhi-Min, Pan, Ling-Ling, Chen, Zheng, Han, Hai-Wei, Han, Cheng-Kun, Zhuang, Xiong-Jie, Lu, Yan, Li, Xue-Jun, Yang, Shu-Yu, Li, Xiao-Ying·2013·Journal of Hepatology
DOI 10.1016/j.jhep.2013.04.030
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Abstract

Background & aims Obesity is closely related to non-alcoholic fatty liver disease (NAFLD), which has become an important public health problem because of its high prevalence and association with metabolic syndromes. Irisin was recently identified as a novel peptide to improve obesity and glucose homeostasis, and considered to be therapeutic for human metabolic diseases. The aim of this study was to examine the association of serum irisin concentration and liver triglyceride contents in obese Chinese adults.Methods Serum irisin levels were measured and liver fat contents determined by (1)H MRS in 296 obese adults. Anthropometric parameters and blood biochemical indexes including liver enzymes, glucose, and lipid profiles were detected. The liver triglyceride contents of subjects were measured by (1)H MRS. The protein levels of irisin were determined by quantitative ELISA.Results We found that serum irisin levels were reduced in obese adults with NAFLD. By dividing the distribution of intrahepatic triglyceride (IHTG) contents into quartiles, serum irisin levels were reduced gradually with the increase of IHTG contents (p<0.01). Higher serum irisin levels were associated with preferable TG levels. Serum ALT and AST concentrations were inversely correlated with serum irisin levels. Multivariate linear regression analysis demonstrated that serum irisin levels were independently associated with liver fat (p<0.01). By logistic regression analysis, the odds ratio for higher IHTG contents was reduced by 12.4% per 1 SD increase in serum irisin concentrations after adjustment for multivariate metabolic factors [OR (95% CI); 0.876 (0.777-0.987)].Conclusions These results demonstrated that serum irisin concentrations were inversely associated with the triglyceride contents in the liver and liver enzymes in obese Chinese adults.

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Metadata

Authors
Zhang, H.-J., Zhang, X.-F., Ma, Z.-M., Pan, L.-L., Chen, Z., Han, H.-W., Han, C.-K., Zhuang, X.-J., Lu, Y., Li, X.-J., Yang, S.-Y., & Li, X.-Y.
Affiliations
  • Xiamen University (CN)
  • Shanghai Jiao Tong University (CN)
Corresponding author
Li, Xiao-Ying
ORCID
Chen, Zheng
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
2013-09
Volume
59
Issue
3
Pages
557-562
ISSN
0168-8278 (ISSN-L)
DOI
10.1016/j.jhep.2013.04.030
OpenAlex
W2101439943
Cited by
234
References
34
Citations by year
2026: 7 · 2025: 11 · 2024: 15 · 2023: 7 · 2022: 29 · 2021: 13 · 2020: 22 · 2019: 11 · 2018: 21 · 2017: 21 · 2016: 22 · 2015: 26 · 2014: 18 · 2013: 11
FWCI
18.70
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
irisin, intrahepatic triglyceride, non-alcoholic fatty liver disease, obesity, hepatic steatosis, liver fat, alanine aminotransferase, aspartate aminotransferase, serum biomarkers, Chinese adults
MeSH terms
Adult, Aged, Alanine Transaminase, Aspartate Aminotransferases, China, Cross-Sectional Studies, Fatty Liver, Female, Fibronectins, Humans, Liver, Male, Middle Aged, Magnetic Resonance Spectroscopy, Obesity, Triglycerides, Asian People, Non-alcoholic Fatty Liver Disease

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