Dynamic Regulation of Proinflammatory Cytokines
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Cortisol secreted from the adrenal cortex as a result of HPA-axis activation is most important in peripheral cytokine production; low cortisol increases proinflammatory cytokine production, while high cortisol inhibits it.
“Cortisol secreted from the adrenal cortex as a result of HPA-axis activation is most important in peripheral cytokine production. When cortisol levels are low, the production of proinflammatory cytokines increases, while their production is inhibited when cortisol levels are high[6].”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [6]
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Cytokines and major depression
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- Authors
- Watkins, L. R., Nguyen, K. T., Lee, J. E., & Maier, S. F.
- Affiliations
- University of Colorado Boulder (US)
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer US
- Published
- 1999
- Volume
- 461
- Pages
- 153-178
- ISSN
- 0065-2598 (ISSN-L)
- 2214-8019
- OpenAlex
- W185068922
- Cited by
- 67
- References
- 204
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 2.74
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- inflammatory cytokines, IL-1β, interleukin-6, TNF-α, sickness behavior, fever, neuroinflammation, cytokine regulation
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Inflammation, Interleukin-1, Stress, Physiological, Tumor Necrosis Factor-alpha, Interleukin-6, Cytokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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