The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines

Neuropathic pain behaviours in a chronic-relapsing model of experimental autoimmune encephalomyelitis (EAE)

Olechowski, C. J., Truong, J. J., & Kerr, B. J. (2009) · Pain · doi:10.1016/j.pain.2008.11.002 · Cited by 159

Effect of NGF and anti-NGF on neuropathic pain in rats following chronic constriction injury of the sciatic nerve

Ro, L., Chen, S.-T., Tang, L., & Jacobs, J. M. (1999) · Pain · doi:10.1016/s0304-3959(98)00164-x · Cited by 158

Effects of interleukin-1 beta, interleukin-6, and tumor necrosis factor on sensitivity of dorsal root ganglion and peripheral receptive fields in rats

Özaktay, A. C., Kallakuri, S., Takebayashi, T., Cavanaugh, J. M., Aşık, İ., DeLeo, J. A., & Weinstein, J. N. (2006) · European Spine Journal · doi:10.1007/s00586-005-0058-8 · Cited by 158

Up-regulation of leukaemia inhibitory factor and interleukin-6 in transected sciatic nerve and muscle following denervation

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Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models

Xie, W., Strong, J. A., & Zhang, J.-M. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.03.016 · Cited by 157

HSV-Mediated Expression of Interleukin-4 in Dorsal Root Ganglion Neurons Reduces Neuropathic Pain

Hao, S., Mata, M. M., Glorioso, J. C., & Fink, D. J. (2006) · Molecular Pain · doi:10.1186/1744-8069-2-6 · Cited by 156

T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression

Kleinschnitz, C., Hofstetter, H. H., Meuth, S. G., Braeuninger, S., Sommer, C., & Stoll, G. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.03.014 · Cited by 154

TNF-alpha differentially modulates ion channels of nociceptive neurons.

Czeschik, J., Hagenacker, T., Schäfers, M., & Büsselberg, D. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.01.070 · Cited by 154

Caught in the Act:In VivoMapping of Macrophage Infiltration in Nerve Injury by Magnetic Resonance Imaging

Bendszus, M., & Stoll, G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10892.2003 · Cited by 152

Constitutive expression of CCR2 chemokine receptor and inhibition by MCP‐1/CCL2 of GABA‐induced currents in spinal cord neurones

Gosselin, R., Varela, C., Banisadr, G., Méchighel, P., Rostène, W. H., Kitabgi, P., & Parsadaniantz, S. M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03431.x · Cited by 152

Antinociceptive Effects of Interleukin-4, -10, and -13 on the Writhing Response in Mice and Zymosan-Induced Knee Joint Incapacitation in Rats

Vale, M. L., Marques, J. B., Moreira, C. A., Rocha, F. A. C., Ferreira, S. H., Poole, S., Cunha, F. Q., & Ribeiro, R. A. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.038703 · Cited by 152

Serial Determination of Tumor Necrosis Factor-Alpha Content in Rat Sciatic Nerve after Chronic Constriction Injury

George, A., Schmidt, C., Weishaupt, A., Toyka, K. V., & Sommer, C. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7193 · Cited by 151

Satellite glial cells in the trigeminal ganglion as a determinant of orofacial neuropathic pain

Vit, J., Jasmin, L., Bhargava, A., & Ohara, P. T. (2006) · Neuron Glia Biology · doi:10.1017/s1740925x07000427 · Cited by 151

CXCR4 chemokine receptor signaling mediates pain hypersensitivity in association with antiretroviral toxic neuropathy

Bhangoo, S. K., Ren, D., Miller, R. J., Chan, D., Ripsch, M. S., Weiß, C., McGinnis, C., & White, F. A. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.12.003 · Cited by 149

The purinergic antagonist PPADS reduces pain related behaviours and interleukin-1β, interleukin-6, iNOS and nNOS overproduction in central and peripheral nervous system after peripheral neuropathy in mice

Martucci, C., Trovato, A. E., Costa, B., Borsani, E., Franchi, S., Magnaghi, V., Panerai, A. E., Rodella, L. F., Valsecchi, A. E., Sacerdote, P., et al. (2007) · Pain · doi:10.1016/j.pain.2007.08.017 · Cited by 148

Interleukin-15 (IL-15) Induces IL-8 and Monocyte Chemotactic Protein 1 Production in Human Monocytes

Badolato, R., Ponzi, A. N., Millesimo, M., Notarangelo, L. D., & Musso, T. (1997) · Blood · doi:10.1182/blood.v90.7.2804 · Cited by 147

Involvement of spinal cord nuclear factor κB activation in rat models of proinflammatory cytokine‐mediated pain facilitation

Ledeboer, A., Gamanos, M., Lai, W., Martin, D., Maier, S. F., Watkins, L. R., & Quan, N. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04379.x · Cited by 147

Transforming Growth Factor-β1 Impairs Neuropathic Pain through Pleiotropic Effects

Echeverry, S., Shi, X., Haw, A., Liu, G., Zhang, Z., & Zhang, J. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-16 · Cited by 147

Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons

Obreja, O., Biasio, W., Andratsch, M., Lips, K. S., Rathee, P. K., Ludwig, A., Rose‐John, S., & Kress, M. (2005) · Brain · doi:10.1093/brain/awh490 · Cited by 146

Interleukin 6 in Intact and Injured Mouse Peripheral Nerves

Reichert, F., Levitzky, R., & Rotshenker, S. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01237.x · Cited by 143

Pain and purinergic signaling

Tsuda, M., Tozaki‐Saitoh, H., & Inoue, K. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.11.003 · Cited by 141

Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE2 release and thermal hyperalgesia

Svensson, C. I., Hua, X., Protter, A. A., Powell, H. C., & Yaksh, T. L. (2003) · Neuroreport · doi:10.1097/00001756-200306110-00010 · Cited by 141

Role of the cysteine protease cathepsin S in neuropathic hyperalgesia

Barclay, J., Clark, A. K., Ganju, P., Gentry, C., Patel, S., Wotherspoon, G., Buxton, F. P., Song, C., Ullah, J., Winter, J., et al. (2007) · Pain · doi:10.1016/j.pain.2006.11.017 · Cited by 140

Complement Depletion Reduces Macrophage Infiltration and Activation during Wallerian Degeneration and Axonal Regeneration

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Mode of action of cytokines on nociceptive neurons

Üçeyler, N., Schäfers, M., & Sommer, C. (2009) · Experimental Brain Research · doi:10.1007/s00221-009-1755-z · Cited by 139

Spinal nerve ligation induces transient upregulation of tumor necrosis factor receptors 1 and 2 in injured and adjacent uninjured dorsal root ganglia in the rat

Schäfers, M., Sorkin, L. S., Geis, C., & Shubayev, V. I. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00695-5 · Cited by 138

Antibacterial activity of human neutrophil defensins in experimental infections in mice is accompanied by increased leukocyte accumulation.

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Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury

Tawfik, V. L., Nutile‐McMenemy, N., LaCroix‐Fralish, M. L., & DeLeo, J. A. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.07.001 · Cited by 136

Anti-GD2 with an FC point mutation reduces complement fixation and decreases antibody-induced allodynia

Sorkin, L. S., Otto, M., Baldwin, W. M., Vail, E. A., Gillies, S. D., Handgretinger, R., Barfield, R. C., Yu, H. M., & Yu, A. L.-T. (2010) · Pain · doi:10.1016/j.pain.2010.01.024 · Cited by 136

Differential Regulation of Immune Responses and Macrophage/Neuron Interactions in the Dorsal Root Ganglion in Young and Adult Rats following Nerve Injury

Vega‐Avelaira, D., Géranton, S. M., & Fitzgerald, M. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-70 · Cited by 136

Interleukin-6 in combination with its soluble IL-6 receptor sensitises rat skin nociceptors to heat, in vivo

Obreja, O., Schmelz, M., Poole, S., & Kress, M. (2002) · Pain · doi:10.1016/s0304-3959(01)00420-1 · Cited by 135

Intrathecal interleukin-1β administration induces thermal hyperalgesia by activating inducible nitric oxide synthase expression in the rat spinal cord

Sung, C., Wen, Z., Chang, W., Ho, S., Tsai, S., Chang, Y., & Wong, C. (2004) · Brain Research · doi:10.1016/j.brainres.2004.04.068 · Cited by 134

Peripheral mechanisms of opioid antinociception in inflammation: involvement of cytokines

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Local expression of inducible nitric oxide synthase in an animal model of neuropathic pain

Levy, D., Höke, A., & Zochodne, D. W. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00982-3 · Cited by 134

Interferon-γ Is a Critical Modulator of CB2Cannabinoid Receptor Signaling during Neuropathic Pain

Rácz, I., Nadal, X., Alferink, J., Baños, J.-E., Rehnelt, J., Martín, M., Pintado, B., Gutiérrez‐Adán, A., Sanguino, E., Bellora, N., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3402-08.2008 · Cited by 134

Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC‐dependent site, serine‐896, in spinal cord dorsal horn neurons

Brenner, G. J., Ji, R., Shaffer, S., & Woolf, C. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03506.x · Cited by 132

Differential regulation of astrocyte TNF‐α expression by the cytokines TGF‐β, IL‐6 and IL‐10

Benveniste, E. N., Tang, L. P., & Law, R. M. (1995) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(94)00061-7 · Cited by 132

Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats

Twining, C. M., Sloane, E. M., Milligan, E. D., Chacur, M., Martin, D., Poole, S., Marsh, H. C., Maier, S. F., & Watkins, L. R. (2004) · Pain · doi:10.1016/j.pain.2004.04.008 · Cited by 131

Release of ATP from cultured rat astrocytes elicited by glutamate receptor activation

Queiróz, G., Gebicke‐Haerter, P. J., Schobert, A., Starke, K., & von Kügelgen, I. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00637-9 · Cited by 131

Spinal Glial Activation Contributes to Postoperative Mechanical Hypersensitivity in the Rat

Obata, H., Eisenach, J. C., Hussain, H., Bynum, T., & Vincler, M. A. (2006) · Journal of Pain · doi:10.1016/j.jpain.2006.04.004 · Cited by 131

A comparison of chronic pain behavior following local application of tumor necrosis factor α to the normal and mechanically compressed lumbar ganglia in the rat

Homma, Y., Brull, S. J., & Zhang, J. (2002) · Pain · doi:10.1016/s0304-3959(01)00404-3 · Cited by 129

Negative regulation of cytokine signaling influences inflammation

Yoshimura, A., Mori, H., Ohishi, M., Aki, D., & Hanada, T. (2003) · Current Opinion in Immunology · doi:10.1016/j.coi.2003.09.004 · Cited by 127

Control of inflammatory pain by chemokine-mediated recruitment of opioid-containing polymorphonuclear cells

Brack, A., Rittner, H. L., Machelska, H., Leder, K., Mousa, S. A., Schäfer, M., & Stein, C. (2004) · Pain · doi:10.1016/j.pain.2004.08.029 · Cited by 126

Regulation of cutaneous C-fiber heat nociceptors by nerve growth factor in the developing rat

Lewin, G. R., & Mendell, L. M. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.71.3.941 · Cited by 124

Autoantigen specific T cells inhibit glutamate uptake in astrocytes by decreasing expression of astrocytic glutamate transporter GLAST: a mechanism mediated by tumor necrosis factor‐α

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Glia in pathological pain: A role for fractalkine

Milligan, E. D., Sloane, E. M., & Watkins, L. R. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.04.011 · Cited by 123

Activation of JAK/STAT signalling in neurons following spinal cord injury in mice

Yamauchi, K., Osuka, K., Takayasu, M., Usuda, N., Nakazawa, A., Nakahara, N., Yoshida, M., Aoshima, C., Hara, M., & Yoshida, J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03559.x · Cited by 123

Involvement of Leukemia Inhibitory Factor in the Increases in Galanin and Vasoactive Intestinal Peptide mRNA and the Decreases in Neuropeptide Y and Tyrosine Hydroxylase mRNA in Sympathetic Neurons After Axotomy

Sun, Y. E., & Zigmond, R. E. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67041751.x · Cited by 121

Fibronectin/integrin system is involved in P2X4receptor upregulation in the spinal cord and neuropathic pain after nerve injury

Tsuda, M., Toyomitsu, E., Komatsu, T., Masuda, T., Kunifusa, E., Nasu‐Tada, K., Koizumi, S., Yamamoto, K., Ando, J., & Inoue, K. (2008) · Glia · doi:10.1002/glia.20641 · Cited by 121

Peripheral nerve injury induces endoneurial expression of IFN-γ, IL-10 and TNF-α mRNA

Taskinen, H., Olsson, T. P., Bucht, A., Khademi, M., Svelander, L., & Röyttä, M. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00154-x · Cited by 120

IL-15 Induces the Expression of Chemokines and Their Receptors in T Lymphocytes

Perera, L. P., Goldman, C. K., & Waldmann, T. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.5.2606 · Cited by 119

Pain in the Guillain-Barré syndrome: a clinical review

Pentland, B. T., & Donald, S. M. (1994) · Pain · doi:10.1016/0304-3959(94)90068-x · Cited by 119

Profiling of dynamically changed gene expression in dorsal root ganglia post peripheral nerve injury and a critical role of injury-induced glial fibrillary acetic protein in maintenance of pain behaviors

Kim, D.-S., Figueroa, K. W., Li, K.-W., Boroujerdi, A., Yolo, T., & Luo, D. Z. (2009) · Pain · doi:10.1016/j.pain.2009.02.006 · Cited by 119

Differential Implication of Proinflammatory Cytokine Interleukin-6 in the Development of Cephalic versus Extracephalic Neuropathic Pain in Rats

Latrémolière, A., Mauborgne, A., Masson, J., Bourgoin, S., Kayser, V., Hamon, M., & Pohl, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2552-08.2008 · Cited by 118

Association between Kinin B1 Receptor Expression and Leukocyte Trafficking across Mouse Mesenteric Postcapillary Venules

McLean, P. G., Ahluwalia, A., & Perretti, M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.367 · Cited by 118

Autoimmunity: increasing suspects in the CD4+ T cell lineup

Palmer, M. T., & Weaver, C. T. (2009) · Nature Immunology · doi:10.1038/ni.1802 · Cited by 117

MMPs initiate Schwann cell-mediated MBP degradation and mechanical nociception after nerve damage

Kobayashi, H., Chattopadhyay, S., Kato, K., Dolkas, J., Kikuchi, S., Myers, R. R., & Shubayev, V. I. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.08.008 · Cited by 116

Adrenergic innervation of rat sensory ganglia following proximal or distal painful sciatic neuropathy: distinct mechanisms revealed by anti‐NGF treatment

Ramer, M. S., & Bisby, M. A. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00491.x · Cited by 116

Roles of P2 receptors in glial cells: focus on astrocytes

Abbracchio, M. P., & Ceruti, S. (2006) · Purinergic Signalling · doi:10.1007/s11302-006-9016-0 · Cited by 116

Early cytokine expression in mouse sciatic nerve after chronic constriction nerve injury depends on calpain

Üçeyler, N., Tscharke, A., & Sommer, C. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.10.003 · Cited by 116

1-(2′,4′-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice

Luongo, L., Palazzo, E., Tambaro, S., Giordano, C. S. D. S., Gatta, L., Scafuro, M. A., Rossi, F., Lazzari, P., Pani, L., de Novellis, V., et al. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.09.021 · Cited by 116

Acute Topical Application of Tumor Necrosis Factor α Evokes Protein Kinase A-Dependent Responses in Rat Sensory Neurons

Zhang, J., Li, H., Liu, B., & Brull, S. J. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.3.1387 · Cited by 115

The contributing role of CD14 in toll-like receptor 4 dependent neuropathic pain

Cao, L., Tanga, F. Y., & DeLeo, J. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.004 · Cited by 114

Reciprocal actions of interleukin‐6 and brain‐derived neurotrophic factor on rat and mouse primary sensory neurons

Murphy, P. G., Borthwick, L. A., Altares, M., Gauldie, J., Kaplan, D. R., & Richardson, P. M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00074.x · Cited by 114

Bilateral changes of TNF-α and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve

Jančálek, R., Dubový, P., Svíženská, I. H., & Klusáková, I. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-11 · Cited by 114

Peri-sciatic administration of recombinant rat TNF-α induces mechanical allodynia via upregulation of TNF-α in dorsal root ganglia and in spinal dorsal horn: The role of NF-kappa B pathway

Wei, X., Zang, Y., Wu, C. Y., Xu, J., Xin, W., & Liu, X. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.03.012 · Cited by 112

Antibodies to Nerve Growth Factor Reverse Established Tactile Allodynia in Rodent Models of Neuropathic Pain without Tolerance

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Constitutive Spinal Cyclooxygenase-2 Participates in the Initiation of Tissue Injury-Induced Hyperalgesia

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Clinical efficacy of antihistaminics as analgesics

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The role of nucleotides in the neuron–glia communication responsible for the brain functions

Inoue, K., Koizumi, S., & Tsuda, M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04824.x · Cited by 105

Enduring Reversal of Neuropathic Pain by a Single Intrathecal Injection of Adenosine 2A Receptor Agonists: A Novel Therapy for Neuropathic Pain

Loram, L. C., Harrison, J. A., Sloane, E. M., Hutchinson, M. R., Sholar, P. W., Taylor, F. R., Berkelhammer, D. L., Coats, B. D., Poole, S., Milligan, E. D., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3447-09.2009 · Cited by 105

Interleukin 1β Modulates Rat Subfornical Organ Neurons as a Result of Activation of a Non‐Selective Cationic Conductance

Desson, S. E., & Ferguson, A. V. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.041210 · Cited by 102

Immune Responsiveness in the Neonatal Period

Morein, B., Blomqvist, G., & Hu, K. (2007) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2007.04.008 · Cited by 101

Erythropoietin reduces Schwann cell TNF‐α, Wallerian degeneration and pain‐related behaviors after peripheral nerve injury

Campana, W. M., Li, X., Shubayev, V. I., Angert, M., Cai, K., & Myers, R. R. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04606.x · Cited by 101

Transient early expression of TNF-α in sciatic nerve and dorsal root ganglia in a mouse model of painful peripheral neuropathy

Sacerdote, P., Franchi, S., Trovato, A. E., Valsecchi, A. E., Panerai, A. E., & Colleoni, M. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.03.023 · Cited by 99

Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury

Ma, W., & Eisenach, J. C. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00495-0 · Cited by 98

Characteristics of histamine-induced leukocyte rolling in the undisturbed microcirculation of the rat mesentery

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Selective local PMN recruitment by CXCL1 or CXCL2/3 injection does not cause inflammatory pain

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Intra- and Extraneuronal Changes of Immunofluorescence Staining for TNF- and TNFR1 in the Dorsal Root Ganglia of Rat Peripheral Neuropathic Pain Models

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Tocilizumab for rheumatoid arthritis

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Selective Reactions of Cutaneous and Muscle Afferent Neurons to Peripheral Nerve Transection in Rats

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Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats

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HSV-mediated transfer of interleukin-10 reduces inflammatory pain through modulation of membrane tumor necrosis factor α in spinal cord microglia

Zhou, Z., Peng, X., Hao, S., Fink, D. J., & Mata, M. M. (2007) · Gene Therapy · doi:10.1038/sj.gt.3303054 · Cited by 94

Interleukin‐6 induces microglial CX3CR1 expression in the spinal cord after peripheral nerve injury through the activation of p38 MAPK

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Increased Chemokine Signaling in a Model of HIV1-Associated Peripheral Neuropathy

Bhangoo, S. K., Ripsch, M. S., Buchanan, D. J., Miller, R. J., & White, F. A. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-48 · Cited by 94

Hyperalgesia in an animal model of multiple sclerosis

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Interleukin-1β enhances NMDA receptor-mediated current but inhibits excitatory synaptic transmission

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Chemical mediators enhance the excitability of unmyelinated sensory axons in normal and injured peripheral nerve of the rat

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The extent of cytokine induction in peripheral nerve lesions depends on the mode of injury and NMDA receptor signaling

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