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Irisin is inversely associated with intrahepatic triglyceride contents in obese adults
Abstract
Background & aims Obesity is closely related to non-alcoholic fatty liver disease (NAFLD), which has become an important public health problem because of its high prevalence and association with metabolic syndromes. Irisin was recently identified as a novel peptide to improve obesity and glucose homeostasis, and considered to be therapeutic for human metabolic diseases. The aim of this study was to examine the association of serum irisin concentration and liver triglyceride contents in obese Chinese adults.Methods Serum irisin levels were measured and liver fat contents determined by (1)H MRS in 296 obese adults. Anthropometric parameters and blood biochemical indexes including liver enzymes, glucose, and lipid profiles were detected. The liver triglyceride contents of subjects were measured by (1)H MRS. The protein levels of irisin were determined by quantitative ELISA.Results We found that serum irisin levels were reduced in obese adults with NAFLD. By dividing the distribution of intrahepatic triglyceride (IHTG) contents into quartiles, serum irisin levels were reduced gradually with the increase of IHTG contents (p<0.01). Higher serum irisin levels were associated with preferable TG levels. Serum ALT and AST concentrations were inversely correlated with serum irisin levels. Multivariate linear regression analysis demonstrated that serum irisin levels were independently associated with liver fat (p<0.01). By logistic regression analysis, the odds ratio for higher IHTG contents was reduced by 12.4% per 1 SD increase in serum irisin concentrations after adjustment for multivariate metabolic factors [OR (95% CI); 0.876 (0.777-0.987)].Conclusions These results demonstrated that serum irisin concentrations were inversely associated with the triglyceride contents in the liver and liver enzymes in obese Chinese adults.
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“an inverse association between irisin concentrations and hepatic TG content in adults has been recently reported [281].”
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Irisin and its Effects on the Metabolic Diseases
Baig, M. F., Khan, M. K. A., Mahnoor, Perveen, M., Atif, M., Younas, U., & Sharif, S. (2023) · Pakistan BioMedical Journal · doi:10.54393/pbmj.v6i07.905 · Cited by 3
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EVALUATION OF SERUM IRISIN WITH LIPID PROFILE IN TYPE-2 DIABETIC PATIENTS IN SULAIMANI
Maarouf, F. B., Mohammed, M., Omer, N. A., & Nore, B. F. (2018) · Journal of Sulaimani Medical College · doi:10.17656/jsmc.10160 · Cited by 2
Liver, Muscle, and Insulin Resistance in Obese Subjects: Exercise Effects
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Lu, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1074842 · Cited by 2
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Metadata
- Authors
- Zhang, H.-J., Zhang, X.-F., Ma, Z.-M., Pan, L.-L., Chen, Z., Han, H.-W., Han, C.-K., Zhuang, X.-J., Lu, Y., Li, X.-J., Yang, S.-Y., & Li, X.-Y.
- Affiliations
- Xiamen University (CN)
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Li, Xiao-Ying
- ORCID
- Chen, Zheng
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 59
- Issue
- 3
- Pages
- 557-562
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2101439943
- Cited by
- 234
- References
- 34
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 15 · 2023: 7 · 2022: 29 · 2021: 13 · 2020: 22 · 2019: 11 · 2018: 21 · 2017: 21 · 2016: 22 · 2015: 26 · 2014: 18 · 2013: 11
- FWCI
- 18.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- irisin, intrahepatic triglyceride, non-alcoholic fatty liver disease, obesity, hepatic steatosis, liver fat, alanine aminotransferase, aspartate aminotransferase, serum biomarkers, Chinese adults
- MeSH terms
- Adult, Aged, Alanine Transaminase, Aspartate Aminotransferases, China, Cross-Sectional Studies, Fatty Liver, Female, Fibronectins, Humans, Liver, Male, Middle Aged, Magnetic Resonance Spectroscopy, Obesity, Triglycerides, Asian People, Non-alcoholic Fatty Liver Disease
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