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Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells
Abstract
Inflammatory cytokines, produced mainly by activated microglia in the brain, can enhance neuronal degeneration and the amyloid-beta-plaque production involved in Alzheimer's disease (AD). We previously demonstrated that the expression of the pro-inflammatory cytokine interleukin-18 (IL-18) colocalizes with plaques and hyperphoshorylated tau containing neurons in AD patients. Here we exposed neuron-like, differentiated SH-SY5Y neuroblastomas to IL-18 and observed that the protein levels of p35, Cdk5, GSK-3beta, and Ser15-phosphorylated p53 increased during 6 h-24 h. Tau phosphorylation and expression of cyclin G1, involved in neuronal regeneration, increased at 72 h. In vivo, over-expression of IL-18 may induce hyperphosphorylation of tau and induce cell cycle activators.
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“Another study also found that IL-18 may impact hyperphosphorylation of tau via cdk5/p35 and GSK-3β kinases [168].”
From Glial contributions to neurodegeneration in tauopathies (2017) · cites this paper as [168]
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Metadata
- Authors
- Ojala, J. O., Sutinen, E. M., Salminen, A., & Pirttilä, T.
- Affiliations
- University of Eastern Finland (FI)
- Corresponding author
- Ojala, Johanna O.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 205
- Issue
- 1-2
- Pages
- 86-93
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W1991780813
- Cited by
- 102
- References
- 71
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 7 · 2023: 12 · 2022: 4 · 2021: 7 · 2020: 13 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 9 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 2
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Keywords
- IL-18, tau phosphorylation, SH-SY5Y cells, Alzheimer's disease, inflammatory cytokines, microglia, cyclin-dependent kinase 5, GSK3β, p53 Ser15 phosphorylation, cyclin G1, tau hyperphosphorylation, neuroinflammation
- MeSH terms
- Humans, L-Lactate Dehydrogenase, Molecular Weight, Neuroblastoma, Phosphorylation, Phosphotransferases, Serine, Time Factors, Gene Expression, tau Proteins, Interleukin-18, Cell Line, Tumor
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