Antioxidant activity of flavonoid compounds isolated from the petals of Hibiscus rosa sinensis
Open accessAbstract
Hibiscus rosasinensis , medicinal plant known for its various medicinal properties. The present study was to identify and characterize the flavonoid compound from the petals of Hibiscus rosa sinensis . The antioxidant compounds were isolated by Silica Gel G Column chromatography. From the fractions, C5 shows the highest antioxidant activity compared to C3 & C4 compounds. DNA damage protection activity results indicated that two major bands super coiled DNA and open circular DNA was protected by the presence of different concentration (5 µg, 10 µg, 15 µg & 20 µg) of C5 compound isolated from the petals of Hibiscus rosa sinensis. IR absorptions peaks reveals the presence of functional groups alcohols, phenols, α,β unsaturated aldehyes, ketones and alkanes. The structure of compound was characterized as Hibiscetin-3-glucoside (C 21 H 20 O 14 ) by Mass spectroscopy and NMR. The study emphasized flavanoid compounds have effective scavenging activities which may be due to its phenolics and flavonoid contents and can be used as anticancer agents.
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Hibiscus rosa-sinensis increases AChE expression.
“increased”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [169]
Hibiscus rosa-sinensis reverses scopolamine-induced decrease in ChAT expression.
“Reversed the”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [169]
Hibiscus rosa-sinensis decreases ACh.
“decreased ACh”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [169]
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- Authors
- Rengarajan, S., Melanathuru, V., Govindasamy, C., Chinnadurai, V., & Elsadek, M. F.
- Affiliations
- Dr. M.G.R. Educational and Research Institute (IN)
- King Saud University (SA)
- Corresponding author
- Melanathuru, Vijayalakshmi
- Venue
- Journal of King Saud University - Science
- Publisher
- Scientific Scholar
- Published
- 2020-04
- Volume
- 32
- Issue
- 3
- Pages
- 2236-2242
- ISSN
- 1018-3647 (ISSN-L)
- OpenAlex
- W3010075342
- Cited by
- 40
- References
- 23
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 4 · 2023: 10 · 2022: 6 · 2021: 8
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of King Saud University - Science (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Deanship of Scientific Research at King Saud University (RG-1437-024)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Hibiscus Plant Research Studies
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Agricultural Practices and Plant Genetics
- Keywords
- Hibiscus rosa-sinensis, flavonoids, antioxidant activity, petal extract, DNA damage protection, free radical scavenging, anticancer agents, phenolic compounds, structure elucidation
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