Tissue response to neural implants: the use of model systems toward new design solutions of implantable microelectrodes.

Gulino, Maurizio; Kim, Donghoon; Pané, Salvador; Santos, Sofia Duque; Pêgo, Ana Paula

doi:10.3389/fnins.2019.00689

Cited by 159Neuroscience and Neural EngineeringTissue Engineering and Regenerative MedicineUndergraduate Neuroscience Education and Research

Tissue response to neural implants: the use of model systems toward new design solutions of implantable microelectrodes.

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Gulino, Maurizio, Kim, Donghoon, Pané, Salvador, Santos, Sofia Duque, Pêgo, Ana Paula·2019·Frontiers in Neuroscience

DOI 10.3389/fnins.2019.00689PMC PMC6624471

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Abstract

The development of implantable neuroelectrodes is advancing rapidly as these tools are becoming increasingly ubiquitous in clinical practice, especially for the treatment of traumatic and neurodegenerative disorders. Electrodes have been exploited in a wide number of neural interface devices, such as deep brain stimulation, which is one of the most successful therapies with proven efficacy in the treatment of diseases like Parkinson or epilepsy. However, one of the main caveats related to the clinical application of electrodes is the nervous tissue response at the injury site, characterized by a cascade of inflammatory events, which culminate in chronic inflammation, and, in turn, result in the failure of the implant over extended periods of time. To overcome current limitations of the most widespread macroelectrode based systems, new design strategies and the development of innovative materials with superior biocompatibility characteristics are currently being investigated. This review describes the current state of the art of in vitro, ex vivo and in vivo models available for the study of neural tissue response to implantable microelectrodes. We particularly highlight new models with increased complexity that closely mimic in vivo scenarios and that can serve as promising alternatives to animal studies for investigation of microelectrodes in neural tissues. Additionally, we also express our view on the impact of the progress in the field of neural tissue engineering on neural implant research.

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Modification of the chemical composition of the surface of the electrodes by using different polymers and nanomaterials is a relatively simple way to control biological responses and improve long-term biotolerability of neural electrodes.
“Another relatively simple way to control the biological responses and improve the long-term biotolerability of neural electrodes is the modification of the chemical composition of the surface of the electrodes by using different polymers and nanomaterials (Hara et al., 2016; Fernandez and Botella, 2017; Gulino et al., 2019).”
From Toward Long-Term Communication With the Brain in the Blind by Intracortical Stimulation: Challenges and Future Prospects (2020) · cites this paper as Gulino et al., 2019

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Cell and Tissue Culture
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Soft Bioelectronics Based on Nanomaterials
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Recommendations for Responsible Development and Application of Neurotechnologies
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Hybrid graphene electrode for the diagnosis and treatment of epilepsy in free-moving animal models
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Electrophysiological Monitoring of Neurochemical-Based Neural Signal Transmission in a Human Brain–Spinal Cord Assembloid
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A Review on Electroactive Polymer–Metal Composites: Development and Applications for Tissue Regeneration
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A flexible strain-responsive sensor fabricated from a biocompatible electronic ink via an additive-manufacturing process
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Enhanced electrochemical performance of neural electrodes based on PEDOT : PSS hydrogel
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Transient neurovascular interface for minimally invasive neural recording and stimulation
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Tissue‐Engineered Cochlear Fibrosis Model Links Complex Impedance to Fibrosis Formation for Cochlear Implant Patients
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Potential of Photoelectric Stimulation with Ultrasmall Carbon Electrode on Neural Tissue: New Directions in Neurostimulation Technology Development
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Capturing Initial Understanding and Impressions of Surgical Therapy for Parkinson's Disease
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Inflammatory Foreign Body Response Induced by Neuro-Implants in Rat Cortices Depleted of Resident Microglia by a CSF1R Inhibitor and Its Implications
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Biocompatibility of Platinum Nanoparticles in Brain ex vivo Models in Physiological and Pathological Conditions
Gulino, M., Santos, S. D., & Pêgo, A. P. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.787518 · Cited by 22 · see citing works
Commonly Overlooked Factors in Biocompatibility Studies of Neural Implants
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Semiconductor Nanowire‐Based Cellular and Subcellular Interfaces
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TEGylated Double-Walled Carbon Nanotubes as Platforms to Engineer Neuronal Networks
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Multifunctional organic monolayer-based coatings for implantable biosensors and bioelectronic devices: Review and perspectives
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Authors: Gulino, M., Kim, D., Pané, S., Santos, S. D., & Pêgo, A. P.
Affiliations: Universidade do Porto (PT)
ETH Zurich (CH)
Corresponding author: Pêgo, Ana Paula
ORCID: Gulino, Maurizio
Kim, Donghoon
Pané, Salvador
Santos, Sofia Duque
Pêgo, Ana Paula
Venue: Frontiers in Neuroscience
Publisher: Frontiers Media SA
Published: 2019-07-05
Volume: 13
Pages: 689-689
ISSN: 1662-453X (ISSN-L)
DOI: 10.3389/fnins.2019.00689
PMC: PMC6624471
OpenAlex: W2949950011
Cited by: 159
References: 240
Citations by year: 2026: 18 · 2025: 25 · 2024: 23 · 2023: 31 · 2022: 22 · 2021: 29 · 2020: 10 · 2018: 1
FWCI: 2.00
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
ETH Zürich Research Collection (cc-by)
Funders: Fundação para a Ciência e a Tecnologia
European Research Council
Horizon 2020
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Life Sciences › Neuroscience › Cognitive Neuroscience › Undergraduate Neuroscience Education and Research
Keywords: neural implants, implantable microelectrodes, chronic inflammation, biocompatibility, in vitro model, ex vivo model, in vivo models, neural tissue engineering, deep brain stimulation, electrode design, traumatic brain injury, neurodegenerative diseases

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Tissue response to neural implants: the use of model systems toward new design solutions of implantable microelectrodes.

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