Unmet clinical need in autoimmune liver diseases
Open accessAbstract
Despite recent advances in understanding and treatment, there remain significant areas of unmet clinical need in each of the autoimmune liver diseases (AILDs). The evolving research landscape and emerging large patient cohorts are creating unique opportunities to translate science into new therapies and care pathways, with the potential to significantly improve the lives of AILD patients. However, the areas of unmet need represent real challenges, which need to be addressed, if this vision is to be realised. This review describes the areas of unmet need in AILD in adults relating to diagnostic and prognostic assessment, primary therapy, symptom management, trial design and delivery, and structured care delivery, with the aim of focusing future research prioritisation.
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For many years following the original UDCA trials there has been little or no trials activity in PBC; this is now changing with a number of trials targeting areas of perceived unmet clinic need, with progress to new licensed second-line therapies such as OCA, which has FDA and EMA approval.
“For many years following the original UDCA trials there has been little or no trials activity in PBC. This is now changing with a number of trials targeting areas of perceived unmet clinic need in the condition,260 261 with progress to new licensed second-line therapies such as OCA,158 which has FDA and EMA approval, as well as NICE evaluation in the UK.”
From The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines (2018) · cites this paper as [261]
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- Authors
- Dyson, J. K., Webb, G., Hirschfield, G. M., Lohse, A., Beuers, U., Lindor, K., & Jones, D. E. J.
- Affiliations
- Freeman Hospital (GB)
- NIHR Birmingham Liver Biomedical Research Unit (GB)
- University Medical Center Hamburg-Eppendorf (DE)
- Amsterdam University Medical Centers (NL)
- Arizona State University (US)
- Corresponding author
- Jones, David E.J.
- ORCID
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 62
- Issue
- 1
- Pages
- 208-218
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2033549902
- Cited by
- 66
- References
- 114
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 9 · 2017: 8 · 2016: 10 · 2015: 10 · 2014: 1
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Hepatology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, cc-by-nc-nd)
- Newcastle University ePrints (Newcastle Univesity) (cc-by)
- Funders
- National Institute for Health and Care Research (IS-BRC-0211-10046, NF-SI-0513-10091)
- Medical Research Council (MR/L001489/1, MR/K501037/1, MR/M001911/1)
- NIHR Newcastle Biomedical Research Centre (BH141402, BH134330, BH121729, BH137357)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Rheumatology › IgG4-Related and Inflammatory Diseases
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Keywords
- autoimmune liver disease, unmet clinical needs, diagnostic assessment, prognostic assessment, primary treatment, symptom management, clinical trial design, health care delivery, research prioritization
- MeSH terms
- Autoimmune Diseases, Humans, Liver Diseases, Prognosis, Autoimmunity, Disease Management
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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