Cited by 128Liver Diseases and ImmunityHealth and Well-being StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Health-related quality of life, depression, and anxiety in patients with autoimmune hepatitis

Schramm, Christoph, Wahl, Inka, Weiler-Normann, Christina, Voigt, Katharina, Wiegard, Christiane, Glaubke, Claudia, Brähler, Elmar, Löwe, Bernd, Lohse, Ansgar W., Rose, Matthias·2014·Journal of Hepatology

DOI 10.1016/j.jhep.2013.10.035

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Abstract

Background & aims Improving health related quality of life (HrQoL) in patients with chronic diseases such as autoimmune hepatitis (AIH) should be a major treatment goal. However, little is known on the HrQoL in patients with AIH, and the topic is not given attention in current practice guidelines. We therefore conducted a single center study evaluating HrQoL in 103 consecutive outpatients with AIH.Methods Patient-reported HrQoL data were analysed in relation to clinical disease parameters and compared to representative data of the German population as well as control patients.Results Based on patient-reported data, a major depressive syndrome (10.8%) was found to be five times more frequent in AIH patients compared to the general population (p<0.001). The rate of severe symptoms of anxiety was also found to be significantly increased compared to the general population (p=0.006). In seven of the eleven patients who scored for a major depressive syndrome a psychiatric comorbidity had not been diagnosed before. Major factors associated with depression and anxiety were concerns with regard to the progression of the liver disease.Conclusions This study identified--for the first time--a high rate of previously unrecognized severe symptoms of depression and anxiety in patients with AIH. Of importance for daily clinical practice, the factors associated with these symptoms may in part be amenable to targeted counselling and adequate treatment of the disease, thereby offering the chance to improve the care and HrQoL of AIH-patients.

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Authors: Schramm, C., Wahl, I., Weiler-Normann, C., Voigt, K., Wiegard, C., Glaubke, C., Brähler, E., Löwe, B., Lohse, A. W., & Rose, M.
Affiliations: University Medical Center Hamburg-Eppendorf (DE)
Schön Klinik Hamburg Eilbek (DE)
Leipzig University (DE)
Corresponding author: Schramm, Christoph
ORCID: Schramm, Christoph
Brähler, Elmar
Löwe, Bernd
Lohse, Ansgar W.
Rose, Matthias
Venue: Journal of Hepatology
Publisher: Elsevier BV
Published: 2014-03
Volume: 60
Issue: 3
Pages: 618-624
ISSN: 0168-8278 (ISSN-L)
DOI: 10.1016/j.jhep.2013.10.035
OpenAlex: W1972531935
Cited by: 128
References: 36
Citations by year: 2026: 12 · 2025: 16 · 2024: 11 · 2023: 15 · 2022: 8 · 2021: 13 · 2020: 11 · 2019: 12 · 2018: 15 · 2017: 4 · 2016: 1 · 2015: 6 · 2014: 3
FWCI: 2.07
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Hepatology (publishedVersion)
PubMed (publishedVersion)
Funders: Alberta Innovates - Health Solutions
Topics: Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
Social Sciences › Psychology › Clinical Psychology › Health and Well-being Studies
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: autoimmune hepatitis, health-related quality of life, depression, anxiety, psychiatric comorbidity, patient-reported outcomes, chronic liver disease
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Anxiety, Depression, Female, Humans, Male, Middle Aged, Quality of Life, Hepatitis, Autoimmune

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Health-related quality of life, depression, and anxiety in patients with autoimmune hepatitis

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