Cited by 152Multiple Sclerosis Research StudiesSystemic Lupus Erythematosus ResearchT-cell and B-cell Immunology

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Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains

Papenfuss, Tracey L., Rogers, Connie J., Gienapp, Ingrid, Yurrita, Maria, McClain, Melanie, Damico, Nicole, Valo, Janie, Song, Fei, Whitacre, Caroline C.·2004·Journal of Neuroimmunology

DOI 10.1016/j.jneuroim.2004.01.018

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Abstract

Multiple sclerosis (MS) is more prevalent in women than men. We evaluated seven different mouse strains commonly used in the study of autoimmune diseases, for sex differences in the disease course of experimental autoimmune encephalomyelitis (EAE). Greater severity of EAE was observed in the female SJL immunized with two different peptides of myelin proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) as well as in the female ASW relative to males. Female NZW mice showed a greater incidence of EAE than males. However, male B10.PL and PL/J mice showed more severe disease than females. No sex differences were noted in the C57BL/6 or NOD strains.

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Authors: Papenfuss, T. L., Rogers, C. J., Gienapp, I., Yurrita, M., McClain, M., Damico, N., Valo, J., Song, F., & Whitacre, C. C.
Affiliations: The Ohio State University (US)
Corresponding author: Papenfuss, Tracey L.
ORCID: Papenfuss, Tracey L.
Rogers, Connie J.
Damico, Nicole
Song, Fei
Venue: Journal of Neuroimmunology
Publisher: Elsevier BV
Published: 2004-05
Volume: 150
Issue: 1-2
Pages: 59-69
ISSN: 0165-5728 (ISSN-L)
DOI: 10.1016/j.jneuroim.2004.01.018
OpenAlex: W2048700200
Cited by: 152
References: 50
Citations by year: 2026: 5 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 9 · 2020: 7 · 2019: 14 · 2018: 8 · 2017: 8 · 2016: 11 · 2015: 11 · 2014: 7 · 2013: 4 · 2012: 4
FWCI: 3.82
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Neuroimmunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Multiple Sclerosis Society
National Institutes of Health
National Institute of Allergy and Infectious Diseases (R01AI043376, AI43376)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: experimental autoimmune encephalomyelitis, sex differences, multiple sclerosis, mouse strains, myelin proteolipid protein, myelin oligodendrocyte glycoprotein, SJL mice, NZW mice, disease severity, autoimmune disease susceptibility
MeSH terms: Amino Acid Sequence, Animals, Castration, Encephalomyelitis, Autoimmune, Experimental, Female, Male, Mice, Inbred C57BL, Mice, Inbred NZB, Mice, Inbred Strains, Molecular Sequence Data, Ovariectomy, Severity of Illness Index, Sex Characteristics, Species Specificity, Incidence, Mice, Inbred NOD, Mice

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Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains

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