Active at night, sleepy all day – Sleep disturbances in patients with hepatitis C virus infection
Abstract
Background & aims More than 50% of patients with chronic hepatitis C with only mild liver disease complain about chronic fatigue, daytime sleepiness and poor sleep quality. The aim of the present study was to characterize and objectify the sleep disturbances in hepatitis C virus-infected patients.Methods Twenty-five women who had been infected with hepatitis C virus contaminated anti-D immunoglobulin in 1978/79 and 22 age-matched female healthy controls underwent actigraphy over a period of 5 days to measure motor activity and thereby sleep-wake-rhythm and in addition completed questionnaires for depression, health-related quality of life, fatigue and sleep, and a sleep diary. Liver cirrhosis, a history of neurological or psychiatric disease, history of intravenous drug abuse, shift work, or current medication with effect upon the central nervous system were exclusion criteria.Results The patients achieved higher scores for depression, fatigue and sleep disturbances and lower quality of life scores than the healthy controls. Actigraphy showed higher nocturnal activity and worse sleep efficiency in the patients, while the 24-h activity level did not differ between groups. Fatigue and quality of life scores correlated with bad sleep quality and daytime sleepiness.Conclusions Our data indicate that chronic fatigue is associated with bad sleep quality and increased nocturnal activity in HCV-infected patients suggesting an alteration of sleep architecture behind fatigue in HCV-associated encephalopathy.
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IL-6 reactivity following a series of cognitive challenges was higher in men and postmenopausal women age 50 and older who reported poor sleep quality, compared with those reporting good sleep quality.
“IL-6 reactivity following a series of cognitive challenges was higher in men and postmenopausal women age 50 and older who reported poor sleep quality, compared with those reporting good sleep quality”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [233]
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- Authors
- Heeren, M., Sojref, F., Schuppner, R., Worthmann, H., Pflugrad, H., Tryc, A. B., Pasedag, T., & Weissenborn, K.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Weissenborn, Karin
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 60
- Issue
- 4
- Pages
- 732-740
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W1997142340
- Cited by
- 46
- References
- 42
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 2
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- hepatitis C, chronic fatigue, sleep disorders, daytime sleepiness, sleep quality, nocturnal activity, actigraphy, depression, health-related quality of life
- MeSH terms
- Depression, Fatigue, Female, Humans, Middle Aged, Quality of Life, Surveys and Questionnaires, Case-Control Studies, Hepatitis C, Chronic, Sleep Disorders, Circadian Rhythm, Actigraphy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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