Cited by 102Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsAnesthesia and Neurotoxicity Research

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Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells

Ojala, Johanna O., Sutinen, Elina M., Salminen, Antero, Pirttilä, Tuula·2008·Journal of Neuroimmunology

DOI 10.1016/j.jneuroim.2008.09.012

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Abstract

Inflammatory cytokines, produced mainly by activated microglia in the brain, can enhance neuronal degeneration and the amyloid-beta-plaque production involved in Alzheimer's disease (AD). We previously demonstrated that the expression of the pro-inflammatory cytokine interleukin-18 (IL-18) colocalizes with plaques and hyperphoshorylated tau containing neurons in AD patients. Here we exposed neuron-like, differentiated SH-SY5Y neuroblastomas to IL-18 and observed that the protein levels of p35, Cdk5, GSK-3beta, and Ser15-phosphorylated p53 increased during 6 h-24 h. Tau phosphorylation and expression of cyclin G1, involved in neuronal regeneration, increased at 72 h. In vivo, over-expression of IL-18 may induce hyperphosphorylation of tau and induce cell cycle activators.

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Authors: Ojala, J. O., Sutinen, E. M., Salminen, A., & Pirttilä, T.
Affiliations: University of Eastern Finland (FI)
Corresponding author: Ojala, Johanna O.
ORCID: Ojala, Johanna O.
Salminen, Antero
Venue: Journal of Neuroimmunology
Publisher: Elsevier BV
Published: 2008-12
Volume: 205
Issue: 1-2
Pages: 86-93
ISSN: 0165-5728 (ISSN-L)
DOI: 10.1016/j.jneuroim.2008.09.012
OpenAlex: W1991780813
Cited by: 102
References: 71
Citations by year: 2026: 5 · 2025: 8 · 2024: 7 · 2023: 12 · 2022: 4 · 2021: 7 · 2020: 13 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 9 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 2
FWCI: 2.04
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Neuroimmunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
Keywords: IL-18, tau phosphorylation, SH-SY5Y cells, Alzheimer's disease, inflammatory cytokines, microglia, cyclin-dependent kinase 5, GSK3β, p53 Ser15 phosphorylation, cyclin G1, tau hyperphosphorylation, neuroinflammation
MeSH terms: Humans, L-Lactate Dehydrogenase, Molecular Weight, Neuroblastoma, Phosphorylation, Phosphotransferases, Serine, Time Factors, Gene Expression, tau Proteins, Interleukin-18, Cell Line, Tumor

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Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells

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