Cited by 152Multiple Sclerosis Research StudiesSystemic Lupus Erythematosus ResearchT-cell and B-cell Immunology

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains

Papenfuss, Tracey L., Rogers, Connie J., Gienapp, Ingrid, Yurrita, Maria, McClain, Melanie, Damico, Nicole, Valo, Janie, Song, Fei, Whitacre, Caroline C.·2004·Journal of Neuroimmunology

DOI 10.1016/j.jneuroim.2004.01.018

Open this paper in CoChat — free account

Abstract

Multiple sclerosis (MS) is more prevalent in women than men. We evaluated seven different mouse strains commonly used in the study of autoimmune diseases, for sex differences in the disease course of experimental autoimmune encephalomyelitis (EAE). Greater severity of EAE was observed in the female SJL immunized with two different peptides of myelin proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) as well as in the female ASW relative to males. Female NZW mice showed a greater incidence of EAE than males. However, male B10.PL and PL/J mice showed more severe disease than females. No sex differences were noted in the C57BL/6 or NOD strains.

Integrity signals

Registry

Crossref · 10.1016/j.jneuroim.2004.01.018

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Defining the clinical course of multiple sclerosis
LUBLIN, F. D., & Reingold, S. C. (1996) · Neurology · doi:10.1212/wnl.46.4.907 · Cited by 3,762
Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?
Wegmann, T. G., Lin, H., Guilbert, L., & Mosmann, T. R. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90235-d · Cited by 2,852
Sex differences in autoimmune disease
Whitacre, C. C. (2001) · Nature Immunology · doi:10.1038/ni0901-777 · Cited by 1,294
Self-citation
The T Lymphocyte In Experimental Allergic Encephalomyelitis
Zamvil, S. S., & Steinman, L. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.003051 · Cited by 1,013
Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System
Steinman, L. (1996) · Cell · doi:10.1016/s0092-8674(00)81107-1 · Cited by 892
A Gender Gap in Autoimmunity: Task Force on Gender, Multiple Sclerosis and Autoimmunity
Whitacre, C. C., Reingold, S. C., O'Looney, P. A., Blankenhorn, E., Brinley, F., Collier, E., Duquette, P., Fox, H., Giesser, B., Gilmore, W., et al. (1999) · Science · doi:10.1126/science.283.5406.1277 · Cited by 851
Self-citation
Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity
Goverman, J. M., Woods, A., Larson, L., Weiner, L. P., Hood, L., & Zaller, D. M. (1993) · Cell · doi:10.1016/0092-8674(93)90074-z · Cited by 684
Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis
Weiner, H. L., Mackin, G. A., Matsui, M., Orav, E. J., Khoury, S. J., Dawson, D. M., & Hafler, D. A. (1993) · Science · doi:10.1126/science.7680493 · Cited by 583
High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
Lafaille, J. J., Nagashima, K., Katsuki, M., & Tonegawa, S. (1994) · Cell · doi:10.1016/0092-8674(94)90419-7 · Cited by 532
Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences
Bjartmar, C., & Trapp, B. D. (2001) · Current Opinion in Neurology · doi:10.1097/00019052-200106000-00003 · Cited by 479
Testosterone Acts Directly on CD4+ T Lymphocytes to Increase IL-10 Production
Liva, S. M., & Voskuhl, R. R. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.2060 · Cited by 395
Low-Dose Estrogen Therapy Ameliorates Experimental Autoimmune Encephalomyelitis in Two Different Inbred Mouse Strains
Bebo, B. F., Fyfe-Johnson, A., Adlard, K., Beam, A. G., Vandenbark, A. A., & Offner, H. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.2080 · Cited by 341
Effect of estradiol on cytokine secretion by proteolipid protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects
Gilmore, W., Weiner, L. P., & Correale, J. D. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.1.446 · Cited by 317
Testosterone therapy ameliorates experimental autoimmune encephalomyelitis and induces a T helper 2 bias in the autoantigen-specific T lymphocyte response
Dalal, M. A., Kim, S., & Voskuhl, R. R. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.1.3 · Cited by 293
Estriol ameliorates autoimmune demyelinating disease: Implications for multiple sclerosis
Kim, S., Liva, S. M., Dalal, M. A., Verity, M. A., & Voskuhl, R. R. (1999) · Neurology · doi:10.1212/wnl.52.6.1230 · Cited by 268
Role of hormone-controlled Th1- and Th2-type cytokines in successful pregnancy
Piccinni, M. P. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00299-x · Cited by 257
Androgens Alter the Cytokine Profile and Reduce Encephalitogenicity of Myelin-Reactive T Cells
Bebo, B. F., Schuster, J. C., Vandenbark, A. A., & Offner, H. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.1.35 · Cited by 242
Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4.
Yoshimoto, T., Bendelac, A. S., Hu‐Li, J., & Paul, W. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11931 · Cited by 236
Sex steroids, glucocorticoids, stress and autoimmunity
Homo-Delarche, F., Fitzpatrick, F. T. A., Christeff, N., Nunez, E. A., Bach, J., & Dardenne, M. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90285-d · Cited by 235
Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination.
Raine, C. S., Cannella, B., Duijvestijn, A. M., & Cross, A. H. (1990) · PubMed · Cited by 229
Estrogen induces a potent suppression of experimental autoimmune encephalomyelities and collagen-induced arthritis in mice
Jansson, L., Olsson, T. P., & Holmdahl, R. (1994) · Journal of Neuroimmunology · doi:10.1016/0165-5728(94)90030-2 · Cited by 218
Progesterone as an immunomodulatory molecule
Szekeres‐Barthó, J., Barakonyi, A., Pár, G., Polgár, B., Palkovics, T., & Szereday, L. (2001) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00035-2 · Cited by 211
The Increased Susceptibility of Women to Multiple Sclerosis
Duquette, P., Pleines, J., Girard, M., Charest, L., Senécal‐Quevillon, M., & Masse, C. (1992) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100041664 · Cited by 173
Pertussis Toxin Modulates the Immune Response to Neuroantigens Injected in Incomplete Freund’s Adjuvant: Induction of Th1 Cells and Experimental Autoimmune Encephalomyelitis in the Presence of High Frequencies of Th2 Cells
Hofstetter, H. H., Shive, C. L., & Forsthuber, T. G. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.117 · Cited by 165
Gender differences in autoimmune demyelination in the mouse: Implications for multiple sclerosis
Voskuhl, R. R., Pitchekian‐Halabi, H., Mackenzie‐Graham, A., McFarland, H. F., & Raine, C. S. (1996) · Annals of Neurology · doi:10.1002/ana.410390608 · Cited by 143
Gonadal hormones influence the immune response to PLP 139–151 and the clinical course of relapsing experimental autoimmmune encephalomyelitis
Bebo, B. F., Zelinka-Vincent, E., Adamus, G., Amundson, D., Vandenbark, A. A., & Offner, H. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00214-2 · Cited by 130
17β‐estradiol inhibits cytokine, chemokine, and chemokine receptor mRNA expression in the central nervous system of female mice with experimental autoimmune encephalomyelitis
Matejuk, A., Adlard, K. L., Zamora, A., Silverman, M., Vandenbark, A. A., & Offner, H. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1183 · Cited by 128
Effect of anti-interferon-γ monoclonal antibody treatment on the development of experimental allergic encephalomyelitis in resistant mouse strains
Duong, T. T., Finkelman, F. D., Singh, B., & Strejan, G. H. (1994) · Journal of Neuroimmunology · doi:10.1016/0165-5728(94)90069-8 · Cited by 124
Oral Feeding with Ethinyl Estradiol Suppresses and Treats Experimental Autoimmune Encephalomyelitis in SJL Mice and Inhibits the Recruitment of Inflammatory Cells into the Central Nervous System
Subramanian, S., Matejuk, A., Zamora, A., Vandenbark, A. A., & Offner, H. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1548 · Cited by 117
SEX HORMONES AND SYSTEMIC LUPUS ERYTHEMATOSUS
Lahita, R. G. (2000) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70178-2 · Cited by 115
Type I Diabetes and Multiple Sclerosis Patients Target Islet Plus Central Nervous System Autoantigens; Nonimmunized Nonobese Diabetic Mice Can Develop Autoimmune Encephalitis
Winer, S., Astsaturov, I. A., Cheung, R. K., Gunaratnam, L., Kubiak, V., Cortez, M. A., Moscarello, M. A., O'Connor, P. W., McKerlie, C., BECKER, D. J., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2831 · Cited by 89
Studies on the Species-Variability of Experimental Allergic Encephalomyelitis in Guinea Pigs and Rats
Swanborg, R. H., Swierkosz, J. E., & Saieg, R. G. (1974) · The Journal of Immunology · doi:10.4049/jimmunol.112.2.594 · Cited by 88
Antibody Association with a Novel Model for Primary Progressive Multiple Sclerosis: Induction of Relapsing‐Remitting and Progressive Forms of EAE in H2S Mouse Strains
Tsunoda, I., Kuang, L., Theil, D. J., & Fujinami, R. S. (2000) · Brain Pathology · doi:10.1111/j.1750-3639.2000.tb00272.x · Cited by 86
Gender-Dependent IL-12 Secretion by APC Is Regulated by IL-10
Wilcoxen, S. C., Kirkman, E. L., Dowdell, K., & Stohlman, S. A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6237 · Cited by 84
Genetic Analysis of the Influence of Pertussis Toxin on Experimental Allergic Encephalomyelitis Susceptibility: An Environmental Agent Can Override Genetic Checkpoints
Blankenhorn, E. P., Butterfield, R. J., Rigby, R. J., Cort, L., Giambrone, D., McDermott, P., McEntee, K., Solowski, N. L., Meeker, N. D., Zachary, J. F., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.3420 · Cited by 77
Gender does not influence the susceptibility of C57BL/6 mice to develop chronic experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein
Okuda, Y., Okuda, M., & Bernard, C. C. A. (2002) · Immunology Letters · doi:10.1016/s0165-2478(01)00339-x · Cited by 77
Decreased IL-12 Production Underlies the Decreased Ability of Male Lymph Node Cells to Induce Experimental Autoimmune Encephalomyelitis
Kim, S., & Voskuhl, R. R. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.9.5561 · Cited by 75
Altered IL-4 mRNA Stability Correlates with Th1 and Th2 Bias and Susceptibility to Hypersensitivity Pneumonitis in Two Inbred Strains of Mice
Butler, N. S., Monick, M. M., Yarovinsky, T. O., Powers, L. S., & Hunninghake, G. W. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3700 · Cited by 74
Oligodendrocyte-specific gene expression in mouse brain: Use of a myelin-forming cell type-specific promoter in an adeno-associated virus
Chen, H., McCarty, D. M., Bruce, A. T., Suzuki, K., & Suzuki, K. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990215)55:4 · Cited by 71
Oestrogen induced suppression of collagen arthritis. IV: Progesterone alone does not affect the course of arthritis but enhances the oestrogen-mediated therapeutic effect
Jansson, L., & Holmdahl, R. (1989) · Journal of Reproductive Immunology · doi:10.1016/0165-0378(89)90033-8 · Cited by 64
Macrophages regulate induction of delayed‐type hypersensitivity and experimental allergic encephalomyelitis in SJL mice
Cua, D. J., Hinton, D. R., Kirkman, L., & Stohlman, S. A. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250830 · Cited by 63
Gender issues and multiple sclerosis
Voskuhl, R. R. (2002) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-002-0087-1 · Cited by 48
The pathogenicity of islet-infiltrating lymphocytes in the non-obese diabetic (NOD) mouse
Ablamunits, V. G., Elias, D., & Cohen, I. R. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.00802.x · Cited by 45
SJL and NOD macrophages are uniquely characterized by genetically programmed, elevated expression of the IL-12(p40) gene, suggesting a conserved pathway for the induction of organ-specific autoimmunity
Alleva, D. G., Johnson, E. B., Wilson, J., Beller, D. I., & Conlon, P. J. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.3.440 · Cited by 42
Sex difference in Lewis rats in the incidence of recurrent experimental allergic encephalomyelitis
Keith, A. B. (1978) · Nature · doi:10.1038/272824a0 · Cited by 34
The effect of gonadectomy on the clinical course of chronic experimental allergic encephalomyelitis
Trooster, W. J., Teelken, A. W., Gerrits, P. O., Lijnema, T. H., Loof, J. G., Minderhoud, J. M., & Nieuwenhuis, P. (1996) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(96)00027-3 · Cited by 24
Immunopathogenic and clinical relevance of antibodies against myelin oligodendrocyte glycoprotein (MOG) in Multiple Sclerosis
Berger, T., & Reindl, M. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6301-6_25 · Cited by 19
‘Lupus-Prone’ Mice Are Susceptible to Organ-Specific Autoimmune Disease, Experimental Allergic Encephalomyelitis
Zamvil, S. S., Al‐Sabbagh, A., Nelson, P. A., Kaul, D., Charles, M. S., Mitchell, D. J., Steinman, L., Weiner, H. L., & Kuchroo, V. K. (2008) · Pathobiology · doi:10.1159/000163887 · Cited by 5
Untitled work
(1996) · doi:10.1002/(sici)1097-4547(19960915)45:6
Untitled work
(1998) · doi:10.1002/(sici)1097-4547(19980515)52:4

Flagged first, then by citations

Sorted by citations

Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy
Muzio, L., Viotti, A., & Martino, G. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.742065 · Cited by 581
Active induction of experimental allergic encephalomyelitis
Stromnes, I. M., & Goverman, J. M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.285 · Cited by 572
A role for sex chromosome complement in the female bias in autoimmune disease
Smith-Bouvier, D. L., Divekar, A., Manda, S. V., Du, S., Tiwari-Woodruff, S. K., King, J. K., Arnold, A. P., Singh, R. R., & Voskuhl, R. R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20070850 · Cited by 398
Sex-related factors in multiple sclerosis susceptibility and progression
Voskuhl, R. R., & Gold, S. M. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.43 · Cited by 262
Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration
Spence, R. D., & Voskuhl, R. R. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.12.001 · Cited by 259

See all 152

Authors: Papenfuss, T. L., Rogers, C. J., Gienapp, I., Yurrita, M., McClain, M., Damico, N., Valo, J., Song, F., & Whitacre, C. C.
Affiliations: The Ohio State University (US)
Corresponding author: Papenfuss, Tracey L.
ORCID: Papenfuss, Tracey L.
Rogers, Connie J.
Damico, Nicole
Song, Fei
Venue: Journal of Neuroimmunology
Publisher: Elsevier BV
Published: 2004-05
Volume: 150
Issue: 1-2
Pages: 59-69
ISSN: 0165-5728 (ISSN-L)
DOI: 10.1016/j.jneuroim.2004.01.018
OpenAlex: W2048700200
Cited by: 152
References: 50
Citations by year: 2026: 5 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 9 · 2020: 7 · 2019: 14 · 2018: 8 · 2017: 8 · 2016: 11 · 2015: 11 · 2014: 7 · 2013: 4 · 2012: 4
FWCI: 3.82
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Neuroimmunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Multiple Sclerosis Society
National Institutes of Health
National Institute of Allergy and Infectious Diseases (R01AI043376, AI43376)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: experimental autoimmune encephalomyelitis, sex differences, multiple sclerosis, mouse strains, myelin proteolipid protein, myelin oligodendrocyte glycoprotein, SJL mice, NZW mice, disease severity, autoimmune disease susceptibility
MeSH terms: Amino Acid Sequence, Animals, Castration, Encephalomyelitis, Autoimmune, Experimental, Female, Male, Mice, Inbred C57BL, Mice, Inbred NZB, Mice, Inbred Strains, Molecular Sequence Data, Ovariectomy, Severity of Illness Index, Sex Characteristics, Species Specificity, Incidence, Mice, Inbred NOD, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks