Cited by 608Pain Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration MechanismsPain Management and Treatment

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The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines

Austin, Paul J., Moalem-Taylor, Gila·2010·Journal of Neuroimmunology

DOI 10.1016/j.jneuroim.2010.08.013

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Abstract

In a large proportion of individuals nervous system damage may lead to a debilitating chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder, since recent data indicate a critical involvement of innate and adaptive immune responses following nerve injury. Activation of immune and immune-like glial cells in the injured nerve, dorsal root ganglia and spinal cord results in the release of both pro- and anti-inflammatory cytokines, as well as algesic and analgesic mediators, the balance of which determines whether pain chronicity is established. This review will critically examine the role of the immune system in modulating chronic pain in animal models of nervous system injury, and highlight the possible therapeutic opportunities to intervene in the development and maintenance of neuropathic pain.

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Self-citation
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“…microglia and contribute to pain hypersensitivity inmodels of neuropathy; the ionotropic receptors, P2X4 (Coull et al., 2005; Tsuda et al., 2003, 2008) and P2X7 (Chessell et al., 2005; Clark et al., 2010); as well as the metabotropic, P2Y12 (Kobayashi et al., 2008b; Tozaki-Saitoh et al., 2008).”
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Monocyte chemoattractant protein‐1 functions as a neuromodulator in dorsal root ganglia neurons
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Tyrosine Phosphorylation of the NR2B Subunit of the NMDA Receptor in the Spinal Cord during the Development and Maintenance of Inflammatory Hyperalgesia
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Complement Induction in Spinal Cord Microglia Results in Anaphylatoxin C5a-Mediated Pain Hypersensitivity
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Interleukin-17 Contributes to Neuroinflammation and Neuropathic Pain Following Peripheral Nerve Injury in Mice
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The Liberation of Fractalkine in the Dorsal Horn Requires Microglial Cathepsin S
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Pro- and Anti-inflammatory Cytokine Gene Expression in Rat Sciatic Nerve Chronic Constriction Injury Model of Neuropathic Pain
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Long‐term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin‐1 receptor antagonist) in patients with rheumatoid arthritis: Extension phase of a randomized, double‐blind, placebo‐controlled trial
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Silencing the Kir4.1 Potassium Channel Subunit in Satellite Glial Cells of the Rat Trigeminal Ganglion Results in Pain-Like Behavior in the Absence of Nerve Injury
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Leukemia Inhibitory Factor Determines the Growth Status of Injured Adult Sensory Neurons
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Authors: Austin, P. J., & Moalem-Taylor, G.
Affiliations: UNSW Sydney (AU)
Corresponding author: Austin, Paul J.
ORCID: Austin, Paul J.
Venue: Journal of Neuroimmunology
Publisher: Elsevier BV
Published: 2010-12
Volume: 229
Issue: 1-2
Pages: 26-50
ISSN: 0165-5728 (ISSN-L)
DOI: 10.1016/j.jneuroim.2010.08.013
OpenAlex: W2111964682
Semantic Scholar: 1eb0fd50688ee519889d6649f4b3dbab6c461a2a
Cited by: 607
References: 401
Citations by year: 2026: 28 · 2025: 28 · 2024: 26 · 2023: 49 · 2022: 26 · 2021: 46 · 2020: 40 · 2019: 41 · 2018: 38 · 2017: 42 · 2016: 52 · 2015: 47 · 2014: 39 · 2013: 43 · 2012: 31
FWCI: 3.41
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Neuroimmunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: neuropathic pain, neuroimmune interactions, chronic pain, cytokines, dorsal root ganglia, spinal cord, nerve injury, pain chronicity
MeSH terms: Animals, Humans, Immune System, Inflammation, Nervous System, Neuralgia, Neuroglia, Cytokines

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The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines

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