The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains
Abstract
Multiple sclerosis (MS) is more prevalent in women than men. We evaluated seven different mouse strains commonly used in the study of autoimmune diseases, for sex differences in the disease course of experimental autoimmune encephalomyelitis (EAE). Greater severity of EAE was observed in the female SJL immunized with two different peptides of myelin proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) as well as in the female ASW relative to males. Female NZW mice showed a greater incidence of EAE than males. However, male B10.PL and PL/J mice showed more severe disease than females. No sex differences were noted in the C57BL/6 or NOD strains.
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In the citing paper
“A comprehensive comparison of EAE clinical disease scores in several mouse strains revealed that female SJL and ASW have more severe EAE than males when induced by active immunization (44).”
From SJL Mice Exposed to Cuprizone Intoxication Reveal Strain and Gender Pattern Differences in Demyelination (2009) · cites this paper as [44]
In the citing paper
“In the experimental autoimmune encephalomyelitis (EAE) animal model for demyelinating disease, several strains of rodents display gender differences in disease incidence and severity 3, 4, 44, 53.”
From SJL Mice Exposed to Cuprizone Intoxication Reveal Strain and Gender Pattern Differences in Demyelination (2009) · cites this paper as [44]
In the citing paper
“Nevertheless, these findings of gender differences are in contrast to those in the EAE model, in which female SJL mice are both more susceptible to disease induction and exhibit more severe neurological deficits 3, 44, 53.”
From SJL Mice Exposed to Cuprizone Intoxication Reveal Strain and Gender Pattern Differences in Demyelination (2009) · cites this paper as [44]
In the citing paper
“Interestingly, it has been shown that male and female mice present with similar disease courses, but that females often have increased infiltration of immune cells to the spinal cord accompanied by increased demyelination compared to males [152, 153].”
From Insights and challenges on animal models for progressive multiple sclerosis (2026) · cites this paper as [152]
In the citing paper
“The A.SW-EAE model offers a unique representation of both PPMS and SPMS, with disease courses that include both PMS phenotypes.”
From Insights and challenges on animal models for progressive multiple sclerosis (2026) · cites this paper as [152]
In the citing paper
“The model can be induced in both males and females, but females tend to present with increased severity compared to males [152].”
From Insights and challenges on animal models for progressive multiple sclerosis (2026) · cites this paper as [152]
Citations
Cites
Defining the clinical course of multiple sclerosis
LUBLIN, F. D., & Reingold, S. C. (1996) · Neurology · doi:10.1212/wnl.46.4.907 · Cited by 3,762
Wegmann, T. G., Lin, H., Guilbert, L., & Mosmann, T. R. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90235-d · Cited by 2,852
Sex differences in autoimmune disease
Whitacre, C. C. (2001) · Nature Immunology · doi:10.1038/ni0901-777 · Cited by 1,294
Self-citationThe T Lymphocyte In Experimental Allergic Encephalomyelitis
Zamvil, S. S., & Steinman, L. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.003051 · Cited by 1,013
Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System
Steinman, L. (1996) · Cell · doi:10.1016/s0092-8674(00)81107-1 · Cited by 892
A Gender Gap in Autoimmunity: Task Force on Gender, Multiple Sclerosis and Autoimmunity
Whitacre, C. C., Reingold, S. C., O'Looney, P. A., Blankenhorn, E., Brinley, F., Collier, E., Duquette, P., Fox, H., Giesser, B., Gilmore, W., et al. (1999) · Science · doi:10.1126/science.283.5406.1277 · Cited by 851
Self-citationGoverman, J. M., Woods, A., Larson, L., Weiner, L. P., Hood, L., & Zaller, D. M. (1993) · Cell · doi:10.1016/0092-8674(93)90074-z · Cited by 684
Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis
Weiner, H. L., Mackin, G. A., Matsui, M., Orav, E. J., Khoury, S. J., Dawson, D. M., & Hafler, D. A. (1993) · Science · doi:10.1126/science.7680493 · Cited by 583
Lafaille, J. J., Nagashima, K., Katsuki, M., & Tonegawa, S. (1994) · Cell · doi:10.1016/0092-8674(94)90419-7 · Cited by 532
Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences
Bjartmar, C., & Trapp, B. D. (2001) · Current Opinion in Neurology · doi:10.1097/00019052-200106000-00003 · Cited by 479
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Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy
Muzio, L., Viotti, A., & Martino, G. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.742065 · Cited by 581
Active induction of experimental allergic encephalomyelitis
Stromnes, I. M., & Goverman, J. M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.285 · Cited by 572
A role for sex chromosome complement in the female bias in autoimmune disease
Smith-Bouvier, D. L., Divekar, A., Manda, S. V., Du, S., Tiwari-Woodruff, S. K., King, J. K., Arnold, A. P., Singh, R. R., & Voskuhl, R. R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20070850 · Cited by 398
Sex-related factors in multiple sclerosis susceptibility and progression
Voskuhl, R. R., & Gold, S. M. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.43 · Cited by 262
Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration
Spence, R. D., & Voskuhl, R. R. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.12.001 · Cited by 259
Metadata
- Authors
- Papenfuss, T. L., Rogers, C. J., Gienapp, I., Yurrita, M., McClain, M., Damico, N., Valo, J., Song, F., & Whitacre, C. C.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Papenfuss, Tracey L.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 150
- Issue
- 1-2
- Pages
- 59-69
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2048700200
- Cited by
- 152
- References
- 50
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 9 · 2020: 7 · 2019: 14 · 2018: 8 · 2017: 8 · 2016: 11 · 2015: 11 · 2014: 7 · 2013: 4 · 2012: 4
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Multiple Sclerosis Society
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI043376, AI43376)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- experimental autoimmune encephalomyelitis, sex differences, multiple sclerosis, mouse strains, myelin proteolipid protein, myelin oligodendrocyte glycoprotein, SJL mice, NZW mice, disease severity, autoimmune disease susceptibility
- MeSH terms
- Amino Acid Sequence, Animals, Castration, Encephalomyelitis, Autoimmune, Experimental, Female, Male, Mice, Inbred C57BL, Mice, Inbred NZB, Mice, Inbred Strains, Molecular Sequence Data, Ovariectomy, Severity of Illness Index, Sex Characteristics, Species Specificity, Incidence, Mice, Inbred NOD, Mice
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