The Role of Cytokines in Sleep Regulation
Open accessAbstract
Interleukin-1 beta (IL1) and tumor necrosis factor alpha (TNF) promote non-rapid eye movement sleep under physiological and inflammatory conditions. Additional cytokines are also likely involved but evidence is insufficient to conclude that they are sleep regulatory substances. Many of the symptoms induced by sleep loss, e.g. sleepiness, fatigue, poor cognition, enhanced sensitivity to pain, can be elicited by injection of exogenous IL1 or TNF. We propose that ATP, released during neurotransmission, acting via purine P2 receptors on glia releases IL1 and TNF. This mechanism may provide the means by which the brain keeps track of prior usage history. IL1 and TNF in turn act on neurons to change their intrinsic properties and thereby change input-output properties (i.e. state shift) of the local network involved. Direct evidence indicates that cortical columns oscillate between states, one of which shares properties with organism sleep. We conclude that sleep is a local use-dependent process influenced by cytokines and their effector molecules such as nitric oxide, prostaglandins and adenosine.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
IL-1 and TNF stimulate NF-κB, a DNA-binding protein involved in transcription of hundreds of gene products.
“IL-1 and TNF stimulate NF-κB, a DNA-binding protein involved in transcription of hundreds of gene products.”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Krueger, 2008
Administration of either IL-1 or TNF promotes NREM sleep.
“Administration of either IL-1 or TNF promotes NREM sleep (Obal and Krueger, 2003;Opp, 2005;Krueger, 2008).”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Krueger, 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804 · see citing works
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151 · see citing works
Huber, R., Felice Ghilardi, M., Massimini, M., & Tononi, G. (2004) · Nature · doi:10.1038/nature02663 · Cited by 1,854 · see citing works
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798 · see citing works
Coordinated memory replay in the visual cortex and hippocampus during sleep
Ji, D., & Wilson, M. A. (2007) · Nature Neuroscience · doi:10.1038/nn1825 · Cited by 1,669 · see citing works
Physiology and Pathophysiology of Purinergic Neurotransmission
Burnstock, G. (2007) · Physiological Reviews · doi:10.1152/physrev.00043.2006 · Cited by 1,579 · see citing works
Behavioral and Physiological Consequences of Sleep Restriction
Banks, S., & Dinges, D. F. (2007) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26918 · Cited by 1,505 · see citing works
The role of sleep in learning and memory
Maquet, P. (2001) · Science · doi:10.1126/science.1062856 · Cited by 1,177 · see citing works
Kawasaki, Y., Zhang, L., Cheng, J.-K., & Ji, R.-R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3338-07.2008 · Cited by 1,162 · see citing works
The P2X7 Receptor: A Key Player in IL-1 Processing and Release
Ferrari, D., Pizzirani, C., Adinolfi, E., Lemoli, R. M., Curti, A., Idzko, M., Panther, E., & Di Virgilio, F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.3877 · Cited by 1,025 · see citing works
Altered Cytokine Production in Mice Lacking P2X7Receptors
Solle, M., Labasi, J. M., Perregaux, D. G., Stam, E. J., Petrushova, N., Koller, B. H., Griffiths, R., & Gabel, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006781200 · Cited by 924 · see citing works
Restoration of brain energy metabolism as the function of sleep
Benington, J. H., & Heller, H. C. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(94)00057-o · Cited by 828 · see citing works
Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity
Dantzer, R. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.040 · Cited by 743 · see citing works
The neurotrophin hypothesis for synaptic plasticity
Schinder, A. F. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01672-6 · Cited by 729 · see citing works
Jager, J., Grémeaux, T., Cormont, M., MARCHAND‐BRUSTEL, Y. L., & Tanti, J. (2006) · Endocrinology · doi:10.1210/en.2006-0692 · Cited by 695 · see citing works
Astrocyte-Derived ATP Induces Vesicle Shedding and IL-1β Release from Microglia
Bianco, F., Pravettoni, E., Colombo, A., Schenk, U., Möller, T., Matteoli, M., & Verderio, C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7268 · Cited by 596 · see citing works
Adenosine and sleep–wake regulation
Basheer, R., Strecker, R. E., Thakkar, M. M., & McCarley, R. W. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.06.004 · Cited by 589 · see citing works
Arm immobilization causes cortical plastic changes and locally decreases sleep slow wave activity
Huber, R., Ghilardi, M. F., Massimini, M., Ferrarelli, F., Riedner, B. A., Peterson, M. J., & Tononi, G. (2006) · Nature Neuroscience · doi:10.1038/nn1758 · Cited by 579 · see citing works
Jones, B. E. (2003) · Frontiers in bioscience · doi:10.2741/1074 · Cited by 532 · see citing works
Sleep Enhances Plasticity in the Developing Visual Cortex
Frank, M. G., Issa, N. P., & Stryker, M. P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00279-3 · Cited by 523 · see citing works
The corticothalamic system in sleep
Steriade, M. (2003) · Frontiers in bioscience · doi:10.2741/1043 · Cited by 504 · see citing works
Sleep-promoting effects of endogenous pyrogen (interleukin-1)
Krueger, J. M., Walter, J., Dinarello, C. A., Wolff, S. M., & CHEDID, L. A. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.246.6.r994 · Cited by 456 · see citing works
Self-citationExtracellular ATP Triggers Tumor Necrosis Factor‐α Release from Rat Microglia
Hide, I., Tanaka, M., Inoue, A., Nakajima, K., Kohsaka, S., Inoue, K., & Nakata, Y. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750965.x · Cited by 447 · see citing works
TNF-α suppresses the expression of clock genes by interfering with E-box-mediated transcription
Cavadini, G., Petrzilka, S., Kohler, P. P., Jud, C., Tobler, I., Birchler, T., & Fontana, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701466104 · Cited by 421 · see citing works
Honoré, P., Donnelly‐Roberts, D. L., Namovic, M. T., Hsieh, G. C., Zhu, C., Mikusa, J. P., Hernandez, G., Zhong, C., Gauvin, D. M., Chandran, P., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.111559 · Cited by 418 · see citing works
Effect of unilateral somatosensory stimulation prior to sleep on the sleep EEG in humans
KATTLER, H., DIJK, D., & BORBÉLY, A. A. (1994) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1994.tb00123.x · Cited by 401 · see citing works
Suzuki, T., Hide, I., Ido, K., Kohsaka, S., Inoue, K., & Nakata, Y. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3792-03.2004 · Cited by 394 · see citing works
Opp, M. R. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.01.002 · Cited by 393 · see citing works
Vgontzas, A. N., Zoumakis, E., Lin, H. ‐., Bixler, E. O., Trakada, G., & Chrousos, G. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031929 · Cited by 338 · see citing works
Insights from studying human sleep disorders
Mahowald, M. W., & Schenck, C. H. (2005) · Nature · doi:10.1038/nature04287 · Cited by 330 · see citing works
The effects of 40 hours of total sleep deprivation on inflammatory markers in healthy young adults
Frey, D. J., Fleshner, M., & Wright, K. P. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.04.003 · Cited by 330 · see citing works
Biochemical regulation of non-rapid-eye-movement sleep
Krueger, J. M. (2003) · Frontiers in Bioscience · doi:10.2741/1033 · Cited by 329 · see citing works
Self-citationA neuronal group theory of sleep function
Krueger, J. M., & Obál, F. (1993) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1993.tb00064.x · Cited by 314 · see citing works
Self-citationThe Effects of Total Sleep Deprivation on Cerebral Responses to Cognitive Performance
Drummond, S. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00325-6 · Cited by 306 · see citing works
Cytokines, stress and depressive illness: Brain-immune interactions.
Anisman, H., & Merali, Z. (2003) · Annals of Medicine · doi:10.1080/07853890310004075 · Cited by 302 · see citing works
A Causal Role for Brain-Derived Neurotrophic Factor in the Homeostatic Regulation of Sleep
Faraguna, U., Vyazovskiy, V. V., Nelson, A. B., Tononi, G., & Cirelli, C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5510-07.2008 · Cited by 300 · see citing works
Datta, S., & MacLean, R. R. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.02.004 · Cited by 296 · see citing works
A functional role for REM sleep in brain maturation.
Marks, G. A., Shaffery, J., Oksenberg, A., Speciale, S., & Roffwarg, H. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00018-o · Cited by 276 · see citing works
Pappenheimer, J. R., Koski, G., Fencl, V., Karnovsky, M. L., & Krueger, J. M. (1975) · Journal of Neurophysiology · doi:10.1152/jn.1975.38.6.1299 · Cited by 270 · see citing works
Self-citationEndogenous sleep-promoting substances and sleep regulation
Borbely, A. A., & Tobler, I. (1989) · Physiological Reviews · doi:10.1152/physrev.1989.69.2.605 · Cited by 259 · cited 2× · see citing works
“it is enhanced during the deep sleep that follows sleep deprivation [35,88].”
BackgroundFoltenyi, K., Greenspan, R. J., & Newport, J. W. (2007) · Nature Neuroscience · doi:10.1038/nn1957 · Cited by 235 · see citing works
Pro-inflammatory cytokines and their effects in the dentate gyrus
Pickering, M., & O’Connor, J. J. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)63020-9 · Cited by 217 · see citing works
Vyazovskiy, V., Borbély, A. A., & Tobler, I. (2000) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2000.00230.x · Cited by 203 · see citing works
Vollmer-Conna, U. S., Fazou, C., Cameron, B., LI, H., Brennan, C. M., LUCK, L., Davenport, T. A., Wakefield, D., Hickie, I. B., & Lloyd, A. R. (2004) · Psychological Medicine · doi:10.1017/s0033291704001953 · Cited by 195 · see citing works
Hypothalamic regulation of sleep and arousal
McGinty, D. (2003) · Frontiers in bioscience · doi:10.2741/1159 · Cited by 178 · see citing works
Sleep-promoting effects of cerebrospinal fluid from sleep-deprived goats.
Pappenheimer, J. R., Miller, T. B., & Goodrich, C. A. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.58.2.513 · Cited by 177 · see citing works
Role of inflammation in the progression of heart failure
Yndestad, A., Damås, J. K., Øie, E., Ueland, T., Gullestad, L. L., & Aukrust, P. (2007) · Current Cardiology Reports · doi:10.1007/bf02938356 · Cited by 177 · see citing works
Rhythmic electrical activity from isolated cerebral cortex
Kristiansen, K., & Courtois, G. (1949) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(49)90191-1 · Cited by 172 · see citing works
Mice Lacking the TNF 55 kDa Receptor Fail to Sleep More After TNFα Treatment
Fang, J., Wang, Y., & Krueger, J. M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05949.1997 · Cited by 167 · see citing works
Self-citationPurinergic signaling and microglia
Färber, K., & Kettenmann, H. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0064-7 · Cited by 163 · see citing works
Alteration of sleep in rabbits by Staphylococcus aureus infection
Toth, L. A., & Krueger, J. M. (1988) · Infection and Immunity · doi:10.1128/iai.56.7.1785-1791.1988 · Cited by 159 · see citing works
Self-citationLocal functional state differences between rat cortical columns
Rector, D. M., Topchiy, I., Carter, K. M., & Rojas, M. J. (2005) · Brain Research · doi:10.1016/j.brainres.2005.04.002 · Cited by 159 · see citing works
Effects of interleukin-1β on sleep are mediated by the type I receptor
Fang, J., Wang, Y., & Krueger, J. M. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.3.r655 · Cited by 152 · see citing works
Self-citationInterleukin 1-receptor antagonist blocks interleukin 1-induced sleep and fever
Opp, M. R., & Krueger, J. M. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.260.2.r453 · Cited by 152 · see citing works
Self-citationKapsimalis, F., Richardson, G. S., Opp, M. R., & Kryger, M. H. (2005) · Current Opinion in Pulmonary Medicine · doi:10.1097/01.mcp.0000183062.98665.6b · Cited by 150 · see citing works
Krueger, J. M., Rector, D. M., & Churchill, L. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.03.003 · Cited by 127 · see citing works
Self-citationInteraction Between Sleep and the Immune Response in Drosophila: A Role for the NFκB Relish
Williams, J. A., Sathyanarayanan, S., Hendricks, J. C., & Sehgal, A. (2007) · Sleep · doi:10.1093/sleep/30.4.389 · Cited by 126 · see citing works
Unihemispheric slow wave sleep and the state of the eyes in a white whale
Lyamin, O. I., Mukhametov, L. M., Siegel, J. M., Nazarenko, E. A., Polyakova, I. G., & Shpak, O. V. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00346-1 · Cited by 118 · see citing works
Alam, M. N., McGinty, D., Bashir, T., Kumar, S., Imeri, L., Opp, M. R., & Szymusiak, R. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03469.x · Cited by 108 · see citing works
The effects of immunolesions of nerve growth factor-receptive neurons by 192 IgG-saporin on sleep
Kapás, L., Obál, F., Book, A. A., Schweitzer, J. B., Wiley, R. G., & Krueger, J. M. (1996) · Brain Research · doi:10.1016/0006-8993(95)01431-4 · Cited by 107 · see citing works
Self-citationDepino, A. M., Alonso, M., Ferrari, C. C., del Rey, A., Anthony, D. C., Besedovsky, H. O., Medina, J. H., & Pitossi, F. J. (2003) · Hippocampus · doi:10.1002/hipo.10164 · Cited by 105 · see citing works
Experience-dependent slow-wave sleep development
Miyamoto, H., Katagiri, H., & Hensch, T. K. (2003) · Nature Neuroscience · doi:10.1038/nn1064 · Cited by 102 · see citing works
Baune, B. T., Ponath, G. D., Rothermundt, M., Rieß, O., Funke, H., & Berger, K. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.10.002 · Cited by 101 · see citing works
Hu, J., Chen, Z., Gorczynski, C. P., Gorczynski, L. Y., Kai, Y., Lee, L., Manuel, J., & Gorczynski, R. M. (2003) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2003.03.001 · Cited by 101 · see citing works
Fatal familial insomnia: a model disease in sleep physiopathology
Montagna, P. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.02.001 · Cited by 101 · see citing works
Manfridi, A., Brambilla, D., Bianchi, S., Mariotti, M., Opp, M. R., & Imeri, L. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02836.x · Cited by 101 · see citing works
Role of brain IL-1β on fatigue after exercise-induced muscle damage
Carmichael, M. D., Davis, J. M., Murphy, E. A., Brown, A. S., Carson, J. A., Mayer, E. P., & Ghaffar, A. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00141.2006 · Cited by 98 · see citing works
Sleep, neuroimmune and neuroendocrine functions in fibromyalgia and chronic fatigue syndrome
Moldofsky, H. (1995) · Advances in Neuroimmunology · doi:10.1016/0960-5428(94)00048-s · Cited by 95 · see citing works
Brain-derived neurotrophic factor enhances spontaneous sleep in rats and rabbits
Kushikata, T., Fang, J., & Krueger, J. M. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.5.r1334 · Cited by 95 · see citing works
Self-citationKrueger, J. M. (2003) · Frontiers in bioscience · doi:10.2741/1031 · Cited by 94 · see citing works
Self-citationBasheer, R., Rainnie, D. G., Porkka‐Heiskanen, T., Ramesh, V., & McCarley, R. W. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00111-7 · Cited by 93 · see citing works
Intrapreoptic microinjection of TNF-α enhances non-REM sleep in rats
Kubota, T., Li, N., Guan, Z., Brown, R. A., & Krueger, J. M. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02262-x · Cited by 92 · see citing works
Self-citationState-specific asymmetries in EEG slow wave activity induced by local application of TNFα
Yoshida, H., Peterfi, Z., García‐García, F., Kirkpatrick, R. J., Yasuda, T., & Krueger, J. M. (2004) · Brain Research · doi:10.1016/j.brainres.2004.02.055 · Cited by 90 · see citing works
Self-citationGambino, F., Pavlowsky, A., Béglé, A., Dupont, J. L., Bahi‐Buisson, N., Courjaret, R. J., Gardette, R., Hadj-Kacem, H., Skala, H., Poulain, B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701133104 · Cited by 89 · see citing works
Sleep-Associated Changes in Interleukin-1β mRNA in the Brain
TAISHI, P., CHEN, Z., OBÁL, F., HANSEN, M. K., ZHANG, J., FANG, J., & KRUEGER, J. M. (1998) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1998.18.793 · Cited by 88 · see citing works
Self-citationMetabolic syndrome – Neurotrophic hypothesis
Hristova, M., & Aloe, L. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.08.055 · Cited by 87 · see citing works
Nuclear factor-κB inhibitor peptide inhibits spontaneous and interleukin-1β-induced sleep
Kubota, T., Kushikata, T., Fang, J., & Krueger, J. M. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.2.r404 · Cited by 83 · see citing works
Self-citationEvidence for activation of nuclear factor kappaB in obstructive sleep apnea
Yamauchi, M., Tamaki, S., Tomoda, K., Yoshikawa, M., Fukuoka, A., Makinodan, K., Koyama, N., Suzuki, T., & Kimura, H. (2006) · Sleep And Breathing · doi:10.1007/s11325-006-0074-x · Cited by 82 · see citing works
Nuclear factor-κB-like activity increases in murine cerebral cortex after sleep deprivation
Chen, Z., Gardi, J., Kushikata, T., Fang, J., & Krueger, J. M. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.6.r1812 · Cited by 78 · see citing works
Self-citationDechant, G., & Neumann, H. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0123-7_11 · Cited by 75 · see citing works
Trompet, S., de Craen, A. J. M., Slagboom, P. E., Shepherd, J., Blauw, G. J., Murphy, M. B., Bollen, E. L. E. M., Buckley, B. M., Ford, I., Gaw, A. J., et al. (2008) · Brain · doi:10.1093/brain/awn023 · Cited by 74 · see citing works
Handedness Leads to Interhemispheric EEG Asymmetry During Sleep in the Rat
Vyazovskiy, V. V., & Tobler, I. (2007) · Journal of Neurophysiology · doi:10.1152/jn.01154.2007 · Cited by 73 · see citing works
The effect of interleukin-1 blockade on fatigue in rheumatoid arthritis—a pilot study
Omdal, R., & Gunnarsson, R. (2004) · Rheumatology International · doi:10.1007/s00296-004-0463-z · Cited by 71 · see citing works
GHRH and IL1β increase cytoplasmic Ca2+ levels in cultured hypothalamic GABAergic neurons
De, A., Churchill, L., Obál, F., Simasko, S. M., & Krueger, J. M. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03157-8 · Cited by 70 · see citing works
Self-citationKundermann, B., Hemmeter-Spernal, J., Huber, M., Krieg, J.-C., & Lautenbacher, S. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31815c1b5d · Cited by 68 · see citing works
Yasuda, T., Yoshida, H., García‐García, F., Kay, D. B., & Krueger, J. M. (2005) · SLEEP · doi:10.1093/sleep/28.2.177 · Cited by 68 · see citing works
Self-citationSleep and dynamic stabilization of neural circuitry: A review and synthesis
Kavanau, J. L. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90082-5 · Cited by 66 · see citing works
Unilateral Eye Closure and Interhemispheric EEG Asymmetry during Sleep in the Pigeon (Columba livia)
Rattenborg, N. C., Amlaner, C. J., & Lima, S. L. (2001) · Brain Behavior and Evolution · doi:10.1159/000057573 · Cited by 62 · see citing works
Sleep deprivation increases the activation of nuclear factor kappa B in lateral hypothalamic cells
Brandt, J. A., Churchill, L., Rehman, A., Ellis, G., Mémet, S., Israël, A., & Krueger, J. M. (2004) · Brain Research · doi:10.1016/j.brainres.2003.11.079 · Cited by 61 · see citing works
Self-citation[Neuromediators and hypnogenic factors].
Jouvet, M. (1984) · PubMed · Cited by 61 · see citing works
Enhancement of slow-wave sleep by tumor necrosis factor-α is mediated by cyclooxygenase-2 in rats
Terao, A., Matsumura, H., Yoneda, H., & Saito, M. (1998) · NeuroReport · doi:10.1097/00001756-199812010-00005 · Cited by 60 · see citing works
Sarro, G. D., Gareri, P., Sinopoli, V. A., David, E., & Rotiroti, D. (1997) · Life Sciences · doi:10.1016/s0024-3205(96)00692-3 · Cited by 60 · see citing works
Takahashi, S., Kapás, L., Fang, J., Seyer, J. M., Wang, Y., & Krueger, J. M. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.1.r101 · Cited by 60 · see citing works
Self-citationVyazovskiy, V. V., Welker, E., Fritschy, J., & Tobler, I. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03583.x · Cited by 58 · see citing works
A network model for activity-dependent sleep regulation
Roy, S., Krueger, J. M., Rector, D. M., & Wan, Y. (2008) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2008.03.033 · Cited by 56 · see citing works
Self-citationEpidermal growth factor enhances spontaneous sleep in rabbits
Kushikata, T., Fang, J., Chen, Z., Wang, Y., & Krueger, J. M. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.2.r509 · Cited by 56 · see citing works
Self-citationAdenosine and sleep deprivation promote NF‐κB nuclear translocation in cholinergic basal forebrain
Ramesh, V., Thatte, H. S., McCarley, R. W., & Basheer, R. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04314.x · Cited by 55 · see citing works
Electroencephalogram asymmetry and spectral power during sleep in the northern fur seal
Lyamin, O. I., Lapierre, J. L., Kosenko, P. O., Mukhametov, L. M., & Siegel, J. M. (2008) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2008.00639.x · Cited by 52 · see citing works
Brandt, J. A., Churchill, L., Guan, Z., Fang, J., Chen, L., & Krueger, J. M. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02149-7 · Cited by 52 · see citing works
Self-citationClinical experience with soluble TNF p75 receptor in rheumatoid arthritis
Franklin, C. M. (1999) · Seminars in Arthritis and Rheumatism · doi:10.1016/s0049-0172(99)80028-6 · Cited by 49 · see citing works
Yamuy, J., Morales, F. R., & Chase, M. H. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00052-k · Cited by 48 · see citing works
The locus coeruleus and immediate-early genes in spontaneous and forced wakefulness
Tononi, G., Pompeiano, M., & Cirelli, C. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90173-2 · Cited by 46 · see citing works
Kindling Stimuli Delivered at Different Times in the Sleep-Wake Cycle
Yi, P.-L., Tsai, C., Lin, J. S., Lee, C.-C., & Chang, F. (2004) · SLEEP · doi:10.1093/sleep/27.2.203 · Cited by 46 · see citing works
P2 purinergic receptor modulation of cytokine production
Gabel, C. A. (2007) · Purinergic Signalling · doi:10.1007/s11302-006-9034-y · Cited by 45 · see citing works
Yamuy, J., Sampogna, S. L., & Chase, M. H. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02204-6 · Cited by 41 · see citing works
Verderio, C., Bianco, F., Blanchard, M. P., Bergami, M., Canossa, M., Scarfone, E., & Matteoli, M. (2007) · Journal of Neurocytology · doi:10.1007/s11068-007-9011-6 · Cited by 40 · see citing works
Yasuda, K., Churchill, L., Yasuda, T., Blindheim, K., Falter, M., & Krueger, J. M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.11.051 · Cited by 37 · see citing works
Self-citationNerve growth factor enhances sleep in rabbits
Takahashi, S., & Krueger, J. M. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00196-2 · Cited by 36 · see citing works
Self-citationCafeteria feeding induces interleukin-1β mRNA expression in rat liver and brain
Hansen, M. K., Taishi, P., Chen, Z., & Krueger, J. M. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.6.r1734 · Cited by 35 · see citing works
Self-citationState-dependent effects of light-dark cycle on somatosensory and visual cortex EEG in rats
Yasuda, T., Yasuda, K., Brown, R. A., & Krueger, J. M. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00112.2005 · Cited by 34 · see citing works
Self-citationInterhemispheric asymmetry of human sleep EEG in response to selective slow-wave sleep deprivation.
Ferrara, M., Gennaro, L. D., Curcio, G., Cristiani, R., & Bertini, M. (2002) · Behavioral Neuroscience · doi:10.1037//0735-7044.116.6.976 · Cited by 33 · see citing works
Churchill, L., Yasuda, K., Yasuda, T., Blindheim, K., Falter, M., García‐García, F., & Krueger, J. M. (2005) · Brain Research · doi:10.1016/j.brainres.2005.06.052 · Cited by 28 · see citing works
Self-citationGrowth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression
Szentirmai, É., Yasuda, T., Taishi, P., Wang, M., Churchill, L., Bohnet, S. G., Magrath, P., Kacsoh, B. Z., Jimenez, L., & Krueger, J. M. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00237.2007 · Cited by 26 · see citing works
Self-citationSleep EEG dynamics in rat barrel cortex associated with sensory deprivation
Iwasaki, N., Karashima, A., Tamakawa, Y., Katayama, N., & Nakao, M. (2004) · Neuroreport · doi:10.1097/00001756-200412030-00026 · Cited by 19 · see citing works
Interleukin-1 in the central nervous system: from physiology to pathology.
Tringali, G., Russo, C. D., Preziosi, P., & Navarra, P. (2000) · PubMed · Cited by 17 · see citing works
Monocular-unihemispheric sleep and visual discrimination learning in the domestic chick
Mascetti, G. G., Rugger, M., Vallortígara, G., & Bobbo, D. (2006) · Experimental Brain Research · doi:10.1007/s00221-006-0595-3 · Cited by 16 · see citing works
The Effect of Unilateral Somatosensory Stimulation on Hemispheric Asymmetries During Slow Wave Sleep
Cottone, L. A., Adamo, D. S., & Squires, N. K. (2004) · SLEEP · doi:10.1093/sleep/27.1.63 · Cited by 14 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- [32]Krueger JM, Obál F., Jr . Sleep Factors. Sleep and Breathing. New York: Marcel Dekker, Inc.; 1994. pp. 79–112. [Google Scholar]
- [33]Jouvet M. Neuromediateurs et facteurs hypnogenes. Rev Neurol (Paris) 1984;140:389–400. [PubMed] [Google Scholar]
- [34]Inoué S. Biology of sleep substances. Boca Raton, Florida: CRC Press, Inc.; 1989. [Google Scholar]
- [76]Fix C, Churchill L, Hall S, Krueger JM. The number of tumor necrosis factor α-immunoreactive cells increases in layer IV of the barrel field in response to whisker deflection in rats. Sleep. 2006;29:A11. [Google Scholar]
Cited by
Sorted by citations
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477 · see citing works
Saper, C. B., Fuller, P. M., Pedersen, N. P., Lu, J., & Scammell, T. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.032 · Cited by 1,404 · see citing works
Besedovsky, L., Lange, T., & Born, J. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-1044-0 · Cited by 1,153 · see citing works
Sleep and inflammation: partners in sickness and in health
Irwin, M. R. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0190-z · Cited by 1,090 · see citing works
Tumor necrosis factor alpha: A link between neuroinflammation and excitotoxicity
Olmos, G., & Lladó, J. (2014) · Mediators of Inflammation · doi:10.1155/2014/861231 · Cited by 730 · see citing works
The Role of Markers of Inflammation in Traumatic Brain Injury
Woodcock, T. M., & Morganti-Kossmann, M. C. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00018 · Cited by 719 · see citing works
Lopresti, A. L., Hood, S. D., & Drummond, P. D. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.01.014 · Cited by 682 · see citing works
Sleep health: Reciprocal regulation of sleep and innate immunity
Irwin, M. R., & Opp, M. R. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.148 · Cited by 624 · see citing works
Circadian Rhythms and Metabolic Syndrome
Maury, E., Ramsey, K. M., & Bass, J. T. (2010) · Circulation Research · doi:10.1161/circresaha.109.208355 · Cited by 502 · see citing works
Sleep, circadian rhythm, and gut microbiota
Matenchuk, B. A., Mandhane, P. J., & Kozyrskyj, A. L. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101340 · Cited by 495 · see citing works
The Meningeal Lymphatic System: A New Player in Neurophysiology
Da Mesquita, S., Fu, Z., & Kipnis, J. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.022 · Cited by 479 · see citing works
Targeting Tumor Necrosis Factor Alpha for Alzheimer’s Disease
Decourt, B., Lahiri, D. K., & Sabbagh, M. N. (2016) · Current Alzheimer Research · doi:10.2174/1567205013666160930110551 · Cited by 373 · see citing works
TNFα Controls Glutamatergic Gliotransmission in the Hippocampal Dentate Gyrus
Santello, M., Bezzi, P., & Volterra, A. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.003 · Cited by 362 · see citing works
Obstructive Sleep Apnea and Inflammation: Proof of Concept Based on Two Illustrative Cytokines
Gozal, D., & Gozal, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030459 · Cited by 343 · see citing works
Functions and Mechanisms of Sleep
Zielinski, M. R., McKenna, J. T., & McCarley, R. W. (2016) · AIMS neuroscience · doi:10.3934/neuroscience.2016.1.67 · Cited by 347 · see citing works
Crosstalk between the circadian clock circuitry and the immune system
Cermakian, N., Lange, T., Golombek, D., Sarkar, D., Nakao, A., Shibata, S., & Mazzoccoli, G. (2013) · Chronobiology International · doi:10.3109/07420528.2013.782315 · Cited by 279 · see citing works
Neuronal regulation of immunity: why, how and where?
Schiller, M., Ben-Shaanan, T. L., & Rolls, A. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0387-1 · Cited by 267 · see citing works
TNFα in synaptic function: switching gears
Santello, M., & Volterra, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.06.001 · Cited by 245 · see citing works
The role of cytokines in modulating learning and memory and brain plasticity
Bourgognon, J.-M., & Cavanagh, J. (2020) · Brain and Neuroscience Advances · doi:10.1177/2398212820979802 · Cited by 247 · see citing works
Unraveling the evolutionary determinants of sleep
Joiner, W. J. (2016) · Current Biology · doi:10.1016/j.cub.2016.08.068 · Cited by 232 · see citing works
Liu, X., Nemeth, D. P., McKim, D. B., Zhu, L., DiSabato, D. J., Berdysz, O., Gorantla, G., Oliver, B., Witcher, K. G., Wang, Y., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.012 · Cited by 218 · see citing works
AASLD Practice Guidance: Palliative care and symptom‐based management in decompensated cirrhosis
Rogal, S. S., Hansen, L., Patel, A., Ufere, N. N., Verma, M., Woodrell, C. D., & Kanwal, F. (2022) · Hepatology · doi:10.1002/hep.32378 · Cited by 226 · see citing works
Molecular links between endocrine, nervous and immune system during chronic stress
Zefferino, R., Di Gioia, S., & Conese, M. (2021) · Brain and Behavior · doi:10.1002/brb3.1960 · Cited by 204 · see citing works
Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury.
Helmy, A., Simoni, M. D., Guilfoyle, M., Carpenter, K., & Hutchinson, P. (2011) · Progress in neurobiology · doi:10.1016/j.pneurobio.2011.09.003 · Cited by 208 · see citing works
Inflammatory cytokine-associated depression
Lotrich, F. E. (2015) · Brain Research · doi:10.1016/j.brainres.2014.06.032 · Cited by 183 · see citing works
The Role of Inflammatory Cytokines in Cognition and Other Non-Motor Symptoms of Parkinson's Disease
Menza, M. A., Dobkin, R. D., Marín, H., Mark, M. H., Gara, M. A., Bienfait, K., Dicke, A., & Kusnekov, A. (2010) · Psychosomatics · doi:10.1016/s0033-3182(10)70739-8 · Cited by 182 · see citing works
Circadian Regulation of ATP Release in Astrocytes
Marpegán, L., Swanstrom, A. E., Chung, K., Simon, T., Haydon, P. G., Khan, S. K., Liu, A. C., Herzog, E. D., & Beaulé, C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6537-10.2011 · Cited by 177 · see citing works
Ramesh, V., Nair, D., Zhang, S. X. L., Hakim, F., Kaushal, N., Kayali, F. M., Wang, Y., Li, R. C., Carreras, A., & Gozal, D. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-91 · Cited by 166 · see citing works
Sleep, its regulation and possible mechanisms of sleep disturbances
Porkka‐Heiskanen, T., Zitting, K. ‐., & Wigren, H. ‐. (2013) · Acta Physiologica · doi:10.1111/apha.12134 · Cited by 157 · see citing works
Biochemical Regulation of Sleep and Sleep Biomarkers
Clinton, J. M., Davis, C. J., Zielinski, M. R., Jewett, K. A., & Krueger, J. M. (2011) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.1360 · Cited by 159 · see citing works
Self-citationPostoperative sleep disorders and their potential impacts on surgical outcomes
Rampes, S., Ma, K., Divecha, Y. A., Alam, A., & Ma, D. (2020) · Journal of Biomedical Research · doi:10.7555/jbr.33.20190054 · Cited by 155 · see citing works
Krueger, J. M. (2010) · Frontiers in Bioscience-Scholar · doi:10.2741/s176 · Cited by 156 · see citing works
Self-citationEvidence for Neuroinflammatory and Microglial Changes in the Cerebral Response to Sleep Loss
Wisor, J. P., Schmidt, M. A., & Clegern, W. C. (2011) · Sleep · doi:10.1093/sleep/34.3.261 · Cited by 141 · see citing works
Yoshida, T., Shiroshima, T., Lee, S.-J., Yasumura, M., Uemura, T., Chen, X., Iwakura, Y., & Mishina, M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4637-11.2012 · Cited by 134 · see citing works
The Effects of Caffeine on Sleep inDrosophilaRequire PKA Activity, But Not the Adenosine Receptor
Wu, M. N., Ho, K. S., Crocker, A. J., Yue, Z., Koh, K., & Sehgal, A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1653-09.2009 · Cited by 130 · see citing works
Sleep Measures and Morning Plasma TNF-α Levels in Children with Sleep-Disordered Breathing
Gozal, D., Serpero, L. D., Gozal, D., Capdevila, S. O., Khalyfa, A., & Tauman, R. (2010) · SLEEP · doi:10.1093/sleep/33.3.319 · Cited by 127 · see citing works
Involvement of cytokines in slow wave sleep
Krueger, J. M., Clinton, J. M., Winters, B. D., Zielinski, M. R., Taishi, P., Jewett, K. A., & Davis, C. J. (2011) · Progress in Brain Research · doi:10.1016/b978-0-444-53839-0.00003-x · Cited by 126 · see citing works
Self-citationSleep Loss as a Factor to Induce Cellular and Molecular Inflammatory Variations
Hurtado‐Alvarado, G., Pavón, L., Castillo-García, S. A., Hernández, M. E., Domı́nguez-Salazar, E., Velázquez‐Moctezuma, J., & Gómez‐González, B. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/801341 · Cited by 128 · see citing works
Interoception and Inflammation in Psychiatric Disorders
Savitz, J., & Harrison, N. A. (2018) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.12.011 · Cited by 126 · see citing works
Fatigue in Inflammatory Bowel Diseases: Etiologies and Management
Nocerino, A., Nguyen, A., Agrawal, M., Mone, A., Lakhani, K., & Swaminath, A. (2020) · Advances in Therapy · doi:10.1007/s12325-019-01151-w · Cited by 126 · see citing works
Randomized, Controlled Trial of Exercise on Objective and Subjective Sleep in Parkinson's Disease
Amara, A. W., Wood, K. H., Joop, A., Memon, R. A., Pilkington, J., Tuggle, S. C., Reams, J., Barrett, M. J., Edwards, D. A., WELTMAN, A. L., et al. (2020) · Movement Disorders · doi:10.1002/mds.28009 · Cited by 123 · see citing works
Morris, G., Stubbs, B., Köhler, C. A., Walder, K. R., Slyepchenko, A., Berk, M., & Carvalho, A. F. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.03.007 · Cited by 122 · see citing works
Sleep and immunity: A growing field with clinical impact
Opp, M. R., & Krueger, J. M. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.03.011 · Cited by 119 · see citing works
Self-citationErasing Synapses in Sleep: Is It Time to Be SHY?
Frank, M. G. (2012) · Neural Plasticity · doi:10.1155/2012/264378 · Cited by 117 · see citing works
Kincheski, G. C., Valentim, I. S., Clarke, J. R., Cozachenco, D., Castelo-Branco, M. T. L., Ramos-Lobo, A. M., Rumjanek, V. M. B. D., Donato, J., De Felice, F. G., & Ferreira, S. T. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.04.007 · Cited by 117 · see citing works
Microglia regulate sleep through calcium-dependent modulation of norepinephrine transmission
Ma, C., Li, B., Silverman, D., Ding, X., Li, A., Xiao, C., Huang, G., Worden, K., Muroy, S. E., Chen, W., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-023-01548-5 · Cited by 122 · see citing works
The interplay between sleep and gut microbiota
Han, M., Yuan, S., & Zhang, J. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.12.016 · Cited by 120 · see citing works
Neuroimaging, cognition, light and circadian rhythms
Gaggioni, G., Maquet, P., Schmidt, C., Dijk, D., & Vandewalle, G. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00126 · Cited by 113 · see citing works
Moderate exercise training modulates cytokine profile and sleep in elderly people
dos Santos, R. V. T., Viana, V. A. R., Boscolo, R. A., Marques, V. G., Santana, M. G., Lira, F. S., Tufik, S., & de Mello, M. T. (2012) · Cytokine · doi:10.1016/j.cyto.2012.07.028 · Cited by 112 · see citing works
Sapin, E., Peyron, C., Roche, F., Gay, N., Carcenac, C., Savasta, M., Levy, P. A., & Demattéis, M. (2015) · SLEEP · doi:10.5665/sleep.5042 · Cited by 112 · see citing works
Experimental Pain and Opioid Analgesia in Volunteers at High Risk for Obstructive Sleep Apnea
Doufas, A. G., Tian, L., Padrez, K., Suwanprathes, P., Cardell, J. A., Maecker, H. T., & Panousis, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054807 · Cited by 110 · see citing works
Delta Wave Power: An Independent Sleep Phenotype or Epiphenomenon?
Davis, C. J., Clinton, J. M., Jewett, K. A., Zielinski, M. R., & Krueger, J. M. (2011) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.1346 · Cited by 106 · see citing works
Self-citationTNF-α Gene Polymorphisms and Excessive Daytime Sleepiness in Pediatric Obstructive Sleep Apnea
Khalyfa, A., Serpero, L. D., Gozal, D., Capdevila, Ó. S., & Gozal, D. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.07.032 · Cited by 102 · see citing works
Depression in Autoimmune Diseases
Pryce, C. R., & Fontana, A. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_7 · Cited by 100 · see citing works
Li, Y., Zhang, S., Zhu, J., Du, X.-N., & Huang, F. (2012) · Arthritis Research & Therapy · doi:10.1186/ar4054 · Cited by 100 · see citing works
Sleep disorders and systemic lupus erythematosus
Palagini, L., Tani, C., Mauri, M. F., Carli, L., Vagnani, S., Bombardieri, S., Gemignani, A., & Mosca, M. (2014) · Lupus · doi:10.1177/0961203313518623 · Cited by 101 · see citing works
Sleep: a synchrony of cell activity‐driven small network states
Krueger, J. M., Huang, Y. H., Rector, D. M., & Buysse, D. J. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12238 · Cited by 95 · see citing works
Self-citationRegulation of zebrafish sleep and arousal states: current and prospective approaches
Chiu, C. N., & Prober, D. A. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00058 · Cited by 95 · see citing works
Zielinski, M. R., Dunbrasky, D. L., Taishi, P., Souza, G., & Krueger, J. M. (2013) · Sleep · doi:10.5665/sleep.2892 · Cited by 94 · see citing works
Self-citationHumoral Sleep Regulation; Interleukin-1 and Tumor Necrosis Factor
Jewett, K. A., & Krueger, J. M. (2012) · Vitamins and hormones · doi:10.1016/b978-0-12-394623-2.00013-5 · Cited by 91 · see citing works
Self-citationExercise training improves sleep quality: A randomized controlled trial
Jurado‐Fasoli, L., De‐la‐O, A., Molina‐Hidalgo, C., Migueles, J. H., Castillo, M. J., & Amaro‐Gahete, F. J. (2020) · European Journal of Clinical Investigation · doi:10.1111/eci.13202 · Cited by 91 · see citing works
Chronic rhinosinusitis and sleep: a contemporary review
Alt, J. A., & Smith, T. L. (2013) · International Forum of Allergy & Rhinology · doi:10.1002/alr.21217 · Cited by 90 · see citing works
Dean, B. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001410 · Cited by 89 · see citing works
Kranjac, D., McLinden, K. A., Deodati, L. E., Papini, M. R., Chumley, M. J., & Boehm, G. W. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.08.005 · Cited by 88 · see citing works
Sterile Neuroinflammation and Strategies for Therapeutic Intervention
Banjara, M., & Ghosh, C. (2017) · International Journal of Inflammation · doi:10.1155/2017/8385961 · Cited by 87 · see citing works
Milrad, S. F., Hall, D. L., Jutagir, D. R., Lattie, E. G., Ironson, G. H., Wohlgemuth, W. K., Vera-Nunez, M. A., Garcia, L., Czaja, S. J., Perdomo, D. M., et al. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.12.008 · Cited by 89 · see citing works
Inflammatory pathways in children with insufficient or disordered sleep
Kim, J., Hakim, F., Gozal, D., & Gozal, D. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.04.024 · Cited by 88 · see citing works
TNF-α and Temporal Changes in Sleep Architecture in Mice Exposed to Sleep Fragmentation
Kaushal, N., Ramesh, V., & Gozal, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045610 · Cited by 90 · see citing works
Weinberger, J. F., Raison, C. L., Rye, D. B., Montague, A. R., Woolwine, B. J., Felger, J. C., Haroon, E., & Miller, A. H. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.12.016 · Cited by 86 · see citing works
Rheumatic manifestations of sleep disorders
Moldofsky, H. (2009) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328333b9cc · Cited by 83 · see citing works
Short natural sleep is associated with higher T cell and lower NK cell activities
Fondell, E., Axelsson, J., Franck, K. T., Ploner, A., Lekander, M., Bälter, K. A., & Gaines, H. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.04.004 · Cited by 82 · see citing works
Wadhwa, M., Prabhakar, A., Anand, J. P., Ray, K., Prasad, D. N., Kumar, B., & Panjwani, U. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.08.004 · Cited by 82 · see citing works
RetractedNitter, A. K., Pripp, A. H., & Forseth, K. Ø. (2012) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2012.04.001 · Cited by 81 · see citing works
Circadian rhythmicity of pain sensitivity in humans
Daguet, I., Raverot, V., Bouhassira, D., & Gronfier, C. (2022) · Brain · doi:10.1093/brain/awac147 · Cited by 81 · see citing works
Diffuse Brain Injury Induces Acute Post-Traumatic Sleep
Rowe, R. K., Striz, M., Bachstetter, A., Eldik, L. V. V., Donohue, K., O'Hara, B., & Lifshitz, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0082507 · Cited by 84 · see citing works
Aerobic exercise modulates cytokine profile and sleep quality in elderly
El-Kader, S. M. A., & Al-Jiffri, O. H. (2019) · African Health Sciences · doi:10.4314/ahs.v19i2.45 · Cited by 78 · see citing works
Neuropeptidergic control of sleep and wakefulness
Richter, C., Woods, I. G., & Schier, A. F. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150447 · Cited by 75 · see citing works
Zhao, F.-Y., Spencer, S. J., Kennedy, G. A., Zheng, Z., Conduit, R., Zhang, W., Xu, P., Yue, L.-P., Wang, Y.-M., Xu, Y., et al. (2023) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2023.101892 · Cited by 76 · see citing works
Astrocyte‐derived adenosine modulates increased sleep pressure during inflammatory response
Nadjar, A., Blutstein, T., Aubert, A., Layé, S., & Haydon, P. G. (2013) · Glia · doi:10.1002/glia.22465 · Cited by 76 · see citing works
Charalambous, A., Berger, A. M., Matthews, E. E., Balachandran, D. D., Papastavrou, E., & Palesh, O. G. (2019) · Supportive Care in Cancer · doi:10.1007/s00520-019-04746-9 · Cited by 75 · see citing works
Sleep, immunity and shift workers: A review
de Almeida, C. M. O., & Malheiro, A. (2016) · Sleep Science · doi:10.1016/j.slsci.2016.10.007 · Cited by 76 · see citing works
Sleep and Inflammatory Bowel Disease: An Important Bi-Directional Relationship
Qazi, T., & Farraye, F. A. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy334 · Cited by 75 · see citing works
Neuroinflammation in psychiatric disorders: An introductory primer
Dunn, G. A., Loftis, J. M., & Sullivan, E. L. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172981 · Cited by 73 · see citing works
The RFamide receptor DMSR-1 regulates stress-induced sleep in C. elegans
Iannacone, M. J., Beets, I., Lopes, L. E., Churgin, M. A., Fang-Yen, C. M., Nelson, M. D., Schoofs, L., & Raizen, D. M. (2017) · eLife · doi:10.7554/elife.19837 · Cited by 69 · see citing works
Mammalian Sleep Dynamics: How Diverse Features Arise from a Common Physiological Framework
Phillips, A. J. K., Robinson, P. A., Kedziora, D. J., & Abeysuriya, R. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000826 · Cited by 70 · see citing works
Astroglial regulation of sleep homeostasis
Frank, M. G. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.02.009 · Cited by 68 · see citing works
Cameron, S., Donnelly, A., Broderick, C., Arichi, T., Bartsch, U., Dazzan, P., Elberling, J., Godfrey, E. L., Gringras, P., Heathcote, L. C., et al. (2023) · Allergy · doi:10.1111/all.15818 · Cited by 72 · see citing works
A meta-analysis on sleep quality in inflammatory bowel disease
Ballesio, A., Zagaria, A., Baccini, F., Micheli, F., Nardo, G. D., & Lombardo, C. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101518 · Cited by 67 · see citing works
Role of cytokines in atypical depression
Yoon, H.-K., Kim, Y.-K., Lee, H.-J., Kwon, D.-Y., & Kim, L. (2012) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2011.611894 · Cited by 65 · see citing works
Walker, A., McKune, A. J., Ferguson, S. A., Pyne, D. B., & Rattray, B. (2016) · Extreme Physiology & Medicine · doi:10.1186/s13728-016-0049-x · Cited by 68 · see citing works
Human immune system during sleep.
Asif, N., Iqbal, R., & Chaudhry, F. N. (2017) · PubMed Central · Cited by 64 · see citing works
Green, T. R. F., Ortiz, J. B., Wonnacott, S., Williams, R. J., & Rowe, R. K. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00894 · Cited by 63 · see citing works
Chang, J.-H., Huang, P.-T., Lin, Y., Lin, C., Lin, C.-M., Shieh, Y., & Lin, Y. (2015) · International Journal of Occupational Medicine and Environmental Health · doi:10.13075/ijomeh.1896.00359 · Cited by 65 · see citing works
Ebola: translational science considerations
Chiappelli, F., Bakhordarian, A., Thames, A. D., Du, A. M., Jan, A. L., Nahcivan, M., Nguyen, M. T., Sama, N., Manfrini, E., Piva, F., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-014-0362-3 · Cited by 61 · see citing works
Radiation-Induced Neuroinflammation and Radiation Somnolence Syndrome
Ballesteros‐Zebadúa, P., Chavarría, A., Celis, M. A., Paz, C., & Franco‐Pérez, J. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311201070937 · Cited by 59 · see citing works
González‐Guevara, E., Martínez‐Lazcano, J. C., Custodio, V., Hernández‐Cerón, M., Rubio, C., & Paz, C. (2014) · Inhalation Toxicology · doi:10.3109/08958378.2014.922648 · Cited by 60 · see citing works
Rowe, R. K., Harrison, J., O'Hara, B., & Lifshitz, J. (2014) · Sleep · doi:10.5665/sleep.3582 · Cited by 62 · see citing works
Sleep disturbances in HIV infection and their biological basis
O'Brien, K. E., Riddell, N. E., Gómez-Olivé, F. X., Rae, D. E., Scheuermaier, K. D., & von Schantz, M. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101571 · Cited by 58 · see citing works
Genotype–phenotype interactions in pediatric obstructive sleep apnea
Gozal, D., & Gozal, D. (2013) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2013.03.016 · Cited by 57 · see citing works
Role of Glia in the Regulation of Sleep in Health and Disease
Garofalo, S., Picard, K., Limatola, C., Nadjar, A., Pascual, O., & Tremblay, M. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190022 · Cited by 63 · see citing works
- Authors
- Krueger, J.
- Affiliations
- Washington State University (US)
- Corresponding author
- Krueger, James
- Venue
- Current Pharmaceutical Design
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2008-11-01
- Volume
- 14
- Issue
- 32
- Pages
- 3408-3416
- ISSN
- 1381-6128 (ISSN-L)
- PMC
- PMC2692603
- OpenAlex
- W2023517019
- Cited by
- 507
- References
- 114
- Citations by year
- 2026: 18 · 2025: 42 · 2024: 43 · 2023: 32 · 2022: 28 · 2021: 32 · 2020: 30 · 2019: 33 · 2018: 19 · 2017: 23 · 2016: 27 · 2015: 19 · 2014: 31 · 2013: 52 · 2012: 26
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Pharmaceutical Design (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-31453, NS-25378, R01NS031453, R01NS027250, R01NS025378)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-36520, R01HD036520)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- cytokines, sleep regulation, IL-1β, TNF-α, NREM sleep, ATP release, purinergic P2 receptors, glial activation, sleep deprivation, cortical columns, cortical oscillations, nitric oxide, prostaglandins, adenosine
- MeSH terms
- Humans, Sleep, Cytokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
