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Health-related quality of life, depression, and anxiety in patients with autoimmune hepatitis
Abstract
Background & aims Improving health related quality of life (HrQoL) in patients with chronic diseases such as autoimmune hepatitis (AIH) should be a major treatment goal. However, little is known on the HrQoL in patients with AIH, and the topic is not given attention in current practice guidelines. We therefore conducted a single center study evaluating HrQoL in 103 consecutive outpatients with AIH.Methods Patient-reported HrQoL data were analysed in relation to clinical disease parameters and compared to representative data of the German population as well as control patients.Results Based on patient-reported data, a major depressive syndrome (10.8%) was found to be five times more frequent in AIH patients compared to the general population (p<0.001). The rate of severe symptoms of anxiety was also found to be significantly increased compared to the general population (p=0.006). In seven of the eleven patients who scored for a major depressive syndrome a psychiatric comorbidity had not been diagnosed before. Major factors associated with depression and anxiety were concerns with regard to the progression of the liver disease.Conclusions This study identified--for the first time--a high rate of previously unrecognized severe symptoms of depression and anxiety in patients with AIH. Of importance for daily clinical practice, the factors associated with these symptoms may in part be amenable to targeted counselling and adequate treatment of the disease, thereby offering the chance to improve the care and HrQoL of AIH-patients.
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“Schramm and colleagues reported that the frequency of self-reported DEP and moderate ANX among 103 German patients with AIH to be twice that observed in the German general population (ie, 5.9% vs. 2.6% DEP and 8.3% vs. 4.4% ANX).”
From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [27]
In the citing paper
“Schramm and colleagues reported that the frequency of self-reported DEP and moderate ANX among 103 German patients with AIH to be twice that observed in the German general population (ie, 5.9% vs. 2.6% DEP and 8.3% vs. 4.4% ANX).”
From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [27]
In the citing paper
“Further, 10.8% of patients with AIH met criteria for MDD and 4.2% presented with severe ANX, which were respectively, 5 and 4 times greater than rates in the general population (ie, 1.9% MDD and 1.1% ANX).[27]”
From Prevalence of depression and anxiety symptoms by liver disease etiology (2023) · cites this paper as [27]
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EASL Clinical Practice Guidelines: autoimmune hepatitis
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Metadata
- Authors
- Schramm, C., Wahl, I., Weiler-Normann, C., Voigt, K., Wiegard, C., Glaubke, C., Brähler, E., Löwe, B., Lohse, A. W., & Rose, M.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Schön Klinik Hamburg Eilbek (DE)
- Leipzig University (DE)
- Corresponding author
- Schramm, Christoph
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 60
- Issue
- 3
- Pages
- 618-624
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W1972531935
- Cited by
- 128
- References
- 36
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 11 · 2023: 15 · 2022: 8 · 2021: 13 · 2020: 11 · 2019: 12 · 2018: 15 · 2017: 4 · 2016: 1 · 2015: 6 · 2014: 3
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alberta Innovates - Health Solutions
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Social Sciences › Psychology › Clinical Psychology › Health and Well-being Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- autoimmune hepatitis, health-related quality of life, depression, anxiety, psychiatric comorbidity, patient-reported outcomes, chronic liver disease
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Anxiety, Depression, Female, Humans, Male, Middle Aged, Quality of Life, Hepatitis, Autoimmune
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