The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.
The effect of Centella Asiatica cream on scar development in patients who underwent open carpal tunnel release surgery
Abstract
Aim To evaluate the efficacy of the Centella asiatica extract in a cream preparation for the prevention of scar tenderness formation in patients who underwent conventional open carpal tunnel release (CTR) surgery. Material and methods A total of 280 patients with carpal tunnel syndrome who underwent CTR surgery were individually randomized into the intervention (n = 140) and control (n = 140) groups. In the intervention group, a petroleum cream mixture consisting of 1% Centella asiatica extract was applied to the patients' wrist for 6 months after the sutures were removed. In the control group, no intervention was applied. The Vancouver Scar Scale (VSS), Quick Disabilities of Arm, Shoulder and Hand (QuickDASH) functional score, and Visual Analog Scale (VAS) satisfaction scores were assessed preoperatively and postoperatively. Follow-up evaluations were scheduled at 1, 3 and 6 months after CTR surgery. Results The overall VSS score of the intervention group significantly improved at 3-6 months (-1.260, p = .040). At 6 months after surgery, the mean QuickDASH functional score was 18.54 (range 0.00-63.64, SD 17.4) in the intervention group and 28.70 ± 12 (range: 2.27-40.91) in the control group (p Conclusion The Centella asiatica cream applied to the wrist after CTR surgery was found to be beneficial in preventing scar tenderness in the thenar and hypothenar regions of the hand.
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“In murine scar models, treatment with C. asiatica extracts has been shown to downregulate transforming growth factor beta 1 (TGF-β1) expression, decrease collagen I and III synthesis, and reduce overall scar thickness (Balevi and Balevi 2023).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Balevi and Balevi 2023
In the citing paper
“A randomized controlled trial (RCT) involving 280 postoperative carpal tunnel release patients demonstrated that twice-daily topical application of a 1% C. asiatica cream significantly improved scar outcomes as measured by the Vancouver Scar Scale (VSS); the mean VSS score was reduced by 2.1 points in the treatment group versus 0.8 in the control group after 8 weeks (p < 0.01), with reduced”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Balevi and Balevi 2023
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Cites
The Vancouver Scar Scale: An Administration Tool and Its Interrater Reliability
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The Roles of Inflammation in Keloid and Hypertrophic Scars
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Incidence of common compressive neuropathies in primary care
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Centella asiatica in Dermatology: An Overview
Bylka, W., Znajdek-Awiżeń, P., Studzińska-Sroka, E., Dańczak‐Pazdrowska, A., & Brzezińska, M. (2014) · Phytotherapy Research · doi:10.1002/ptr.5110 · Cited by 231
Centella asiatica in cosmetology
Bylka, W., Znajdek-Awiżeń, P., Studzińska-Sroka, E., & Brzezińska, M. (2013) · Advances in Dermatology and Allergology · doi:10.5114/pdia.2013.33378 · Cited by 229
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Handayani, R., Febriyanti, R. M., Muhaimin, M., & Chearunisaa, A. Y. (2025) · Pharmacia · doi:10.3897/pharmacia.72.e167217 · Cited by 5
Biological activity and mechanism of action of Gotu kola oil in skin wound repair
Xu, B., Duan, Y., Yu, D., & Jia, P. (2024) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v23i4.3 · Cited by 2
Assessment of the Medicinal Flora for Treating Skin Disorders in Indonesia
Astuti, I. P., Cahyaningsih, R., Hidayat, S., Juhaeti, T., Husaini, I. P. A., Suhaendah, E., Garvita, R. V., Maharani, D., Wawangningrum, H., Solihah, S. M., et al. (2024) · Springer eBooks · doi:10.1007/978-981-97-2367-6_2
Suraya, L., & Ashraf, K. (2026) · International Journal of Pharmaceuticals Nutraceuticals and Cosmetic Science · doi:10.24191/ijpnacs.v9i1.09
tambunan, G. C. A., Girsang, E., & Nasution, A. N. (2023) · Health Information Jurnal Penelitian
Metadata
- Authors
- Balevi, M., & Balevi, A.
- Affiliations
- Konya Numune Hastanesi (TR)
- Istanbul Medipol University (TR)
- Corresponding author
- Balevi, Mustafa
- Venue
- Journal of Hand Therapy
- Publisher
- Elsevier BV
- Published
- 2023-10
- Volume
- 36
- Issue
- 4
- Pages
- 962-966
- ISSN
- 0894-1130 (ISSN-L)
- OpenAlex
- W4323979968
- Cited by
- 3
- References
- 39
- Citations by year
- 2025: 1 · 2024: 2
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Hand Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Health Sciences › Medicine › Surgery › Orthopedic Surgery and Rehabilitation
- Health Sciences › Medicine › Clinical Neurology › Peripheral Nerve Disorders
- Keywords
- Centella asiatica, scar tenderness, carpal tunnel release, carpal tunnel syndrome, topical cream, Vancouver Scar Scale, QuickDASH, patient satisfaction
- MeSH terms
- Carpal Tunnel Syndrome, Cicatrix, Humans, Plant Extracts, Triterpenes, Treatment Outcome, Centella
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