The DOI matches its Crossref record; 399 of the 401 references it cites were found in a registry or an index.
The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines
Abstract
In a large proportion of individuals nervous system damage may lead to a debilitating chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder, since recent data indicate a critical involvement of innate and adaptive immune responses following nerve injury. Activation of immune and immune-like glial cells in the injured nerve, dorsal root ganglia and spinal cord results in the release of both pro- and anti-inflammatory cytokines, as well as algesic and analgesic mediators, the balance of which determines whether pain chronicity is established. This review will critically examine the role of the immune system in modulating chronic pain in animal models of nervous system injury, and highlight the possible therapeutic opportunities to intervene in the development and maintenance of neuropathic pain.
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In the citing paper
“Neuropathic pain pathophysiology is complex and includes functional alterations of the CNS and PNS (Cohen and Mao, 2014) in addition to neuro-immune interactions (Austin and Moalem-Taylor, 2010).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Austin and Moalem-Taylor, 2010
In the citing paper
“Five nights of partial sleep deprivation led to a reduction of stimulated IL-2 production in healthy humans (24), which is in line with the studies manipulating sleep for only one night.”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [24]
In the citing paper
“In addition, sleep, by favoring pro-inflammatory and Th1 cytokine production, further supports the interaction between APCs and T cells and the subsequent differentiation and proliferation of Th1 cells, eventually leading to the formation of IgG1 and IgG3 antibodies (24, 67, 148, 254, 320).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [24]
In the citing paper
“Such a shift in the Th1/Th2 balance has been also observed for alcohol dependence-associated sleep changes (462) and in response to experimental sleep deficiency (24, 320), and may explain lower vaccine efficacy and increased infection risk in the context of sleep deficiency”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [24]
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Cites
1 retracted
Obata, K., Katsura, H., Miyoshi, K., Kondo, T., Yamanaka, H., Kobayashi, K., Dai, Y., Fukuoka, T., Akira, S., & Noguchi, K. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05353.x · Cited by 80
RetractedTakeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376
Central sensitization: a generator of pain hypersensitivity by central neural plasticity
Latremoliere, A., & Woolf, C. J. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.06.012 · Cited by 3,913
Neuronal plasticity: Increasing the gain in pain
Woolf, C. J., & Salter, M. W. (2000) · Science · doi:10.1126/science.288.5472.1765 · Cited by 3,781 · cited 1×
“It is not the aim of this article to review the mechanisms of neuropathic pain, and we encourage the reader to see the many excellent reviews on the subject (Costigan et al., 2009b; Latremoliere and Woolf, 2009; Woolf, 2004; Woolf and Salter, 2000).”
The expanding universe of T-cell subsets: Th1, Th2 and more
Mosmann, T. R., & Sad, S. (1996) · Immunology Today · doi:10.1016/0167-5699(96)80606-2 · Cited by 3,603
Ho Kim, S., & Mo Chung, J. (1992) · Pain · doi:10.1016/0304-3959(92)90041-9 · Cited by 3,069
Neutrophils and immunity: challenges and opportunities
Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971
Walport, M. J. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104053441406 · Cited by 2,969
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
Cited by
Sorted by citations
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479
“, HIV, RA), numerous other diseases emerged in the last decades for which mild systemic elevations of inflammatory markers are characteristic, including cardiovascular (481) and metabolic diseases (153), certain forms of chronic pain (23), certain cancers (165), and neurodegenerative diseases (9).”
BackgroundPathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy
Sloan, G., Selvarajah, D., & Tesfaye, S. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00496-z · Cited by 534
Importance of glial activation in neuropathic pain
Mika, J., Żychowska, M., Popiołek-Barczyk, K., Rojewska, E., & Przewłocka, B. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.01.072 · Cited by 463
Richebé, P., Capdevila, X., & Rivat, C. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002238 · Cited by 448
Hutchinson, M. R., Shavit, Y., Grace, P. M., Rice, K. C., Maier, S. F., & Watkins, L. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.004135 · Cited by 397
Metadata
- Authors
- Austin, P. J., & Moalem-Taylor, G.
- Affiliations
- UNSW Sydney (AU)
- Corresponding author
- Austin, Paul J.
- ORCID
- Austin, Paul J.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 229
- Issue
- 1-2
- Pages
- 26-50
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2111964682
- Semantic Scholar
- 1eb0fd50688ee519889d6649f4b3dbab6c461a2a
- Cited by
- 607
- References
- 401
- Citations by year
- 2026: 28 · 2025: 28 · 2024: 26 · 2023: 49 · 2022: 26 · 2021: 46 · 2020: 40 · 2019: 41 · 2018: 38 · 2017: 42 · 2016: 52 · 2015: 47 · 2014: 39 · 2013: 43 · 2012: 31
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- neuropathic pain, neuroimmune interactions, chronic pain, cytokines, dorsal root ganglia, spinal cord, nerve injury, pain chronicity
- MeSH terms
- Animals, Humans, Immune System, Inflammation, Nervous System, Neuralgia, Neuroglia, Cytokines
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