The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
Mechanisms of Selective Autophagy
Open accessAbstract
Selective autophagy contributes to intracellular homeostasis by mediating the degradation of cytoplasmic material such as aggregated proteins, damaged or over-abundant organelles, and invading pathogens. The molecular machinery for selective autophagy must ensure efficient recognition and sequestration of the cargo within autophagosomes. Cargo specificity can be mediated by autophagic cargo receptors that specifically bind the cargo material and the autophagosomal membrane. Here we review the recent insights into the mechanisms that enable cargo receptors to confer selectivity and exclusivity to the autophagic process. We also discuss their different roles during starvation-induced and selective autophagy. We propose to classify autophagic events into cargo-independent and cargo-induced autophagosome formation events.
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Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
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Autophagy in the Pathogenesis of Disease
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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
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“Cargo receptors bind to ATG8-family proteins via a conserved LC3-Interacting Region (LIR) motif, also known as Atg8-Interacting Motif (AIM) [46,81].”
Autophagy and Viruses: Adversaries or Allies?
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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
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Cited by
Swatek, K. N., & Komander, D. (2016) · Cell Research · doi:10.1038/cr.2016.39 · Cited by 2,081
Molecular definitions of autophagy and related processes
Galluzzi, L., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cecconi, F., Choi, A. M., Chu, C. T., Codogno, P., Colombo, M. I., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201796697 · Cited by 1,646
Self-citationAUTACs: Cargo-Specific Degraders Using Selective Autophagy
Takahashi, D., Moriyama, J., Nakamura, T., Miki, E., Takahashi, E., Sato, A., Akaike, T., Itto-Nakama, K., & Arimoto, H. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.09.009 · Cited by 675
Mechanisms of Autophagy Initiation
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Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease
Reddy, P. H., & Oliver, D. M. (2019) · Cells · doi:10.3390/cells8050488 · Cited by 496
“The cargo receptor proteins recognize poly-ubiquitin chains on the surface of the targeted cargo, which triggers selective autophagy [83].”
BackgroundInfluential
Metadata
- Authors
- Zaffagnini, G., & Martens, S.
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 428
- Issue
- 9
- Pages
- 1714-1724
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W2262858406
- Cited by
- 600
- References
- 121
- FWCI
- 44.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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