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Hyperphosphorylation of Tau in PHF

Morishima-Kawashima, Maho, Hasegawa, Masato, Takio, Koji, Suzuki, Masami, Yoshida, Hirotaka, Watanabe, Atsushi, Titani, Koiti, Ihara, Yasuo·1995·Neurobiology of Aging
DOI 10.1016/0197-4580(95)00027-c
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Abstract

Tau in PHF is known to be highly phosphorylated and immunochemical study has indicated the similarity of the phosphorylation between PHF-tau and fetal tau. We have determined the exact phosphorylation sites in both PHF-tau and fetal rat tau by ion-spray mass spectrometry and sequencing of ethanethiol-modified peptides. In PHF-tau, 19 sites have been identified; all the phosphorylation sites except for Ser-262 are localized to the amino- and carboxyl-terminal flanking regions of the microtubule-binding domain. Half of them are shared by fetal tau. Thus, PHF-tau is much more phosphorylated. Whereas most of the sites in fetal tau are proline-directed, half of them in PHF-tau are nonproline-directed. Overall, the hyperphosphorylation of PHF-tau can be considered to consist of fetal-type phosphorylation and additional proline-directed and nonproline-directed phosphorylation. This extraphosphorylation may provide PHF-tau with the unusual characteristics including assembly incompetence.

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  • Tau is a component of neurofibrillary tangles (NFT) in Alzheimer's disease and related tauopathies.

    “The microtubule-binding protein tau is a component of neurofibrillary tangles (NFT) in Alzheimer's disease (AD) and related disorders that are collectively referred to as tauopathies (Morishima-Kawashima et al. 1995), (Johnson and Bailey 2002).”

    From TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models (2026) · cites this paper as Morishima-Kawashima et al. 1995

  • Tau is a component of neurofibrillary tangles (NFT) in Alzheimer's disease (AD) and related tauopathies.

    “The microtubule-binding protein tau is a component of neurofibrillary tangles (NFT) in Alzheimer's disease (AD) and related disorders that are collectively referred to as tauopathies (Morishima-Kawashima et al. 1995), (Johnson and Bailey 2002).”

    From TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models (2026) · cites this paper as Morishima-Kawashima et al. 1995

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Metadata

Authors
Morishima-Kawashima, M., Hasegawa, M., Takio, K., Suzuki, M., Yoshida, H., Watanabe, A., Titani, K., & Ihara, Y.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
1995-05
Volume
16
Issue
3
Pages
365-371
ISSN
0197-4580
DOI
10.1016/0197-4580(95)00027-c
Cited by
202
References
5
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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