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Cited by 19Neuroscience and Neural EngineeringCellular Mechanics and InteractionsNeuroinflammation and Neurodegeneration Mechanisms

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Examining the inflammatory response to nanopatterned polydimethylsiloxane using organotypic brain slice methods

Ereifej, Evon S., Cheng, Mark Ming-Cheng, Mao, Guangzhao, VandeVord, Pamela J.·2013·Journal of Neuroscience Methods
DOI 10.1016/j.jneumeth.2013.04.023
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Abstract

A long-term effect of chronically implanted neural electrodes is the formation of a glial scar made up of reactive astrocytes, microglia and the matrix proteins they generate. Studies have shown glial fibrillary acidic protein (GFAP) and cytokines interleukin-1beta (IL-1β), tumor necrosis factor alpha (TNFα), and transforming growth factor beta 1 (TGFβ1) are involved with the initial and modulation phases of reactive astrogliosis. In the present study, nanopatterning of polydimethylsiloxane (PDMS) was attempted as a method for reducing the inflammatory response of glial cells. A unique feature of this study is the use of in vitro brain slice cultures (organotypic cultures) in order to more accurately depict the native response. The aim of the study was to determine whether nanotopography could reduce inflammatory signals typically resultant from neural electrode implantation. Specifically, observation of cell alignment and surveillance of GFAP, IL-1β, TNFα, and TGFβ1 gene expression around the PDMS pins was performed. Results of this study confirm nanopatterning not only influences cell morphology, but some of the molecular signals as well. These results collectively indicate nanopatterning improves the biocompatibility of PDMS by reducing inflammatory markers such as GFAP, IL-1β, TGFβ1 and TNFα compared to the non-patterned PDMS pins.

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Research works printed but not linked: 65

  1. Berdichevsky, 2009, Microfluidics and multielectrode array-compatible organotypic slice culture method, J Neurosci Methods, 178, 59, 10.1016/j.jneumeth.2008.11.016 · DOI
  2. Berdichevsky, 2010, Building and manipulating neural pathways with microfluidics, Lab Chip, 10, 999, 10.1039/b922365g · DOI
  3. Blattler, 2006, Nanopatterns with biological functions, J Nanosci Nanotechnol, 6, 2237, 10.1166/jnn.2006.501 · DOI
  4. Bruder, 2007, Biomimetic materials replicating Schwann cell topography enhance neuronal adhesion and neurite alignment in vitro, J Biomater Sci Polym Ed, 18, 967, 10.1163/156856207781494412 · DOI
  5. Brunetti, 2010, Neurons sense nanoscale roughness with nanometer sensitivity, Proc Natl Acad Sci USA, 107, 6264, 10.1073/pnas.0914456107 · DOI
  6. Choi, 2009, Hydrophobic nanopatterning on a flexible gas barrier film by using a poly(dimethylsiloxane) elastomer, Nanotechnology, 20, 135303, 10.1088/0957-4484/20/13/135303 · DOI
  7. Chou, 2012, A largely deformable surface type neural electrode array based on PDMS a publication of the IEEE Engineering in Medicine and Biology Society, IEEE Trans Neural Syst Rehabil Eng
  8. Curtis, 2005, The potential for the use of nanofeaturing in medical devices, Expert Rev Med Devices, 2, 293, 10.1586/17434440.2.3.293 · DOI
  9. Curtis, 2004, Cells react to nanoscale order and symmetry in their surroundings, IEEE Trans Nanobiosci, 3, 61, 10.1109/TNB.2004.824276 · DOI
  10. Das, 2008, A microfluidic platform for studying the effects of small temperature gradients in an incubator environment, Biomicrofluidics, 2, 34106, 10.1063/1.2988313 · DOI
  11. David, 1999, Rapid prototyping of microfluidic switches in poly(dimethyl siloxane) and their actuation by electro-osmotic flow, J Micromech Microeng, 9
  12. Davids, 2002, Organotypic rat cerebellar slice culture as a model to analyze the molecular pharmacology of GABAA receptors, Eur Neuropsychopharmacol: J Eur Coll Neuropsychopharmacol, 12, 201, 10.1016/S0924-977X(02)00024-X · DOI
  13. Ding, 2010, Actin-driven cell dynamics probed by Fourier transform light scattering, Biomed Opt Express, 1, 260, 10.1364/BOE.1.000260 · DOI
  14. Dong, 2001, Immune function of astrocytes, Glia, 36, 180, 10.1002/glia.1107 · DOI
  15. Ereifej, 2011, Characterization of astrocyte reactivity and gene expression on biomaterials for neural electrodes, J Biomed Mater Res A, 99, 141, 10.1002/jbm.a.33170 · DOI
  16. Ereifej, 2013, Nanopatterning effects on astrocyte reactivity, J Biomed Mater Res A, 101, 1743, 10.1002/jbm.a.34480 · DOI
  17. Farina, 2007, Astrocytes are active players in cerebral innate immunity, Trends Immunol, 28, 138, 10.1016/j.it.2007.01.005 · DOI · Paper page
  18. Fok-Seang, 1998, Cytokine-induced changes in the ability of astrocytes to support migration of oligodendrocyte precursors and axon growth, Eur J Neurosci, 10, 2400, 10.1046/j.1460-9568.1998.00251.x · DOI
  19. Gervasi, 2008, Role of extracellular factors in axon regeneration in the CNS: implications for therapy, Regen Med, 3, 907, 10.2217/17460751.3.6.907 · DOI
  20. Glass, 2010, Mechanisms underlying inflammation in neurodegeneration, Cell, 140, 918, 10.1016/j.cell.2010.02.016 · DOI · Paper page
  21. Gobbels, 2010, Neuronal cell growth on iridium oxide, Biomaterials, 31, 1055, 10.1016/j.biomaterials.2009.10.029 · DOI
  22. Gomez, 2007, Immobilized nerve growth factor and microtopography have distinct effects on polarization versus axon elongation in hippocampal cells in culture, Biomaterials, 28, 271, 10.1016/j.biomaterials.2006.07.043 · DOI
  23. Gomez, 2007, Nerve growth factor-immobilized polypyrrole: bioactive electrically conducting polymer for enhanced neurite extension, J Biomed Mater Res A, 81, 135, 10.1002/jbm.a.31047 · DOI · Paper page
  24. Makamba, 2003, Surface modification of poly(dimethylsiloxane) microchannels, Electrophoresis, 24, 3607, 10.1002/elps.200305627 · DOI
  25. Hanson, 2009, Textural guidance cues for controlling process outgrowth of mammalian neurons, Lab Chip, 9, 122, 10.1039/B803595D · DOI
  26. Herx, 2001, Interleukin-1 beta is required for the early evolution of reactive astrogliosis following CNS lesion, J Neuropathol Exp Neurol, 60, 961, 10.1093/jnen/60.10.961 · DOI
  27. John, 2003, Cytokines: powerful regulators of glial cell activation, Neuroscientist, 9, 10, 10.1177/1073858402239587 · DOI
  28. Kotov, 2009, Nanomaterials for neural interfaces, Adv Mater, 21, 3970, 10.1002/adma.200801984 · DOI · Paper page
  29. Kotzar, 2002, Evaluation of MEMS materials of construction for implantable medical devices, Biomaterials, 23, 2737, 10.1016/S0142-9612(02)00007-8 · DOI
  30. Kriparamanan, 2006, Nanotopography: cellular responses to nanostructured materials, J Nanosci Nanotechnol, 6, 1905, 10.1166/jnn.2006.330 · DOI
  31. Lacour, 2010, Flexible and stretchable micro-electrodes for in vitro and in vivo neural interfaces, Med Biol Eng Comput, 48, 945, 10.1007/s11517-010-0644-8 · DOI
  32. Liberto, 2004, Pro-regenerative properties of cytokine-activated astrocytes, J Neurochem, 89, 1092, 10.1111/j.1471-4159.2004.02420.x · DOI · Paper page
  33. Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method, Methods, 25, 402, 10.1006/meth.2001.1262 · DOI · Paper page
  34. Logan, 1994, Effects of transforming growth factor beta 1 on scar production in the injured central nervous system of the rat, Eur J Neurosci, 6, 355, 10.1111/j.1460-9568.1994.tb00278.x · DOI
  35. Lotters, 1997, The mechanical properties of the rubber elastic polymer polydimethylsiloxane for sensor applications, J Micromech Microeng, 7, 145, 10.1088/0960-1317/7/3/017 · DOI
  36. Mieszawska, 2010, Smart biomaterials – regulating cell behavior through signaling molecules, BMC Biol, 8, 59, 10.1186/1741-7007-8-59 · DOI
  37. Millet, 2010, Direct cellular peptidomics of supraoptic magnocellular and hippocampal neurons in low-density co-cultures, ACS Chem Neurosci, 1, 36, 10.1021/cn9000022 · DOI
  38. Millet, 2007, Microfluidic devices for culturing primary mammalian neurons at low densities, Lab Chip, 7, 987, 10.1039/b705266a · DOI
  39. Moolwaney, 2005, Regulation of the cyclooxygenase-2 system by interleukin-1beta through mitogen-activated protein kinase signaling pathways: a comparative study of human neuroglioma and neuroblastoma cells, Brain Res Mol Brain Res, 137, 202, 10.1016/j.molbrainres.2005.03.010 · DOI
  40. Morin, 2006, Constraining the connectivity of neuronal networks cultured on microelectrode arrays with microfluidic techniques: a step towards neuron-based functional chips, Biosens Bioelectron, 21, 1093, 10.1016/j.bios.2005.04.020 · DOI
  41. Negi, 2010, In vitro comparison of sputtered iridium oxide and platinum-coated neural implantable microelectrode arrays, Biomed Mater, 5, 15007, 10.1088/1748-6041/5/1/015007 · DOI
  42. Ochoa, 2013, A hybrid PDMS–parylene subdural multi-electrode array, Biomed Microdevices, 15, 437, 10.1007/s10544-013-9743-2 · DOI
  43. Pennisi, 2011, Nanoscale topography reduces fibroblast growth, focal adhesion size and migration-related gene expression on platinum surfaces, Colloids Surf B: Biointerfaces, 85, 189, 10.1016/j.colsurfb.2011.02.028 · DOI
  44. Pennisi, 2009, Responses of fibroblasts and glial cells to nanostructured platinum surfaces, Nanotechnology, 20, 385103, 10.1088/0957-4484/20/38/385103 · DOI
  45. Polikov, 2006, In vitro model of glial scarring around neuroelectrodes chronically implanted in the CNS, Biomaterials, 27, 5368, 10.1016/j.biomaterials.2006.06.018 · DOI
  46. Polikov, 2005, Response of brain tissue to chronically implanted neural electrodes, J Neurosci Methods, 148, 1, 10.1016/j.jneumeth.2005.08.015 · DOI · Paper page
  47. Rao, 2012, Neuroinflammation and synaptic loss, Neurochem Res, 37, 903, 10.1007/s11064-012-0708-2 · DOI
  48. Rao, 2012, Polyethylene glycol-containing polyurethane hydrogel coatings for improving the biocompatibility of neural electrodes, Acta Biomater, 8, 2233, 10.1016/j.actbio.2012.03.001 · DOI
  49. Rostworowski, 1997, Astrogliosis in the neonatal and adult murine brain post-trauma: elevation of inflammatory cytokines and the lack of requirement for endogenous interferon-gamma, J Neurosci, 17, 3664, 10.1523/JNEUROSCI.17-10-03664.1997 · DOI
  50. Samuel, 2003, Microfluidic devices fabricated in poly(dimethylsiloxane) for biological studies, Electrophoresis, 24, 3563, 10.1002/elps.200305584 · DOI
  51. Schmittgen, 2008, Analyzing real-time PCR data by the comparative C(T) method, Nat Protoc, 3, 1101, 10.1038/nprot.2008.73 · DOI · Paper page
  52. Seil, 2008, Decreased astroglial cell adhesion and proliferation on zinc oxide nanoparticle polyurethane composites, Int J Nanomed, 3, 523
  53. Shrikant, 1996, The central nervous system as an immunocompetent organ: role of glial cells in antigen presentation, J Immunol, 157, 1819, 10.4049/jimmunol.157.5.1819 · DOI
  54. Smeal, 2007, A rat brain slice preparation for characterizing both thalamostriatal and corticostriatal afferents, J Neurosci Methods, 159, 224, 10.1016/j.jneumeth.2006.07.007 · DOI
  55. Smith, 1997, Macrophage/microglia regulation of astrocytic tenascin: synergistic action of transforming growth factor-beta and basic fibroblast growth factor, J Neurosci, 17, 9624, 10.1523/JNEUROSCI.17-24-09624.1997 · DOI
  56. Sofroniew, 2010, Astrocytes: biology and pathology, Acta Neuropathol, 119, 7, 10.1007/s00401-009-0619-8 · DOI · Paper page
  57. Szarowski, 2003, Brain responses to micro-machined silicon devices, Brain Res, 983, 23, 10.1016/S0006-8993(03)03023-3 · DOI
  58. Merkel V.I.B, 2000, Gas sorption, diffusion, and permeation in poly(dimethylsiloxane), J Polym Sci B: Polym Phys, 38, 415, 10.1002/(SICI)1099-0488(20000201)38:3<415::AID-POLB8>3.0.CO;2-Z · DOI
  59. Taupin, 1993, Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion Influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand, J Neuroimmunol, 42, 177, 10.1016/0165-5728(93)90008-M · DOI
  60. Turner, 1999, Cerebral astrocyte response to micromachined silicon implants, Exp Neurol, 156, 33, 10.1006/exnr.1998.6983 · DOI
  61. Wu, 2006, Interfacing SH-SY5Y human neuroblastoma cells with SU-8 microstructures, Colloids Surf B: Biointerfaces, 52, 14, 10.1016/j.colsurfb.2006.06.001 · DOI
  62. Wyss-Coray, 2000, Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice, Am J Pathol, 156, 139, 10.1016/S0002-9440(10)64713-X · DOI
  63. Yim, 2007, Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage, Exp Cell Res, 313, 1820, 10.1016/j.yexcr.2007.02.031 · DOI · Paper page
  64. Yoles, 2001, Protective autoimmunity is a physiological response to CNS trauma, J Neurosci, 21, 3740, 10.1523/JNEUROSCI.21-11-03740.2001 · DOI
  65. Zervantonakis, 2011, Microfluidic devices for studying heterotypic cell–cell interactions and tissue specimen cultures under controlled microenvironments, Biomicrofluidics, 5, 13406, 10.1063/1.3553237 · DOI

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Metadata

Authors
Ereifej, E. S., Cheng, M. M.-C., Mao, G., & VandeVord, P. J.
Affiliations
Wayne State University (US)
Corresponding author
VandeVord, Pamela J.
ORCID
Venue
Journal of Neuroscience Methods
Publisher
Elsevier BV
Published
2013-07
Volume
217
Issue
1-2
Pages
17-25
ISSN
0165-0270 (ISSN-L)
DOI
10.1016/j.jneumeth.2013.04.023
OpenAlex
W2063861481
Cited by
19
References
1
Citations by year
2026: 1 · 2024: 2 · 2023: 1 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 2
FWCI
1.15
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Neuroscience Methods (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
nanopatterning, polydimethylsiloxane, glial scar, reactive astrogliosis, neuroinflammation, organotypic brain slice culture, nanotopography, glial fibrillary acidic protein, IL-1β, TNF-α, TGF-β1, cell alignment, chronic electrode implantation
MeSH terms
Animals, Animals, Newborn, Brain, Cells, Cultured, Dimethylpolysiloxanes, Electrodes, Implanted, Encephalitis, Equipment Design, Organ Culture Techniques, Cytokines, Rats, Sprague-Dawley, Equipment Failure Analysis, Rats, Nanoparticles, Molecular Imprinting

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