The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease
Abstract
Oxidative stress is suggested to play an important role in the pathogenesis of Parkinson's disease (PD). However, no elevation of plasma oxidative stress marker has been reported. We measured percent content of the oxidized form of coenzyme Q10 in total coenzyme Q10 (%CoQ-10) because %CoQ-10 has been shown to be a sensitive marker of oxidative stress. A slight but significant elevation in %CoQ-10 was observed in PD patients when compared with age/gender-matched normal subjects, suggesting elevated systemic oxidative stress in PD patients.
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“Significantly decreased levels of CoQ10 have been detected in the cortex of post-mortem brain tissues of Parkinson’s brains. In addition, the level of the oxidized form of ubiquinone has been found to be increased compared to healthy subjects (Sohmiya et al. 2004).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Sohmiya et al. 2004
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases
Tan, B. L., Norhaizan, M. E., Liew, W.-P.-P., & Rahman, H. S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01162 · Cited by 1,221
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Golomb, B. A., & Evans, M. A. (2008) · American Journal of Cardiovascular Drugs · doi:10.2165/0129784-200808060-00004 · Cited by 677
Duan, Y., Gong, K., Xu, S., Zhang, F., Meng, X., & Han, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01125-5 · Cited by 538
Oxidative Stress in Parkinson's Disease
Zhou, C. H., Huang, Y., & Przedborski, S. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.023 · Cited by 460
Metadata
- Authors
- Sohmiya, M., Tanaka, M., Wei Tak, N., Yanagisawa, M., Tanino, Y., Suzuki, Y., Okamoto, K., & Yamamoto, Y.
- Affiliations
- Gunma University (JP)
- The University of Tokyo (JP)
- Tokyo University of Technology (JP)
- Corresponding author
- Sohmiya, Makoto
- ORCID
- Okamoto, Koichi
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 223
- Issue
- 2
- Pages
- 161-166
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2117733672
- Cited by
- 143
- References
- 52
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 10 · 2022: 5 · 2021: 7 · 2020: 14 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 4 · 2013: 8 · 2012: 6
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- Parkinson's disease, oxidative stress, coenzyme Q10, plasma biomarkers, redox state, neurodegeneration
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Chromatography, High Pressure Liquid, Coenzymes, Electrochemistry, Female, Humans, Male, Middle Aged, Oxidation-Reduction, Parkinson Disease, Plasma, Ubiquinone, Case-Control Studies, Oxidative Stress, Statistics, Nonparametric
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