Decreased levels of total immunoglobulin in children with autism are not a result of B cell dysfunction
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Autism spectrum disorders are a heterogeneous group of behaviorally defined disorders having complex etiologies. We previously reported a direct correlation between lower plasma levels of the immunoglobulins (Ig) IgG and IgM and increased severity of behavioral symptoms in children with autism. Our current objective was to determine if these reduced plasma levels of IgG and IgM are the result of defective B cell development, activation, or function. Results suggest no differences in the B cell parameters measured, indicating that decreased Ig in autism is not a result of B cell dysfunction and other immune cells might be involved.
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A 2012 follow-up study ruled out abnormal B-cell function as the source of aberrant IgG levels.
“A 2012 follow-up study ruled out abnormal B-cell function as the source of aberrant IgG levels (Heuer et al, 2012).”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Heuer et al, 2012
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The Role of the Immune System in Autism Spectrum Disorder
Meltzer, A., & Van de Water, J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.158 · Cited by 533 · see citing works
Immune Dysregulation in Autism Spectrum Disorder: What Do We Know about It?
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- Authors
- Heuer, L. S., Rose, M., Ashwood, P., & Van de Water, J.
- Affiliations
- University of California, Davis (US)
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 251
- Issue
- 1-2
- Pages
- 94-102
- ISSN
- 0165-5728 (ISSN-L)
- PMC
- PMC3432686
- OpenAlex
- W2057746952
- Cited by
- 28
- References
- 40
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 1 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 2
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Environmental Health Sciences (1 P01 ES11269-01, R01ES015359, P01ES011269)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, IgG, immunoglobulin M, B cell dysfunction, B cell development, B cell activation
- MeSH terms
- Autistic Disorder, B-Lymphocytes, Child, Child, Preschool, Female, Humans, Immunoglobulins, Lymphocyte Activation, Male, Severity of Illness Index
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