The DOI matches its Crossref record; 92 of the 93 references it cites were found in a registry or an index.
Aerobic exercise and lipids and lipoproteins in men: a meta-analysis of randomized controlled trials
Open accessAbstract
BACKGROUND: Aerobic exercise is recommended for improving lipoprotein and lipid levels which at less than their optimal levels are risk factors for cardiovascular disease. Evidence seems lacking for the effectiveness of exercise in reducing these levels, possibly due to small sizes in studies. We concluded a meta-analysis of the studies to examine the effects of aerobic exercise on lipids and lipoproteins in adult men. METHODS: Studies were retrieved via computerized literature searches, cross-referencing from retrieved articles, hand-searching, and expert review of our reference list. Inclusion criteria were randomized controlled trials, aerobic exercise ≥8 weeks, adult men ≥18 years of age, studies published in journal, dissertation, or master's thesis format, studies published in the English-language between January 1, 1955 and January 1, 2003, and assessment of one or more of the following lipids and lipoproteins: total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDLC), and triglycerides (TG). All coding was conducted by both authors, independent of each other. Discrepancies were resolved by consensus. RESULTS: Forty-nine randomized controlled trials representing up to 67 outcomes from 2,990 men (1,741 exercise, 1,249 control) were pooled for analysis. Using random-effects modeling, statistically significant improvements were observed for TC, HDL-C and TG, and a trend for decreases was observed for LDL-C. Changes were equivalent to improvements of 2% for TC and HDL-C, 3% of LDL-C, and 9% for TG. CONCLUSIONS: Aerobic exercise reduces TC and TG and increases HDL-C in men 18 years of age and older.
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“Aerobic exercise is effective in improving lipid metabolism607–615).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [612]
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“Six reported a significant increase in HDL-C levels, which was the most frequently observed effect of exercise on serum lipids577, 607–613).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [612]
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“A meta-analysis of 25 RCTs that compared aerobic exercise for training periods of at least 15 minutes for ≥ 8 weeks with nonexercise control reported that exercise therapy significantly increased the HDL-C levels612).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [612]
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Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813
Okamura, T., Tsukamoto, K., Arai, H., Fujioka, Y., Ishigaki, Y., Koba, S., Ohmura, H., Shoji, T., Yokote, K., Yoshida, H., et al. (2023) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2022 · Cited by 345
Pattyn, N., Cornelissen, V. A., Eshghi, S. R. T., & Vanhees, L. (2013) · Sports Medicine · doi:10.1007/s40279-012-0003-z · Cited by 266
Kelley, G. A., & Kelley, K. S. (2009) · Preventive Medicine · doi:10.1016/j.ypmed.2008.10.010 · Cited by 263
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Metadata
- Authors
- Kelley, G. A., & Kelley, K. S.
- Affiliations
- West Virginia University (US)
- Venue
- The Journal of Men's Health & Gender
- Publisher
- SAGE Publications
- Published
- 2006-03
- Volume
- 3
- Issue
- 1
- Pages
- 61-70
- ISSN
- 1571-8913 (ISSN-L)
- PMC
- PMC2475654
- OpenAlex
- W2045752222
- Cited by
- 127
- References
- 93
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 8 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 9 · 2018: 9 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 10 · 2013: 8 · 2012: 5
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Men s Health and Gender (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL069802)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- aerobic exercise, lipids, lipoproteins, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, cardiovascular risk, men, exercise intervention
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