Cited by 66Liver Diseases and ImmunityIgG4-Related and Inflammatory DiseasesPediatric Hepatobiliary Diseases and Treatments

Unmet clinical need in autoimmune liver diseases

Open access
Dyson, Jessica K., Webb, Gwilym, Hirschfield, Gideon M., Lohse, Ansgar, Beuers, Ulrich, Lindor, Keith, Jones, David E.J.·2015·Journal of Hepatology

Abstract

Despite recent advances in understanding and treatment, there remain significant areas of unmet clinical need in each of the autoimmune liver diseases (AILDs). The evolving research landscape and emerging large patient cohorts are creating unique opportunities to translate science into new therapies and care pathways, with the potential to significantly improve the lives of AILD patients. However, the areas of unmet need represent real challenges, which need to be addressed, if this vision is to be realised. This review describes the areas of unmet need in AILD in adults relating to diagnostic and prognostic assessment, primary therapy, symptom management, trial design and delivery, and structured care delivery, with the aim of focusing future research prioritisation.

Integrity signals

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Crossref · 10.1016/j.jhep.2014.09.010

Cites

111 of 111 references verified0 citation errors · 0 not checkable

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  • For many years following the original UDCA trials there has been little or no trials activity in PBC; this is now changing with a number of trials targeting areas of perceived unmet clinic need, with progress to new licensed second-line therapies such as OCA, which has FDA and EMA approval.

    “For many years following the original UDCA trials there has been little or no trials activity in PBC. This is now changing with a number of trials targeting areas of perceived unmet clinic need in the condition,260 261 with progress to new licensed second-line therapies such as OCA,158 which has FDA and EMA approval, as well as NICE evaluation in the UK.”

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Authors
Dyson, J. K., Webb, G., Hirschfield, G. M., Lohse, A., Beuers, U., Lindor, K., & Jones, D. E. J.
Affiliations
  • Freeman Hospital (GB)
  • NIHR Birmingham Liver Biomedical Research Unit (GB)
  • University Medical Center Hamburg-Eppendorf (DE)
  • Amsterdam University Medical Centers (NL)
  • Arizona State University (US)
Corresponding author
Jones, David E.J.
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
2015-01
Volume
62
Issue
1
Pages
208-218
ISSN
0168-8278 (ISSN-L)
OpenAlex
W2033549902
Cited by
66
References
114
Citations by year
2026: 3 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 9 · 2017: 8 · 2016: 10 · 2015: 10 · 2014: 1
FWCI
1.26
Type
journal article
Language
en
Open access
Locations
  • Journal of Hepatology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion, cc-by-nc-nd)
  • Newcastle University ePrints (Newcastle Univesity) (cc-by)
Funders
  • National Institute for Health and Care Research (IS-BRC-0211-10046, NF-SI-0513-10091)
  • Medical Research Council (MR/L001489/1, MR/K501037/1, MR/M001911/1)
  • NIHR Newcastle Biomedical Research Centre (BH141402, BH134330, BH121729, BH137357)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
  • Health Sciences › Medicine › Rheumatology › IgG4-Related and Inflammatory Diseases
  • Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
Keywords
autoimmune liver disease, unmet clinical needs, diagnostic assessment, prognostic assessment, primary treatment, symptom management, clinical trial design, health care delivery, research prioritization
MeSH terms
Autoimmune Diseases, Humans, Liver Diseases, Prognosis, Autoimmunity, Disease Management

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